Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087198522> ?p ?o ?g. }
- W3087198522 endingPage "188432" @default.
- W3087198522 startingPage "188432" @default.
- W3087198522 abstract "Protein tyrosine kinase 6 (PTK6) is the most well studied member of the PTK6 family of intracellular tyrosine kinases. While it is expressed at highest levels in differentiated cells in the regenerating epithelial linings of the gastrointestinal tract and skin, induction and activation of PTK6 is detected in several cancers, including breast and prostate cancer where high PTK6 expression correlates with worse outcome. PTK6 expression is regulated by hypoxia and cell stress, and its kinase activity is induced by several growth factor receptors implicated in cancer including members of the ERBB family, IGFR1 and MET. Activation of PTK6 at the plasma membrane has been associated with the epithelial mesenchymal transition and tumor metastasis. Several lines of evidence indicate that PTK6 has context dependent functions that depend on cell type, intracellular localization and kinase activation. Systemic disruption of PTK6 has been shown to reduce tumorigenesis in mouse models of breast and prostate cancer, and more recently small molecule inhibitors of PTK6 have exhibited efficacy in inhibiting tumor growth in animal models. Here we review data that suggest targeting PTK6 may have beneficial therapeutic outcomes in some cancers." @default.
- W3087198522 created "2020-09-25" @default.
- W3087198522 creator A5032118023 @default.
- W3087198522 creator A5034631702 @default.
- W3087198522 date "2020-12-01" @default.
- W3087198522 modified "2023-09-24" @default.
- W3087198522 title "Targeting protein tyrosine kinase 6 in cancer" @default.
- W3087198522 cites W101157884 @default.
- W3087198522 cites W1056262909 @default.
- W3087198522 cites W1521732454 @default.
- W3087198522 cites W167109117 @default.
- W3087198522 cites W1880105352 @default.
- W3087198522 cites W1960289620 @default.
- W3087198522 cites W1965395090 @default.
- W3087198522 cites W1967150229 @default.
- W3087198522 cites W1972056952 @default.
- W3087198522 cites W1972424044 @default.
- W3087198522 cites W1975146254 @default.
- W3087198522 cites W1979880724 @default.
- W3087198522 cites W1984903084 @default.
- W3087198522 cites W1985554836 @default.
- W3087198522 cites W1986139301 @default.
- W3087198522 cites W1986283944 @default.
- W3087198522 cites W1988639501 @default.
- W3087198522 cites W1991314258 @default.
- W3087198522 cites W1992346696 @default.
- W3087198522 cites W1996164779 @default.
- W3087198522 cites W1996223901 @default.
- W3087198522 cites W2003356040 @default.
- W3087198522 cites W2003611681 @default.
- W3087198522 cites W2003938320 @default.
- W3087198522 cites W2003973314 @default.
- W3087198522 cites W2006344933 @default.
- W3087198522 cites W2009516966 @default.
- W3087198522 cites W2014445008 @default.
- W3087198522 cites W2015398745 @default.
- W3087198522 cites W2019119828 @default.
- W3087198522 cites W2019891499 @default.
- W3087198522 cites W2022614256 @default.
- W3087198522 cites W2022696262 @default.
- W3087198522 cites W2029945172 @default.
- W3087198522 cites W2032840254 @default.
- W3087198522 cites W2034520315 @default.
- W3087198522 cites W2034986953 @default.
- W3087198522 cites W2035444570 @default.
- W3087198522 cites W2038350276 @default.
- W3087198522 cites W2040053929 @default.
- W3087198522 cites W2040257806 @default.
- W3087198522 cites W2041927438 @default.
- W3087198522 cites W2043758280 @default.
- W3087198522 cites W2043789128 @default.
- W3087198522 cites W2044079490 @default.
- W3087198522 cites W2045009938 @default.
- W3087198522 cites W2047613522 @default.
- W3087198522 cites W2051232673 @default.
- W3087198522 cites W2051871861 @default.
- W3087198522 cites W2054238123 @default.
- W3087198522 cites W2057100766 @default.
- W3087198522 cites W2058479792 @default.
- W3087198522 cites W2061206375 @default.
- W3087198522 cites W2063294706 @default.
- W3087198522 cites W2064041964 @default.
- W3087198522 cites W2070443323 @default.
- W3087198522 cites W2071437006 @default.
- W3087198522 cites W2072440152 @default.
- W3087198522 cites W2074093530 @default.
- W3087198522 cites W2074176106 @default.
- W3087198522 cites W2076074060 @default.
- W3087198522 cites W2077147668 @default.
- W3087198522 cites W2078272872 @default.
- W3087198522 cites W2081802382 @default.
- W3087198522 cites W2082202424 @default.
- W3087198522 cites W2082270030 @default.
- W3087198522 cites W2083241637 @default.
- W3087198522 cites W2084055030 @default.
- W3087198522 cites W2089457213 @default.
- W3087198522 cites W2089868519 @default.
- W3087198522 cites W2089925178 @default.
- W3087198522 cites W2093780541 @default.
- W3087198522 cites W2094021507 @default.
- W3087198522 cites W2097489402 @default.
- W3087198522 cites W2099473143 @default.
- W3087198522 cites W2101635775 @default.
- W3087198522 cites W2101909769 @default.
- W3087198522 cites W2104222404 @default.
- W3087198522 cites W2104670314 @default.
- W3087198522 cites W2105719222 @default.
- W3087198522 cites W2114843025 @default.
- W3087198522 cites W2116034419 @default.
- W3087198522 cites W2118895328 @default.
- W3087198522 cites W2120772351 @default.
- W3087198522 cites W2121175301 @default.
- W3087198522 cites W2122653717 @default.
- W3087198522 cites W2124929807 @default.
- W3087198522 cites W2125244982 @default.
- W3087198522 cites W2125921526 @default.
- W3087198522 cites W2127254281 @default.
- W3087198522 cites W2129326357 @default.