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• W3087333470 endingPage "147127" @default.
• W3087333470 startingPage "147127" @default.
• W3087333470 abstract "Alzheimer's disease (AD) is one of the most common forms of dementia with still unknown pathogenesis. Several cytokines and chemokines are involved in the pathogenesis of AD. Among the chemokines, the CXCR4/CXCL12 complex has been shown to play an important role in the pathogenetic development of AD. We investigated the expression levels of CXCR4 / CXCL12 in fifteen brain regions of healthy non-demented subjects (NDHC) (2139 sample) and AD patients (1170 sample) stratified according to sex and age. Furthermore, we correlated their expressions with the Neurogranin (NRGN) and CHI3L1 levels, two inflamm-aging markers. We highlighted that CXCR4 gene expression levels were age-correlated in the brain of NDHC subjects and that AD nullified this correlation. A similar trend, but diametrically opposite was observed for CXCL12. Its expression was decreased during the aging in both sexes, and in the brains of AD patients, it underwent an inversion of the trend, only and exclusively in females. Brains of AD patients expressed high CXCR4 and CHI3L1, and low CXCL12 and Neurogranin levels compared to NDHC subjects. Both CXCR4 and CXCL12 correlated significantly with CHI3L1 and Neurogranin expression levels, regardless of disease. Furthermore, we showed a selective modulation of CXCL12 and CXCR4 only in specific brain regions. Taken together our results demonstrate that CXCL12 and CXCR4 are linked to Neurogranin and CHI3L1 expression levels and the relationship between postsynaptic damage and microglial activation in AD could be shown using all these genes. Further confirmations are needed to demonstrate the close link between these genes." @default.
• W3087333470 created "2020-09-25" @default.
• W3087333470 creator A5040810294 @default.
• W3087333470 creator A5044330424 @default.
• W3087333470 creator A5044548344 @default.
• W3087333470 creator A5058992754 @default.
• W3087333470 creator A5065671807 @default.
• W3087333470 date "2020-12-01" @default.
• W3087333470 modified "2023-10-02" @default.
• W3087333470 title "Postsynaptic damage and microglial activation in AD patients could be linked CXCR4/CXCL12 expression levels" @default.
• W3087333470 cites W129677802 @default.
• W3087333470 cites W1585095351 @default.
• W3087333470 cites W1757839782 @default.
• W3087333470 cites W1909967580 @default.
• W3087333470 cites W1977163745 @default.
• W3087333470 cites W1982024899 @default.
• W3087333470 cites W1994254814 @default.
• W3087333470 cites W1995403392 @default.
• W3087333470 cites W1995479601 @default.
• W3087333470 cites W1997838879 @default.
• W3087333470 cites W2000189134 @default.
• W3087333470 cites W2002264579 @default.
• W3087333470 cites W2004856335 @default.
• W3087333470 cites W2022689242 @default.
• W3087333470 cites W2027764072 @default.
• W3087333470 cites W2027793359 @default.
• W3087333470 cites W2028038884 @default.
• W3087333470 cites W2032940358 @default.
• W3087333470 cites W2033105784 @default.
• W3087333470 cites W2035314135 @default.
• W3087333470 cites W2043605366 @default.
• W3087333470 cites W2047770330 @default.
• W3087333470 cites W2049554950 @default.
• W3087333470 cites W2060845434 @default.
• W3087333470 cites W2061116800 @default.
• W3087333470 cites W2061859660 @default.
• W3087333470 cites W2063486268 @default.
• W3087333470 cites W2065020285 @default.
• W3087333470 cites W2069230139 @default.
• W3087333470 cites W2076686768 @default.
• W3087333470 cites W2081098333 @default.
• W3087333470 cites W2082402714 @default.
• W3087333470 cites W2087243986 @default.
• W3087333470 cites W2089337215 @default.
• W3087333470 cites W2093352510 @default.
• W3087333470 cites W2101970362 @default.
• W3087333470 cites W2103428562 @default.
• W3087333470 cites W2110626362 @default.
• W3087333470 cites W2110670805 @default.
• W3087333470 cites W2110774263 @default.
• W3087333470 cites W2110940238 @default.
• W3087333470 cites W2111219940 @default.
• W3087333470 cites W2114926230 @default.
• W3087333470 cites W2118641334 @default.
• W3087333470 cites W2123035720 @default.
• W3087333470 cites W2124373444 @default.
• W3087333470 cites W2130424304 @default.
• W3087333470 cites W2131055149 @default.
• W3087333470 cites W2135202855 @default.
• W3087333470 cites W21428969 @default.
• W3087333470 cites W2146026944 @default.
• W3087333470 cites W2150730731 @default.
• W3087333470 cites W2158695205 @default.
• W3087333470 cites W2159019462 @default.
• W3087333470 cites W2162997750 @default.
• W3087333470 cites W2164358671 @default.
• W3087333470 cites W2165739257 @default.
• W3087333470 cites W2168223153 @default.
• W3087333470 cites W2191098263 @default.
• W3087333470 cites W2205370315 @default.
• W3087333470 cites W2205427262 @default.
• W3087333470 cites W2257675936 @default.
• W3087333470 cites W2282411550 @default.
• W3087333470 cites W2295844066 @default.
• W3087333470 cites W2399298158 @default.
• W3087333470 cites W2431321293 @default.
• W3087333470 cites W2516406792 @default.
• W3087333470 cites W2531181314 @default.
• W3087333470 cites W2542882196 @default.
• W3087333470 cites W2606083510 @default.
• W3087333470 cites W2612324143 @default.
• W3087333470 cites W2617133757 @default.
• W3087333470 cites W2751938466 @default.
• W3087333470 cites W2754277804 @default.
• W3087333470 cites W2761360634 @default.
• W3087333470 cites W2776135473 @default.
• W3087333470 cites W2782731988 @default.
• W3087333470 cites W2788003845 @default.
• W3087333470 cites W2803197343 @default.
• W3087333470 cites W2888690268 @default.
• W3087333470 cites W2894963806 @default.
• W3087333470 cites W2903624772 @default.
• W3087333470 cites W2904483712 @default.
• W3087333470 cites W2905428026 @default.
• W3087333470 cites W2916084733 @default.
• W3087333470 cites W2921425544 @default.
• W3087333470 cites W2946291103 @default.
• W3087333470 cites W2950176133 @default.

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