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• W3087206721 abstract "Abstract Study Objectives Estimate the genetic relationship of cannabis use with sleep deficits and an eveningness chronotype. Methods We used linkage disequilibrium score regression (LDSC) to analyze genetic correlations between sleep deficits and cannabis use behaviors. Secondly, we generated sleep deficit polygenic risk score (PRS) and estimated their ability to predict cannabis use behaviors using linear and logistic regression. Summary statistics came from existing genome-wide association studies of European ancestry that were focused on sleep duration, insomnia, chronotype, lifetime cannabis use, and cannabis use disorder (CUD). A target sample for PRS prediction consisted of high-risk participants and participants from twin/family community-based studies (European ancestry; n = 760, male = 64%; mean age = 26.78 years). Target data consisted of self-reported sleep (sleep duration, feeling tired, and taking naps) and cannabis use behaviors (lifetime ever use, number of lifetime uses, past 180-day use, age of first use, and lifetime CUD symptoms). Results Significant genetic correlation between lifetime cannabis use and an eveningness chronotype (rG = 0.24, p &lt; 0.001), as well as between CUD and both short sleep duration (&lt;7 h; rG = 0.23, p = 0.017) and insomnia (rG = 0.20, p = 0.020). Insomnia PRS predicted earlier age of first cannabis use (OR = 0.92, p = 0.036) and increased lifetime CUD symptom count (OR = 1.09, p = 0.012). Conclusion Cannabis use is genetically associated with both sleep deficits and an eveningness chronotype, suggesting that there are genes that predispose individuals to both cannabis use and sleep deficits." @default.
• W3087206721 created "2020-09-25" @default.
• W3087206721 creator A5009321137 @default.
• W3087206721 creator A5013198315 @default.
• W3087206721 creator A5017046391 @default.
• W3087206721 creator A5017206949 @default.
• W3087206721 creator A5043089914 @default.
• W3087206721 creator A5065331698 @default.
• W3087206721 creator A5066340293 @default.
• W3087206721 creator A5091070121 @default.
• W3087206721 date "2020-09-16" @default.
• W3087206721 modified "2023-10-14" @default.
• W3087206721 title "Sleep deficits and cannabis use behaviors: an analysis of shared genetics using linkage disequilibrium score regression and polygenic risk prediction" @default.
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