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• W3087350907 startingPage "1384" @default.
• W3087350907 abstract "Hematopoiesis has long served as a paradigm of stem cell biology and tissue homeostasis. In the past decade, the genomics revolution has ushered in powerful new methods for investigating the hematopoietic system that have provided transformative insights into its biology. As part of the advances in genomics, increasingly accurate deep sequencing and novel methods of cell tracking have revealed hematopoiesis to be more of a continuous and less of a discrete and punctuated process than originally envisioned. In part, this continuous nature of hematopoiesis is made possible by the emergent outcomes of vast, interconnected regulatory networks that influence cell fates and lineage commitment. It is also becoming clear how these mechanisms are modulated by genetic variation present throughout the population. This review describes how these recently uncovered complexities are reshaping our concept of tissue development and homeostasis while opening up a more comprehensive future understanding of hematopoiesis." @default.
• W3087350907 created "2020-09-25" @default.
• W3087350907 creator A5040881212 @default.
• W3087350907 creator A5077513980 @default.
• W3087350907 date "2020-09-01" @default.
• W3087350907 modified "2023-10-16" @default.
• W3087350907 title "Unraveling Hematopoiesis through the Lens of Genomics" @default.
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