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- W3087260902 endingPage "100903" @default.
- W3087260902 startingPage "100903" @default.
- W3087260902 abstract "Vascular basement membrane (BM) thickening has been hailed over half a century as the most prominent histological lesion in diabetic microangiopathy, and represents an early ultrastructural change in diabetic retinopathy (DR). Although vascular complications of DR have been clinically well established, specific cellular and molecular mechanisms underlying dysfunction of small vessels are not well understood. In DR, small vessels develop insidiously as BM thickening occurs. Studies examining high resolution imaging data have established BM thickening as one of the foremost structural abnormalities of retinal capillaries. This fundamental structural change develops, at least in part, from excess accumulation of BM components. Although BM thickening is closely associated with the development of DR, its contributory role in the pathogenesis of DR is coming to light recently. DR develops over several years before clinical manifestations appear, and it is during this clinically silent period that hyperglycemia induces excess synthesis of BM components, contributes to vascular BM thickening, and promotes structural and functional lesions including cell death and vascular leakage in the diabetic retina. Studies using animal models show promising results in preventing BM thickening with subsequent beneficial effects. Several gene regulatory approaches are being developed to prevent excess synthesis of vascular BM components in an effort to reduce BM thickening. This review highlights current understanding of capillary BM thickening development, role of BM thickening in retinal vascular lesions, and strategies for preventing vascular BM thickening as a potential therapeutic strategy in alleviating characteristic lesions associated with DR." @default.
- W3087260902 created "2020-09-25" @default.
- W3087260902 creator A5009364745 @default.
- W3087260902 creator A5085497567 @default.
- W3087260902 date "2021-05-01" @default.
- W3087260902 modified "2023-09-29" @default.
- W3087260902 title "Retinal capillary basement membrane thickening: Role in the pathogenesis of diabetic retinopathy" @default.
- W3087260902 cites W104787734 @default.
- W3087260902 cites W114934927 @default.
- W3087260902 cites W1195096975 @default.
- W3087260902 cites W138935070 @default.
- W3087260902 cites W145532302 @default.
- W3087260902 cites W1515072532 @default.
- W3087260902 cites W1515444240 @default.
- W3087260902 cites W1518099827 @default.
- W3087260902 cites W1520299912 @default.
- W3087260902 cites W153793406 @default.
- W3087260902 cites W1549624320 @default.
- W3087260902 cites W1560501046 @default.
- W3087260902 cites W1569256916 @default.
- W3087260902 cites W1576773659 @default.
- W3087260902 cites W1594288804 @default.
- W3087260902 cites W1597144400 @default.
- W3087260902 cites W1597652886 @default.
- W3087260902 cites W163741303 @default.
- W3087260902 cites W164895742 @default.
- W3087260902 cites W1669512483 @default.
- W3087260902 cites W1779563193 @default.
- W3087260902 cites W180946660 @default.
- W3087260902 cites W1881787419 @default.
- W3087260902 cites W1964201932 @default.
- W3087260902 cites W1964738126 @default.
- W3087260902 cites W1965722557 @default.
- W3087260902 cites W1966276445 @default.
- W3087260902 cites W1967429010 @default.
- W3087260902 cites W1967605282 @default.
- W3087260902 cites W1968263187 @default.
- W3087260902 cites W1968415431 @default.
- W3087260902 cites W1969353313 @default.
- W3087260902 cites W1976442335 @default.
- W3087260902 cites W1976633649 @default.
- W3087260902 cites W1976698982 @default.
- W3087260902 cites W1977395180 @default.
- W3087260902 cites W1977785904 @default.
- W3087260902 cites W1977855971 @default.
- W3087260902 cites W1977930195 @default.
- W3087260902 cites W1978299468 @default.
- W3087260902 cites W1978414192 @default.
- W3087260902 cites W1978444547 @default.
- W3087260902 cites W1978494660 @default.
- W3087260902 cites W1979234661 @default.
- W3087260902 cites W1981411389 @default.
- W3087260902 cites W1982830057 @default.
- W3087260902 cites W1984872320 @default.
- W3087260902 cites W1985578923 @default.
- W3087260902 cites W1986613552 @default.
- W3087260902 cites W1988447189 @default.
- W3087260902 cites W1990772856 @default.
- W3087260902 cites W1991839861 @default.
- W3087260902 cites W1992425768 @default.
- W3087260902 cites W1993607801 @default.
- W3087260902 cites W1993732948 @default.
- W3087260902 cites W1994717072 @default.
- W3087260902 cites W1995494201 @default.
- W3087260902 cites W1995887805 @default.
- W3087260902 cites W1999644982 @default.
- W3087260902 cites W2001644356 @default.
- W3087260902 cites W200264850 @default.
- W3087260902 cites W2002771508 @default.
- W3087260902 cites W2006241828 @default.
- W3087260902 cites W2006477603 @default.
- W3087260902 cites W2007156774 @default.
- W3087260902 cites W2009211481 @default.
- W3087260902 cites W2009343046 @default.
- W3087260902 cites W2013514969 @default.
- W3087260902 cites W2015105035 @default.
- W3087260902 cites W2016103347 @default.
- W3087260902 cites W2017313337 @default.
- W3087260902 cites W2018244125 @default.
- W3087260902 cites W2018395653 @default.
- W3087260902 cites W2020648851 @default.
- W3087260902 cites W2025456767 @default.
- W3087260902 cites W2026159950 @default.
- W3087260902 cites W2027288287 @default.
- W3087260902 cites W2027518088 @default.
- W3087260902 cites W2027767729 @default.
- W3087260902 cites W2028223775 @default.
- W3087260902 cites W2028256138 @default.
- W3087260902 cites W2028943633 @default.
- W3087260902 cites W2029231027 @default.
- W3087260902 cites W2030404075 @default.
- W3087260902 cites W203149433 @default.
- W3087260902 cites W2031856001 @default.
- W3087260902 cites W2033115357 @default.
- W3087260902 cites W2033294379 @default.
- W3087260902 cites W2034244905 @default.
- W3087260902 cites W2034716285 @default.
- W3087260902 cites W2035899769 @default.