Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087206871> ?p ?o ?g. }
- W3087206871 endingPage "370" @default.
- W3087206871 startingPage "355" @default.
- W3087206871 abstract "Abstract Increasing crop productivity is our major challenge if we are to meet global needs for food, fodder and fuel. Controlling the content of the plant hormone cytokinin is a method of improving plant productivity. Cytokinin oxidase/dehydrogenase (CKO/CKX) is a major target in this regard because it degrades cytokinins. Here, we describe the synthesis and biological activities of new CKX inhibitors derived mainly from diphenylurea. They were tested on four CKX isoforms from maize and Arabidopsis, where the best compounds showed IC50 values in the 10–8 M concentration range. The binding mode of the most efficient inhibitors was characterized from high-resolution crystal complexed structures. Although these compounds do not possess intrinsic cytokinin activity, we have demonstrated their tremendous potential for use in the plant tissue culture industry as well as in agriculture. We have identified a key substance, compound 19, which not only increases stress resistance and seed yield in Arabidopsis, but also improves the yield of wheat, barley and rapeseed grains under field conditions. Our findings reveal that modulation of cytokinin levels via CKX inhibition can positively affect plant growth, development and yield, and prove that CKX inhibitors can be an attractive target in plant biotechnology and agriculture." @default.
- W3087206871 created "2020-09-25" @default.
- W3087206871 creator A5017292086 @default.
- W3087206871 creator A5021868007 @default.
- W3087206871 creator A5022388863 @default.
- W3087206871 creator A5034638943 @default.
- W3087206871 creator A5037226850 @default.
- W3087206871 creator A5041853000 @default.
- W3087206871 creator A5047064184 @default.
- W3087206871 creator A5053576191 @default.
- W3087206871 creator A5061028043 @default.
- W3087206871 creator A5069622703 @default.
- W3087206871 creator A5074102855 @default.
- W3087206871 creator A5074231412 @default.
- W3087206871 creator A5075699649 @default.
- W3087206871 creator A5076048751 @default.
- W3087206871 creator A5080099250 @default.
- W3087206871 creator A5085097439 @default.
- W3087206871 date "2020-09-18" @default.
- W3087206871 modified "2023-10-16" @default.
- W3087206871 title "Diphenylurea-derived cytokinin oxidase/dehydrogenase inhibitors for biotechnology and agriculture" @default.
- W3087206871 cites W121238022 @default.
- W3087206871 cites W1229029319 @default.
- W3087206871 cites W1518005836 @default.
- W3087206871 cites W1664406514 @default.
- W3087206871 cites W1833159633 @default.
- W3087206871 cites W1965002026 @default.
- W3087206871 cites W1971304255 @default.
- W3087206871 cites W1972379843 @default.
- W3087206871 cites W1979047342 @default.
- W3087206871 cites W1984643518 @default.
- W3087206871 cites W1991236177 @default.
- W3087206871 cites W1992372626 @default.
- W3087206871 cites W2006944381 @default.
- W3087206871 cites W2008333138 @default.
- W3087206871 cites W2008708467 @default.
- W3087206871 cites W2016765195 @default.
- W3087206871 cites W2019079949 @default.
- W3087206871 cites W2021231653 @default.
- W3087206871 cites W2030356145 @default.
- W3087206871 cites W2036351251 @default.
- W3087206871 cites W2038416876 @default.
- W3087206871 cites W2041275089 @default.
- W3087206871 cites W2042667559 @default.
- W3087206871 cites W2043409652 @default.
- W3087206871 cites W2044816862 @default.
- W3087206871 cites W2047440943 @default.
- W3087206871 cites W2054118120 @default.
- W3087206871 cites W2059551106 @default.
- W3087206871 cites W2063229776 @default.
- W3087206871 cites W2063644562 @default.
- W3087206871 cites W2078644000 @default.
- W3087206871 cites W2080403208 @default.
- W3087206871 cites W2082891324 @default.
- W3087206871 cites W2087165791 @default.
- W3087206871 cites W2088035830 @default.
- W3087206871 cites W2088251339 @default.
- W3087206871 cites W2088563322 @default.
- W3087206871 cites W2094353079 @default.
- W3087206871 cites W2095053401 @default.
- W3087206871 cites W2108959691 @default.
- W3087206871 cites W2112790775 @default.
- W3087206871 cites W2114522764 @default.
- W3087206871 cites W2144081223 @default.
- W3087206871 cites W2146003651 @default.
- W3087206871 cites W2149609455 @default.
- W3087206871 cites W2154714625 @default.
- W3087206871 cites W2167631864 @default.
- W3087206871 cites W2168973416 @default.
- W3087206871 cites W2192147494 @default.
- W3087206871 cites W22835931 @default.
- W3087206871 cites W2327150661 @default.
- W3087206871 cites W2472927473 @default.
- W3087206871 cites W2589883070 @default.
- W3087206871 cites W2789653803 @default.
- W3087206871 cites W2890107651 @default.
- W3087206871 cites W2902104204 @default.
- W3087206871 cites W2945681672 @default.
- W3087206871 cites W3039083828 @default.
- W3087206871 cites W4211082597 @default.
- W3087206871 cites W4237308090 @default.
- W3087206871 cites W4248872320 @default.
- W3087206871 cites W616132717 @default.
- W3087206871 doi "https://doi.org/10.1093/jxb/eraa437" @default.
- W3087206871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32945834" @default.
- W3087206871 hasPublicationYear "2020" @default.
- W3087206871 type Work @default.
- W3087206871 sameAs 3087206871 @default.
- W3087206871 citedByCount "24" @default.
- W3087206871 countsByYear W30872068712020 @default.
- W3087206871 countsByYear W30872068712021 @default.
- W3087206871 countsByYear W30872068712022 @default.
- W3087206871 countsByYear W30872068712023 @default.
- W3087206871 crossrefType "journal-article" @default.
- W3087206871 hasAuthorship W3087206871A5017292086 @default.
- W3087206871 hasAuthorship W3087206871A5021868007 @default.
- W3087206871 hasAuthorship W3087206871A5022388863 @default.
- W3087206871 hasAuthorship W3087206871A5034638943 @default.