FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087276021> ?p ?o ?g. }

• W3087276021 abstract "Abstract Background Angiogenesis, a basic requirement for tumor cell survival, is considered to be a malignant characteristic of small cell lung cancer (SCLC) and is closely related to the poor outcomes of SCLC patients. miR-141 has been found to play pro- and antiangiogenic roles in different cancers, but its role in SCLC angiogenesis has never been explored. Methods Total RNA was isolated from plasm exosomes and serum of SCLC patients to examine the expression of miR-141 by qRT-PCR. Cell proliferation, invasion, migration, tube formation assay, aortic ring assay and mouse tumor model were used to investigate the effect of exosomal miR-141 in angiogenesis in vitro and in vivo. Dual-luciferase assay was conducted to explore the target gene of miR-141. Results Circulating miR-141 was upregulated in samples from 122 SCLC patients compared with those from normal volunteers and that the increase in miR-141 was significantly associated with advanced TNM stages, implying the potential oncogenic role of miR-141 in SCLC malignancy. In vitro, miR-141 that was packaged into SCLC cell-secreted exosomes and delivered to human umbilical vein vascular endothelial cells (HUVECs) via exosomes facilitated HUVEC proliferation, invasion, migration and tube formation and promoted microvessel sprouting from mouse aortic rings. Matrigel plug assays demonstrated that SCLC cell-derived exosomal miR-141 induced neoangiogenesis in vivo. Furthermore, mouse subcutaneous tumor nodules that were developed from miR-141-overexpressing SCLC cells had a higher microvessel density (MVD) and grew faster than those developed from negative control cells. KLF12 was found to be the direct target gene of miR-141 and that the proangiogenic effect of miR-141 on HUVECs was abrogated by KLF12 overexpression. Conclusions Our results demonstrate the specific function of the exosomal miR-141/KLF12 pathway in SCLC angiogenesis for the first time and provide potential novel targets for antiangiogenic therapies for SCLC patients." @default.
• W3087276021 created "2020-09-25" @default.
• W3087276021 creator A5013457441 @default.
• W3087276021 creator A5022692217 @default.
• W3087276021 creator A5027751473 @default.
• W3087276021 creator A5029227356 @default.
• W3087276021 creator A5034423792 @default.
• W3087276021 creator A5041722972 @default.
• W3087276021 creator A5049341927 @default.
• W3087276021 creator A5066534937 @default.
• W3087276021 creator A5067592367 @default.
• W3087276021 creator A5070812231 @default.
• W3087276021 creator A5076797215 @default.
• W3087276021 creator A5084184963 @default.
• W3087276021 date "2020-09-21" @default.
• W3087276021 modified "2023-10-11" @default.
• W3087276021 title "Exosomal miR-141 promotes tumor angiogenesis via KLF12 in small cell lung cancer" @default.
• W3087276021 cites W1974242642 @default.
• W3087276021 cites W1976324983 @default.
• W3087276021 cites W1987097208 @default.
• W3087276021 cites W2007881573 @default.
• W3087276021 cites W2018414855 @default.
• W3087276021 cites W2032630075 @default.
• W3087276021 cites W2078438655 @default.
• W3087276021 cites W2097681338 @default.
• W3087276021 cites W2102577577 @default.
• W3087276021 cites W2105549148 @default.
• W3087276021 cites W2117692326 @default.
• W3087276021 cites W2124473529 @default.
• W3087276021 cites W2137417501 @default.
• W3087276021 cites W2140103603 @default.
• W3087276021 cites W2162674813 @default.
• W3087276021 cites W2164561943 @default.
• W3087276021 cites W2169895170 @default.
• W3087276021 cites W2264436887 @default.
• W3087276021 cites W2272984102 @default.
• W3087276021 cites W2554247041 @default.
• W3087276021 cites W2576628557 @default.
• W3087276021 cites W2586697182 @default.
• W3087276021 cites W2597326745 @default.
• W3087276021 cites W2617007913 @default.
• W3087276021 cites W2719499442 @default.
• W3087276021 cites W2742133220 @default.
• W3087276021 cites W2743956930 @default.
• W3087276021 cites W2745487428 @default.
• W3087276021 cites W2765782352 @default.
• W3087276021 cites W2767133324 @default.
• W3087276021 cites W2783856602 @default.
• W3087276021 cites W2786514708 @default.
• W3087276021 cites W2833622183 @default.
• W3087276021 cites W2890601979 @default.
• W3087276021 cites W2900784569 @default.
• W3087276021 cites W2904628185 @default.
• W3087276021 cites W2911188335 @default.
• W3087276021 cites W2926998048 @default.
• W3087276021 cites W2946141250 @default.
• W3087276021 cites W2947454698 @default.
• W3087276021 cites W2947771607 @default.
• W3087276021 cites W2969523340 @default.
• W3087276021 cites W2990709965 @default.
• W3087276021 cites W4239752473 @default.
• W3087276021 doi "https://doi.org/10.1186/s13046-020-01680-1" @default.
• W3087276021 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7504642" @default.
• W3087276021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32958011" @default.
• W3087276021 hasPublicationYear "2020" @default.
• W3087276021 type Work @default.
• W3087276021 sameAs 3087276021 @default.
• W3087276021 citedByCount "41" @default.
• W3087276021 countsByYear W30872760212021 @default.
• W3087276021 countsByYear W30872760212022 @default.
• W3087276021 countsByYear W30872760212023 @default.
• W3087276021 crossrefType "journal-article" @default.
• W3087276021 hasAuthorship W3087276021A5013457441 @default.
• W3087276021 hasAuthorship W3087276021A5022692217 @default.
• W3087276021 hasAuthorship W3087276021A5027751473 @default.
• W3087276021 hasAuthorship W3087276021A5029227356 @default.
• W3087276021 hasAuthorship W3087276021A5034423792 @default.
• W3087276021 hasAuthorship W3087276021A5041722972 @default.
• W3087276021 hasAuthorship W3087276021A5049341927 @default.
• W3087276021 hasAuthorship W3087276021A5066534937 @default.
• W3087276021 hasAuthorship W3087276021A5067592367 @default.
• W3087276021 hasAuthorship W3087276021A5070812231 @default.
• W3087276021 hasAuthorship W3087276021A5076797215 @default.
• W3087276021 hasAuthorship W3087276021A5084184963 @default.
• W3087276021 hasBestOaLocation W30872760211 @default.
• W3087276021 hasConcept C104317684 @default.
• W3087276021 hasConcept C121608353 @default.
• W3087276021 hasConcept C123012128 @default.
• W3087276021 hasConcept C126322002 @default.
• W3087276021 hasConcept C137738243 @default.
• W3087276021 hasConcept C142724271 @default.
• W3087276021 hasConcept C145059251 @default.
• W3087276021 hasConcept C1491633281 @default.
• W3087276021 hasConcept C150903083 @default.
• W3087276021 hasConcept C202751555 @default.
• W3087276021 hasConcept C20518536 @default.
• W3087276021 hasConcept C207001950 @default.
• W3087276021 hasConcept C2776436680 @default.
• W3087276021 hasConcept C2777411675 @default.
• W3087276021 hasConcept C2777834122 @default.

• next