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• W3087335736 abstract "Aim: To evaluate changes in health-related quality of life (HRQoL) in a Phase II trial (NCT02155647) of treatment-naive patients with metastatic Merkel cell carcinoma treated with avelumab (15-month follow-up). Materials & methods: Mixed-effect Models for Repeated Measures were applied to HRQoL data (FACT-M; EQ-5D-5L) to assess changes over time. Clinically derived progression-free survival was compared with HRQoL deterioration-free survival. Results: Overall, we saw relative stability in HRQoL among 116 included patients, with nonprogression associated with statistically and clinically meaningful better HRQoL compared with progressive disease. Deterioration-free survival rates (49–72% at 6 months, 40–58% at 12 months) were consistently higher/better compared with progression-free survival rates (41/31% at 6/12 months). Conclusion: These findings show unique longitudinal HRQoL data for treatment-naive metastatic Merkel cell carcinoma patients treated with avelumab. Clinical trial registration: NCT02155647 ( ClinicalTrials.gov )." @default.
• W3087335736 created "2020-09-25" @default.
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• W3087335736 date "2020-09-01" @default.
• W3087335736 modified "2023-10-17" @default.
• W3087335736 title "Health-related quality of life trajectory of treatment-naive patients with Merkel cell carcinoma receiving avelumab" @default.
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• W3087335736 doi "https://doi.org/10.2217/fon-2020-0426" @default.
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