Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087180599> ?p ?o ?g. }
- W3087180599 abstract "The expected increase in prevalence of Parkinson´s disease (PD) as the most common neurodegenerative movement disorder over the next years underscores the need for a better understanding of the underlying molecular pathogenesis. Here, genetics provided first insights over the last two decades, and dysfunction of molecular and organellar quality control has been described. Mechanisms involved relate to impaired intracellular calcium homeostasis and mitochondrial dynamics, which are tightly linked to the crosstalk between the endoplasmic reticulum (ER) and mitochondria. A number of proteins related to monogenic forms of PD have been mapped to these pathways, i.e. PINK1, Parkin, LRRK2 and α-synuclein. Recently, Miro1 was identified as an important player, as several studies linked Miro1 to mitochondrial quality control by PINK1/Parkin-mediated mitophagy and mitochondrial transport. Moreover, Miro1 is an important regulator of mitochondria-ER contact sites (MERCs), where it acts as a sensor for cytosolic calcium levels. The involvement of Miro1 in the pathogenesis of PD was recently confirmed by genetic evidence based on the first PD patients with heterozygous mutations in RHOT1/Miro1. Patient-based cellular models from RHOT1/Miro1 mutation carriers showed impaired calcium homeostasis, structural alterations of MERCs and increased mitochondrial clearance. To account for the emerging role of Miro1, we present a comprehensive overview focusing on the role of this protein in PD-related neurodegeneration and highlighting new developments in our understanding of Miro1, which provides new avenues for neuroprotective therapies for PD patients." @default.
- W3087180599 created "2020-09-25" @default.
- W3087180599 creator A5035939877 @default.
- W3087180599 creator A5048161396 @default.
- W3087180599 creator A5061417948 @default.
- W3087180599 creator A5064604387 @default.
- W3087180599 creator A5072348026 @default.
- W3087180599 date "2020-09-15" @default.
- W3087180599 modified "2023-09-25" @default.
- W3087180599 title "The Emerging Role of RHOT1/Miro1 in the Pathogenesis of Parkinson's Disease" @default.
- W3087180599 cites W1495825745 @default.
- W3087180599 cites W1506615318 @default.
- W3087180599 cites W1564026327 @default.
- W3087180599 cites W1927447627 @default.
- W3087180599 cites W1935060748 @default.
- W3087180599 cites W1964036976 @default.
- W3087180599 cites W1965513315 @default.
- W3087180599 cites W1966201817 @default.
- W3087180599 cites W1969971056 @default.
- W3087180599 cites W1970302092 @default.
- W3087180599 cites W1970979133 @default.
- W3087180599 cites W1974214519 @default.
- W3087180599 cites W1974434733 @default.
- W3087180599 cites W1977966828 @default.
- W3087180599 cites W1981592463 @default.
- W3087180599 cites W1983861120 @default.
- W3087180599 cites W1987804473 @default.
- W3087180599 cites W1993398538 @default.
- W3087180599 cites W1993696187 @default.
- W3087180599 cites W1996764498 @default.
- W3087180599 cites W1997527771 @default.
- W3087180599 cites W1997563565 @default.
- W3087180599 cites W1998654006 @default.
- W3087180599 cites W2001410029 @default.
- W3087180599 cites W2010572143 @default.
- W3087180599 cites W2012014117 @default.
- W3087180599 cites W2015133213 @default.
- W3087180599 cites W2020432830 @default.
- W3087180599 cites W2024979348 @default.
- W3087180599 cites W2025221238 @default.
- W3087180599 cites W2030637794 @default.
- W3087180599 cites W2032362466 @default.
- W3087180599 cites W2034087770 @default.
- W3087180599 cites W2035245572 @default.
- W3087180599 cites W2043395915 @default.
- W3087180599 cites W2044963576 @default.
- W3087180599 cites W2046237540 @default.
- W3087180599 cites W2050653572 @default.
- W3087180599 cites W2053402817 @default.
- W3087180599 cites W2054490148 @default.
- W3087180599 cites W2055022577 @default.
- W3087180599 cites W2055572268 @default.
- W3087180599 cites W2058153670 @default.
- W3087180599 cites W2061764676 @default.
- W3087180599 cites W2066575706 @default.
- W3087180599 cites W2071316675 @default.
- W3087180599 cites W2073084630 @default.
- W3087180599 cites W2076993988 @default.
- W3087180599 cites W2077546705 @default.
- W3087180599 cites W2081253095 @default.
- W3087180599 cites W2083149818 @default.
- W3087180599 cites W2084344997 @default.
- W3087180599 cites W2091095051 @default.
- W3087180599 cites W2094585531 @default.
- W3087180599 cites W2095652212 @default.
- W3087180599 cites W2104412320 @default.
- W3087180599 cites W2108326484 @default.
- W3087180599 cites W2112078762 @default.
- W3087180599 cites W2113729748 @default.
- W3087180599 cites W2115021528 @default.
- W3087180599 cites W2130893307 @default.
- W3087180599 cites W2131735196 @default.
- W3087180599 cites W2135309234 @default.
- W3087180599 cites W2137258759 @default.
- W3087180599 cites W2138438738 @default.
- W3087180599 cites W2141188578 @default.
- W3087180599 cites W2142639362 @default.
- W3087180599 cites W2148819754 @default.
- W3087180599 cites W2149090315 @default.
- W3087180599 cites W2155015733 @default.
- W3087180599 cites W2162660025 @default.
- W3087180599 cites W2162798718 @default.
- W3087180599 cites W2166398017 @default.
- W3087180599 cites W2166798527 @default.
- W3087180599 cites W2168082049 @default.
- W3087180599 cites W2168750058 @default.
- W3087180599 cites W2170942278 @default.
- W3087180599 cites W2171213306 @default.
- W3087180599 cites W2173276475 @default.
- W3087180599 cites W2186763432 @default.
- W3087180599 cites W2228112505 @default.
- W3087180599 cites W2234800739 @default.
- W3087180599 cites W2317798815 @default.
- W3087180599 cites W2336025467 @default.
- W3087180599 cites W2340872097 @default.
- W3087180599 cites W2496437652 @default.
- W3087180599 cites W2498411827 @default.
- W3087180599 cites W2512832185 @default.
- W3087180599 cites W2515920663 @default.
- W3087180599 cites W2519360406 @default.