Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087396357> ?p ?o ?g. }
- W3087396357 endingPage "173575" @default.
- W3087396357 startingPage "173575" @default.
- W3087396357 abstract "MS-275 (Entinostat), is an oral histone deacetylase (HDAC) inhibitor with a high specificity for class 1 HDACs. As single agent, MS-275 exerts only modest antitumor activity against most solid malignancies. The use of MS-275 in combination with other anticancer agents is currently being evaluated to determine whether this approach can achieve superior therapeutic efficacy. Tetrandrine, a bisbenzylisoquinoline alkaloid isolated from the root of a Chinese medicinal herb, is safe and exhibits low toxicity, showing great potential to enhance chemotherapeutic efficacy. In the present study, we investigated the synergistic antitumor effects of MS-275 in combination with tetrandrine. Based on the results of in vitro experiments, the application of MS-275 in combination with tetrandrine induced selective apoptotic death in various cancer cells but spared normal cells. Mechanistically, the combination treatment induced a dramatic accumulation of reactive oxygen species (ROS), and a pretreatment with the ROS scavenger N-acetyl-L-cysteine (NAC) significantly prevented the cellular apoptosis induced by MS-275/tetrandrine. Moreover, molecular assays indicated that Bax and p53 were the key regulators of MS-275/tetrandrine induced apoptosis. The results of the in vivo studies were consistent with the results of the in vitro studies. Based on our findings, tetrandrine enhanced the antitumor effects of MS-275 in a Bax- and p53-dependent manner. The combination of MS-275 and tetrandrine may represent a novel and promising therapeutic strategy for cancer." @default.
- W3087396357 created "2020-09-25" @default.
- W3087396357 creator A5001162052 @default.
- W3087396357 creator A5019137664 @default.
- W3087396357 creator A5061780047 @default.
- W3087396357 creator A5076476786 @default.
- W3087396357 creator A5087316133 @default.
- W3087396357 date "2020-12-01" @default.
- W3087396357 modified "2023-10-18" @default.
- W3087396357 title "Tetrandrine enhances antitumor effects of the histone deacetylase inhibitor MS-275 in human cancer in a Bax- and p53-dependent manner" @default.
- W3087396357 cites W1969524738 @default.
- W3087396357 cites W1972779889 @default.
- W3087396357 cites W1980385765 @default.
- W3087396357 cites W1983315005 @default.
- W3087396357 cites W1984547206 @default.
- W3087396357 cites W2002697622 @default.
- W3087396357 cites W2004952299 @default.
- W3087396357 cites W2006483529 @default.
- W3087396357 cites W2011761515 @default.
- W3087396357 cites W2023623233 @default.
- W3087396357 cites W2028897202 @default.
- W3087396357 cites W2041511542 @default.
- W3087396357 cites W2046091686 @default.
- W3087396357 cites W2058260807 @default.
- W3087396357 cites W2078500792 @default.
- W3087396357 cites W2092145777 @default.
- W3087396357 cites W2095160131 @default.
- W3087396357 cites W2100596948 @default.
- W3087396357 cites W2112725925 @default.
- W3087396357 cites W2114882308 @default.
- W3087396357 cites W2117692326 @default.
- W3087396357 cites W2128837905 @default.
- W3087396357 cites W2130027352 @default.
- W3087396357 cites W2160641961 @default.
- W3087396357 cites W2165635928 @default.
- W3087396357 cites W2167888501 @default.
- W3087396357 cites W2175728132 @default.
- W3087396357 cites W2289284908 @default.
- W3087396357 cites W2342868230 @default.
- W3087396357 cites W2414880314 @default.
- W3087396357 cites W2519953954 @default.
- W3087396357 cites W2548196609 @default.
- W3087396357 cites W2559943287 @default.
- W3087396357 cites W2752942423 @default.
- W3087396357 cites W2772062014 @default.
- W3087396357 cites W2791440475 @default.
- W3087396357 cites W2793489332 @default.
- W3087396357 cites W2794545404 @default.
- W3087396357 cites W2800239190 @default.
- W3087396357 cites W2805978257 @default.
- W3087396357 cites W2809641034 @default.
- W3087396357 cites W2810106181 @default.
- W3087396357 doi "https://doi.org/10.1016/j.ejphar.2020.173575" @default.
- W3087396357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32950498" @default.
- W3087396357 hasPublicationYear "2020" @default.
- W3087396357 type Work @default.
- W3087396357 sameAs 3087396357 @default.
- W3087396357 citedByCount "2" @default.
- W3087396357 countsByYear W30873963572022 @default.
- W3087396357 countsByYear W30873963572023 @default.
- W3087396357 crossrefType "journal-article" @default.
- W3087396357 hasAuthorship W3087396357A5001162052 @default.
- W3087396357 hasAuthorship W3087396357A5019137664 @default.
- W3087396357 hasAuthorship W3087396357A5061780047 @default.
- W3087396357 hasAuthorship W3087396357A5076476786 @default.
- W3087396357 hasAuthorship W3087396357A5087316133 @default.
- W3087396357 hasConcept C104317684 @default.
- W3087396357 hasConcept C121608353 @default.
- W3087396357 hasConcept C150903083 @default.
- W3087396357 hasConcept C185592680 @default.
- W3087396357 hasConcept C190283241 @default.
- W3087396357 hasConcept C202751555 @default.
- W3087396357 hasConcept C207001950 @default.
- W3087396357 hasConcept C2776202225 @default.
- W3087396357 hasConcept C2778305200 @default.
- W3087396357 hasConcept C2779934757 @default.
- W3087396357 hasConcept C48349386 @default.
- W3087396357 hasConcept C502942594 @default.
- W3087396357 hasConcept C54355233 @default.
- W3087396357 hasConcept C55493867 @default.
- W3087396357 hasConcept C64927066 @default.
- W3087396357 hasConcept C86803240 @default.
- W3087396357 hasConcept C96232424 @default.
- W3087396357 hasConcept C98274493 @default.
- W3087396357 hasConceptScore W3087396357C104317684 @default.
- W3087396357 hasConceptScore W3087396357C121608353 @default.
- W3087396357 hasConceptScore W3087396357C150903083 @default.
- W3087396357 hasConceptScore W3087396357C185592680 @default.
- W3087396357 hasConceptScore W3087396357C190283241 @default.
- W3087396357 hasConceptScore W3087396357C202751555 @default.
- W3087396357 hasConceptScore W3087396357C207001950 @default.
- W3087396357 hasConceptScore W3087396357C2776202225 @default.
- W3087396357 hasConceptScore W3087396357C2778305200 @default.
- W3087396357 hasConceptScore W3087396357C2779934757 @default.
- W3087396357 hasConceptScore W3087396357C48349386 @default.
- W3087396357 hasConceptScore W3087396357C502942594 @default.
- W3087396357 hasConceptScore W3087396357C54355233 @default.
- W3087396357 hasConceptScore W3087396357C55493867 @default.