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- W3087177675 endingPage "1476" @default.
- W3087177675 startingPage "1457" @default.
- W3087177675 abstract "Immunotherapies are revolutionizing the clinical management of a wide range of cancers. However, intrinsic or acquired unresponsiveness to immunotherapies does occur due to the dynamic cancer immunoediting which ultimately leads to immune escape. The evolutionarily conserved histone modifier enhancer of zeste 2 (EZH2) is aberrantly overexpressed in a number of human cancers. Accumulating studies indicate that EZH2 is a main driver of cancer cells’ immunoediting and mediate immune escape through downregulating immune recognition and activation, upregulating immune checkpoints and creating an immunosuppressive tumor microenvironment. In this review, we overviewed the roles of EZH2 in cancer immunoediting, the preclinical and clinical studies of current pharmacologic EZH2 inhibitors and the prospects for EZH2 inhibitor and immunotherapy combination for cancer treatment." @default.
- W3087177675 created "2020-09-25" @default.
- W3087177675 creator A5007291713 @default.
- W3087177675 creator A5029919899 @default.
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- W3087177675 creator A5037988586 @default.
- W3087177675 creator A5075365608 @default.
- W3087177675 creator A5079850601 @default.
- W3087177675 date "2020-08-01" @default.
- W3087177675 modified "2023-10-15" @default.
- W3087177675 title "EZH2 inhibition: a promising strategy to prevent cancer immune editing" @default.
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