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• W3087396515 endingPage "110487" @default.
• W3087396515 startingPage "110487" @default.
• W3087396515 abstract "The surface shape is an important aspect to take into account to ensure the success of an implant. At the cellular scale level, the cell behaviour, especially its migration, is affected by the specificities of the surface of the substrate, such as the stiffness of the surface and its roughness topography. The latter has been shown to have a great impact on various cell mechanisms, such as the cell adhesion, migration, or proliferation. In fact, the mere presence of micro roughness leads to an improvement of those mechanisms, with a better integration of the implants. However, the phenomena behind those improvements are still not clear. In this paper, we propose a three-dimensional (3D) model of a single cell migration using a Cellular Potts (CP) model to study the influence of the surface topography on cell motility. To do so, various configurations were tested, such as: (i) a substrate with a random roughness, (ii) a substrate with a rectangular groove pattern (parallel and perpendicular to the direction of motion), (ii) a substrate with a sinusoidal groove pattern. To evaluate the influence of the surface topography on cell motility, for each configuration, the cell speed and shape as well as the contact surface between the cell and the substrate have been quantified. Our numerical results demonstrate that, in agreement with the experimental observations of the literature, the substrate topography has an influence on the cell efficiency (i.e. cell speed), orientation and shape. Besides, we also show that the increase of the contact surface alone in presence of roughness is not enough to explain the improvement of cell migration on the various rough surfaces. Finally, we highlight the importance of the roughness dimension on cell motility. This could be a critical aspect to consider for further analyses and applications, such as surface treatments for medical applications." @default.
• W3087396515 created "2020-09-25" @default.
• W3087396515 creator A5013422239 @default.
• W3087396515 creator A5031133310 @default.
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• W3087396515 date "2021-01-01" @default.
• W3087396515 modified "2023-09-30" @default.
• W3087396515 title "A Cellular Potts energy-based approach to analyse the influence of the surface topography on single cell motility" @default.
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• W3087396515 doi "https://doi.org/10.1016/j.jtbi.2020.110487" @default.
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• W3087396515 hasPublicationYear "2021" @default.
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