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- W3087171576 abstract "In this work, the solubility of rutin was first obtained in the water-ethanol solvents with small composition of co-solvent in the mixture at 25 °C. The results showed that the solubility of rutin improved with increasing ethanol content in the studied range 0–0.1 mol. fr. Solvation of hydroxypropyl-β-cyclodextrin in binary solvents was first studied by the method of interfacial distribution of the substance between two immiscible phases. It was found that when moving hydroxypropyl-β-cyclodextrin from water to the water-ethanol solvent, a decrease in the solvation of hydroxypropyl-β-cyclodextrin was observed. Complexation between rutin and β-cyclodextrin or hydroxypropyl-β-cyclodextrin was also studied in water and in the water-ethanol solvents. In the aqueous solution containing hydroxypropyl-β-cyclodextrin, the solubility of rutin was improved significantly and better than in the solution containing β-cyclodextrin. The stability of (rutin-hydroxypropyl-β-cyclodextrin) complex decreased with increasing the ethanol content and was determined by the sum of solvation of rutin (ΔtrGRuT) and hydroxypropyl-β-cyclodextrin (ΔtrGHPβCD). This effect was also observed for the complexation reaction between quercetin and hydroxypropyl-β-cyclodextrin in our previous study." @default.
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- W3087171576 date "2020-11-01" @default.
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- W3087171576 title "Effect of cyclodextrin types and reagents solvation on the stability of complexes between B-cyclodextrins and rutin in water-ethanol solvents" @default.
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- W3087171576 doi "https://doi.org/10.1016/j.molliq.2020.114308" @default.
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