Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087210026> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W3087210026 endingPage "1248" @default.
- W3087210026 startingPage "1245" @default.
- W3087210026 abstract "Summary Uveal melanoma is the most common form of eye cancer and has a poor prognosis. Although the primary tumor in most cases is treated effectively by local surgery or radiotherapy, over 50 % of patients develop systemic metastasis, especially in the liver. In contrast to cutaneous melanoma, there is no standard‐of‐care treatment for metastasized uveal melanoma. Recently, oncogenic driver mutations in GNAQ or GNA11 were identified in about 85 % of uveal melanomas, which lead to constitutively active signaling in the Gα q/11 pathway and its downstream effectors. Direct targeting of deregulated Gα q/11 signaling might therefore be a therapeutic option for patients with uveal melanoma. In our study we identified the cyclic depsipeptide FR‐900359, which is isolated from the evergreen plant Ardisia crenata as an effective inhibitor of constitutively active Gα q/11 proteins and their downstream targets. Although our data are preliminary, they might contribute to a future treatment option for patients with metastasized uveal melanoma." @default.
- W3087210026 created "2020-09-25" @default.
- W3087210026 creator A5037908822 @default.
- W3087210026 date "2020-09-21" @default.
- W3087210026 modified "2023-09-26" @default.
- W3087210026 title "Research in practice: Therapeutic targeting of oncogenic<i>GNAQ</i>mutations in uveal melanoma" @default.
- W3087210026 cites W2004871593 @default.
- W3087210026 cites W2005647807 @default.
- W3087210026 cites W2008322756 @default.
- W3087210026 cites W2009931937 @default.
- W3087210026 cites W2017316435 @default.
- W3087210026 cites W2038434969 @default.
- W3087210026 cites W2038709562 @default.
- W3087210026 cites W2039094079 @default.
- W3087210026 cites W2039939270 @default.
- W3087210026 cites W2053520756 @default.
- W3087210026 cites W2055835855 @default.
- W3087210026 cites W2077551961 @default.
- W3087210026 cites W2100554784 @default.
- W3087210026 cites W2109536183 @default.
- W3087210026 cites W2140975775 @default.
- W3087210026 cites W2157151684 @default.
- W3087210026 cites W2259804540 @default.
- W3087210026 cites W2419151784 @default.
- W3087210026 cites W2535591177 @default.
- W3087210026 cites W2559127842 @default.
- W3087210026 cites W2589890469 @default.
- W3087210026 cites W2793005533 @default.
- W3087210026 cites W2890746219 @default.
- W3087210026 cites W2904787599 @default.
- W3087210026 cites W2922555277 @default.
- W3087210026 cites W3009596360 @default.
- W3087210026 doi "https://doi.org/10.1111/ddg.14288" @default.
- W3087210026 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32954611" @default.
- W3087210026 hasPublicationYear "2020" @default.
- W3087210026 type Work @default.
- W3087210026 sameAs 3087210026 @default.
- W3087210026 citedByCount "2" @default.
- W3087210026 countsByYear W30872100262021 @default.
- W3087210026 crossrefType "journal-article" @default.
- W3087210026 hasAuthorship W3087210026A5037908822 @default.
- W3087210026 hasConcept C104317684 @default.
- W3087210026 hasConcept C121608353 @default.
- W3087210026 hasConcept C126322002 @default.
- W3087210026 hasConcept C143998085 @default.
- W3087210026 hasConcept C2777658100 @default.
- W3087210026 hasConcept C2779013556 @default.
- W3087210026 hasConcept C2779176653 @default.
- W3087210026 hasConcept C501734568 @default.
- W3087210026 hasConcept C502942594 @default.
- W3087210026 hasConcept C509974204 @default.
- W3087210026 hasConcept C55493867 @default.
- W3087210026 hasConcept C71924100 @default.
- W3087210026 hasConcept C86803240 @default.
- W3087210026 hasConceptScore W3087210026C104317684 @default.
- W3087210026 hasConceptScore W3087210026C121608353 @default.
- W3087210026 hasConceptScore W3087210026C126322002 @default.
- W3087210026 hasConceptScore W3087210026C143998085 @default.
- W3087210026 hasConceptScore W3087210026C2777658100 @default.
- W3087210026 hasConceptScore W3087210026C2779013556 @default.
- W3087210026 hasConceptScore W3087210026C2779176653 @default.
- W3087210026 hasConceptScore W3087210026C501734568 @default.
- W3087210026 hasConceptScore W3087210026C502942594 @default.
- W3087210026 hasConceptScore W3087210026C509974204 @default.
- W3087210026 hasConceptScore W3087210026C55493867 @default.
- W3087210026 hasConceptScore W3087210026C71924100 @default.
- W3087210026 hasConceptScore W3087210026C86803240 @default.
- W3087210026 hasIssue "11" @default.
- W3087210026 hasLocation W30872100261 @default.
- W3087210026 hasOpenAccess W3087210026 @default.
- W3087210026 hasPrimaryLocation W30872100261 @default.
- W3087210026 hasRelatedWork W2141202463 @default.
- W3087210026 hasRelatedWork W2331606468 @default.
- W3087210026 hasRelatedWork W2413189820 @default.
- W3087210026 hasRelatedWork W2623003466 @default.
- W3087210026 hasRelatedWork W2747570594 @default.
- W3087210026 hasRelatedWork W2774165137 @default.
- W3087210026 hasRelatedWork W3126366955 @default.
- W3087210026 hasRelatedWork W4362493042 @default.
- W3087210026 hasRelatedWork W4362495258 @default.
- W3087210026 hasRelatedWork W4386165003 @default.
- W3087210026 hasVolume "18" @default.
- W3087210026 isParatext "false" @default.
- W3087210026 isRetracted "false" @default.
- W3087210026 magId "3087210026" @default.
- W3087210026 workType "article" @default.