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• W3087377834 endingPage "2000612" @default.
• W3087377834 startingPage "2000612" @default.
• W3087377834 abstract "Background Obesity is a common comorbidity in asthma and associated with poorer asthma control, more frequent/severe exacerbations, and reduced response to asthma pharmacotherapy. Objective This review aims to compare use of all classes of asthma medications in obese (body mass index (BMI) ≤30 kg·m −2 ) versus healthy-weight (BMI <25 kg·m −2 ) subjects with asthma. Design Databases including CINAHL (Cumulative Index to Nursing and Allied Health Literature), Cochrane, Embase and MEDLINE were searched up to July 2019 for English-language studies that recorded medication use or dose in obese and healthy-weight adults with asthma. A critical appraisal checklist was utilised for scrutinising methodological quality of eligible studies. Meta-analysis was performed and heterogeneity was examined with the use of the Chi-squared test. This review was conducted based on a published protocol ( www.crd.york.ac.uk/PROSPERO CRD42020148671). Results Meta-analysis showed that obese subjects are more likely to use asthma medications, including short-acting β 2 -agonists (OR 1.75, 95% CI 1.17–2.60; p=0.006, I 2 =41%) and maintenance oral corticosteroids (OR 1.86, 95% CI 1.49–2.31; p<0.001, I 2 =0%) compared to healthy-weight subjects. Inhaled corticosteroid (ICS) dose (µg·day −1 ) was significantly higher in obese subjects (mean difference 208.14, 95% CI 107.01–309.27; p<0.001, I 2 =74%). Forced expiratory volume in 1 s (FEV 1 ) % predicted was significantly lower in obese subjects (mean difference −5.32%, 95% CI −6.75–−3.89; p<0.001, I 2 =42%); however, no significant differences were observed in FEV 1 /forced vital capacity (FVC) ratio between groups. Conclusions We found that obese subjects with asthma have higher use of all included asthma medication classes and higher ICS doses than healthy-weight asthma subjects, despite lower FEV 1 and a similar FEV 1 /FVC %. A better understanding of the factors driving increased medication use is required to improve outcomes in this subgroup of asthmatics." @default.
• W3087377834 created "2020-09-25" @default.
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• W3087377834 date "2020-09-17" @default.
• W3087377834 modified "2023-10-16" @default.
• W3087377834 title "Asthma medication use in obese and healthy weight asthma: systematic review/meta-analysis" @default.
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• W3087377834 doi "https://doi.org/10.1183/13993003.00612-2020" @default.
• W3087377834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32943399" @default.
• W3087377834 hasPublicationYear "2020" @default.
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