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- W3087454025 abstract "Significance Conclusive identification of single genes contributing to complex autoimmune diseases has been challenging. Here, we positionally identify the vitamin D3 receptor gene ( Vdr ) as a driver of T cell-dependent inflammatory diseases using forward genetics. In the process, we generated congenic mice that overexpress Vdr in T cells as a consequence of natural polymorphisms in its promoter. These mice present a unique opportunity to study the immunomodulatory properties of VDR in a physiological setting. Moreover, the restricted overexpression of VDR to immune cells allows discrimination between immune-acting and confounding musculoskeletal effects of VDR. Our results suggest that VDR plays a role in T cell activation in parallel to the antiinflammatory actions mediated by its ligand." @default.
- W3087454025 created "2020-09-25" @default.
- W3087454025 creator A5010629312 @default.
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- W3087454025 creator A5091032474 @default.
- W3087454025 date "2020-09-21" @default.
- W3087454025 modified "2023-10-03" @default.
- W3087454025 title "Vitamin D3 receptor polymorphisms regulate T cells and T cell-dependent inflammatory diseases" @default.
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