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- W3087201309 abstract "Abstract The repair of a cartilage lesion with a hydrogel requires a method for long‐term fixation of the hydrogel in the defect site. Attachment of a hydrogel to a base that allows for integration with bone can enable long‐term fixation of the hydrogel, but current methods of forming bonds to hydrogels have less than a tenth of the shear strength of the osteochondral junction. This communication describes a new method, nanofiber‐enhanced sticking (NEST), for bonding a hydrogel to a base with an adhesive shear strength three times larger than the state‐of‐the‐art. An example of NEST is described in which a nanofibrous bacterial cellulose sheet is bonded to a porous base with a hydroxyapatite‐forming cement followed by infiltration of the nanofibrous sheet with hydrogel‐forming polymeric materials. This approach creates a mineralized nanofiber bond that mimics the structure of the osteochondral junction, in which collagen nanofibers extend from cartilage into a mineralized region that anchors cartilage to bone." @default.
- W3087201309 created "2020-09-25" @default.
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- W3087201309 date "2020-09-16" @default.
- W3087201309 modified "2023-09-24" @default.
- W3087201309 title "High‐Strength Hydrogel Attachment through Nanofibrous Reinforcement" @default.
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- W3087201309 doi "https://doi.org/10.1002/adhm.202001119" @default.
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