FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087270406> ?p ?o ?g. }

• W3087270406 endingPage "144" @default.
• W3087270406 startingPage "133" @default.
• W3087270406 abstract "The main cause of gastric cancer is the infection by the bacterium Helicobacter pylori which induces a chronic inflammation and an epithelial-to-mesenchymal transition (EMT) leading to the emergence of cells with cancer stem cell (CSC) properties. However, the underlying mechanisms have not been fully characterized. Moreover, H. pylori modulates the host cell autophagic process, but a few studies have investigated the role of this process in tumoral transformation. The aim of this study was to determine whether H. pylori-induced autophagy has a role in CSC emergence. Autophagic flux in response to H. pylori infection was characterized in AGS cell line expressing the tandem-tagged mCherry-GFP-LC3 protein and using a ratiometric flow cytometry analysis. Then, AGS and MKN45 cell lines were treated with bafilomycin or chloroquine, two pharmaceutical well-known inhibitors of autophagy, and different EMT and CSC characteristics were analyzed. First, a co-expression of the gastric CSC marker CD44 and the autophagic marker LC3 in mice and human stomach tissues infected with H. pylori was observed. Then, we demonstrated in vitro that H. pylori was able to activate the autophagy process with a reduced autophagic flux. Finally, infected cells were treated with autophagy inhibitors, which reduced (i) appearance of mesenchymal phenotypes and migration ability related to EMT and (ii) CD44 expression as well as tumorsphere formation capacities reflecting CSC properties. In conclusion, all these data show that H. pylori-induced autophagy is implicated in gastric CSC emergence and could represent an interesting therapeutic target." @default.
• W3087270406 created "2020-09-25" @default.
• W3087270406 creator A5001297230 @default.
• W3087270406 creator A5017296018 @default.
• W3087270406 creator A5045528390 @default.
• W3087270406 creator A5047960821 @default.
• W3087270406 creator A5050209583 @default.
• W3087270406 creator A5060734951 @default.
• W3087270406 creator A5064886520 @default.
• W3087270406 creator A5073891040 @default.
• W3087270406 creator A5075200875 @default.
• W3087270406 creator A5080466170 @default.
• W3087270406 creator A5087318648 @default.
• W3087270406 date "2020-09-17" @default.
• W3087270406 modified "2023-10-13" @default.
• W3087270406 title "Autophagy induced by Helicobacter pylori infection is necessary for gastric cancer stem cell emergence" @default.
• W3087270406 cites W1986802187 @default.
• W3087270406 cites W1989051519 @default.
• W3087270406 cites W1994968854 @default.
• W3087270406 cites W1999211990 @default.
• W3087270406 cites W2003047659 @default.
• W3087270406 cites W2008181873 @default.
• W3087270406 cites W2024520801 @default.
• W3087270406 cites W2045122835 @default.
• W3087270406 cites W2050165541 @default.
• W3087270406 cites W2056934197 @default.
• W3087270406 cites W2063761428 @default.
• W3087270406 cites W2067683713 @default.
• W3087270406 cites W2071297128 @default.
• W3087270406 cites W2077731318 @default.
• W3087270406 cites W2085258486 @default.
• W3087270406 cites W2089586603 @default.
• W3087270406 cites W2089728480 @default.
• W3087270406 cites W2102085111 @default.
• W3087270406 cites W2129336819 @default.
• W3087270406 cites W2154589460 @default.
• W3087270406 cites W2176514435 @default.
• W3087270406 cites W2179132463 @default.
• W3087270406 cites W2281792370 @default.
• W3087270406 cites W2324287117 @default.
• W3087270406 cites W2346533061 @default.
• W3087270406 cites W2415786957 @default.
• W3087270406 cites W2529795203 @default.
• W3087270406 cites W2575944594 @default.
• W3087270406 cites W2588451433 @default.
• W3087270406 cites W2601778356 @default.
• W3087270406 cites W2609752905 @default.
• W3087270406 cites W2613581754 @default.
• W3087270406 cites W2735762029 @default.
• W3087270406 cites W2748137738 @default.
• W3087270406 cites W2757000816 @default.
• W3087270406 cites W2758138488 @default.
• W3087270406 cites W2764307204 @default.
• W3087270406 cites W2892236602 @default.
• W3087270406 cites W2900688229 @default.
• W3087270406 cites W2900750994 @default.
• W3087270406 cites W2911996535 @default.
• W3087270406 cites W2923831676 @default.
• W3087270406 cites W2945047925 @default.
• W3087270406 cites W2946952881 @default.
• W3087270406 cites W2949460836 @default.
• W3087270406 cites W2952079594 @default.
• W3087270406 doi "https://doi.org/10.1007/s10120-020-01118-9" @default.
• W3087270406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32940810" @default.
• W3087270406 hasPublicationYear "2020" @default.
• W3087270406 type Work @default.
• W3087270406 sameAs 3087270406 @default.
• W3087270406 citedByCount "21" @default.
• W3087270406 countsByYear W30872704062021 @default.
• W3087270406 countsByYear W30872704062022 @default.
• W3087270406 countsByYear W30872704062023 @default.
• W3087270406 crossrefType "journal-article" @default.
• W3087270406 hasAuthorship W3087270406A5001297230 @default.
• W3087270406 hasAuthorship W3087270406A5017296018 @default.
• W3087270406 hasAuthorship W3087270406A5045528390 @default.
• W3087270406 hasAuthorship W3087270406A5047960821 @default.
• W3087270406 hasAuthorship W3087270406A5050209583 @default.
• W3087270406 hasAuthorship W3087270406A5060734951 @default.
• W3087270406 hasAuthorship W3087270406A5064886520 @default.
• W3087270406 hasAuthorship W3087270406A5073891040 @default.
• W3087270406 hasAuthorship W3087270406A5075200875 @default.
• W3087270406 hasAuthorship W3087270406A5080466170 @default.
• W3087270406 hasAuthorship W3087270406A5087318648 @default.
• W3087270406 hasBestOaLocation W30872704061 @default.
• W3087270406 hasConcept C121608353 @default.
• W3087270406 hasConcept C126322002 @default.
• W3087270406 hasConcept C190283241 @default.
• W3087270406 hasConcept C203522944 @default.
• W3087270406 hasConcept C2776409635 @default.
• W3087270406 hasConcept C2780140570 @default.
• W3087270406 hasConcept C2908868296 @default.
• W3087270406 hasConcept C54355233 @default.
• W3087270406 hasConcept C71924100 @default.
• W3087270406 hasConcept C86803240 @default.
• W3087270406 hasConceptScore W3087270406C121608353 @default.
• W3087270406 hasConceptScore W3087270406C126322002 @default.
• W3087270406 hasConceptScore W3087270406C190283241 @default.
• W3087270406 hasConceptScore W3087270406C203522944 @default.

• next