Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087365499> ?p ?o ?g. }
- W3087365499 endingPage "719" @default.
- W3087365499 startingPage "706" @default.
- W3087365499 abstract "Abstract Drug delivery to the brain is greatly hampered by the presence of the blood–brain barrier (BBB) which tightly regulates the passage of molecules from blood to brain and vice versa. Nanocarriers, in which drugs can be encapsulated, can move across the blood–brain barrier (BBB) via the process of transcytosis, thus showing promise to improve drug delivery to the brain. Here, we demonstrate the use of natural nanovesicles, that is, exosomes, derived from C17.2 neural stem cells (NSCs) to efficiently carry a protein cargo across an in vitro BBB model consisting of human brain microvascular endothelial cells. We show that the exosomes are primarily taken up in brain endothelial cells via endocytosis, while heparan sulfate proteoglycans (HSPGs) act as receptors. Taken together, our data support the view that NSC exosomes may act as biological nanocarriers for efficient passage across the BBB. Nanomedicines that target HSPGs may improve their binding to brain endothelial cells and, possibly, show subsequent transcytosis across the BBB." @default.
- W3087365499 created "2020-09-25" @default.
- W3087365499 creator A5072623600 @default.
- W3087365499 creator A5081167730 @default.
- W3087365499 date "2020-09-30" @default.
- W3087365499 modified "2023-10-07" @default.
- W3087365499 title "Heparan sulfate proteoglycan‐mediated dynamin‐dependent transport of neural stem cell exosomes in an in vitro blood–brain barrier model" @default.
- W3087365499 cites W1721689174 @default.
- W3087365499 cites W1762620449 @default.
- W3087365499 cites W1950118853 @default.
- W3087365499 cites W1965149143 @default.
- W3087365499 cites W1975279212 @default.
- W3087365499 cites W1987002621 @default.
- W3087365499 cites W1987598198 @default.
- W3087365499 cites W1993337563 @default.
- W3087365499 cites W1995037165 @default.
- W3087365499 cites W1995968681 @default.
- W3087365499 cites W2008627178 @default.
- W3087365499 cites W2014851261 @default.
- W3087365499 cites W2022412433 @default.
- W3087365499 cites W2033467450 @default.
- W3087365499 cites W2040692189 @default.
- W3087365499 cites W2043752993 @default.
- W3087365499 cites W2045188517 @default.
- W3087365499 cites W2051054916 @default.
- W3087365499 cites W2059979504 @default.
- W3087365499 cites W2063793616 @default.
- W3087365499 cites W2065566358 @default.
- W3087365499 cites W2066234893 @default.
- W3087365499 cites W2071625709 @default.
- W3087365499 cites W2086704388 @default.
- W3087365499 cites W2091250479 @default.
- W3087365499 cites W2092841320 @default.
- W3087365499 cites W2094392013 @default.
- W3087365499 cites W2098240454 @default.
- W3087365499 cites W2098259366 @default.
- W3087365499 cites W2105251923 @default.
- W3087365499 cites W2106081613 @default.
- W3087365499 cites W2106843179 @default.
- W3087365499 cites W2107065228 @default.
- W3087365499 cites W2112032807 @default.
- W3087365499 cites W2113972541 @default.
- W3087365499 cites W2116566546 @default.
- W3087365499 cites W2117696215 @default.
- W3087365499 cites W2119195037 @default.
- W3087365499 cites W2122372853 @default.
- W3087365499 cites W2124518520 @default.
- W3087365499 cites W2130929362 @default.
- W3087365499 cites W2131334695 @default.
- W3087365499 cites W2138037217 @default.
- W3087365499 cites W2148278891 @default.
- W3087365499 cites W2148921071 @default.
- W3087365499 cites W2150561062 @default.
- W3087365499 cites W2151132500 @default.
- W3087365499 cites W2152821878 @default.
- W3087365499 cites W2156805103 @default.
- W3087365499 cites W2167279371 @default.
- W3087365499 cites W2168120562 @default.
- W3087365499 cites W2181047666 @default.
- W3087365499 cites W2253028130 @default.
- W3087365499 cites W2295603197 @default.
- W3087365499 cites W2324589358 @default.
- W3087365499 cites W2418046184 @default.
- W3087365499 cites W2419179834 @default.
- W3087365499 cites W2527689752 @default.
- W3087365499 cites W2552099798 @default.
- W3087365499 cites W2592633538 @default.
- W3087365499 cites W2600094664 @default.
- W3087365499 cites W2736233594 @default.
- W3087365499 cites W2751476134 @default.
- W3087365499 cites W2754129305 @default.
- W3087365499 cites W2761038569 @default.
- W3087365499 cites W2783974359 @default.
- W3087365499 cites W2792837771 @default.
- W3087365499 cites W2795868806 @default.
- W3087365499 cites W2893799637 @default.
- W3087365499 cites W2896357540 @default.
- W3087365499 cites W2896954918 @default.
- W3087365499 cites W2897132139 @default.
- W3087365499 cites W2946630278 @default.
- W3087365499 cites W3036596408 @default.
- W3087365499 doi "https://doi.org/10.1111/ejn.14974" @default.
- W3087365499 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7891616" @default.
- W3087365499 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32939863" @default.
- W3087365499 hasPublicationYear "2020" @default.
- W3087365499 type Work @default.
- W3087365499 sameAs 3087365499 @default.
- W3087365499 citedByCount "26" @default.
- W3087365499 countsByYear W30873654992020 @default.
- W3087365499 countsByYear W30873654992021 @default.
- W3087365499 countsByYear W30873654992022 @default.
- W3087365499 countsByYear W30873654992023 @default.
- W3087365499 crossrefType "journal-article" @default.
- W3087365499 hasAuthorship W3087365499A5072623600 @default.
- W3087365499 hasAuthorship W3087365499A5081167730 @default.
- W3087365499 hasBestOaLocation W30873654991 @default.
- W3087365499 hasConcept C104317684 @default.
- W3087365499 hasConcept C123012128 @default.