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• W3087473460 abstract "Sepsis is not a monolithic disease, but a loose collection of symptoms with diverse outcomes. Thus, stratification and subtyping of sepsis patients is of great importance. We examine the temporal evolution of patient state using our previously-published method for computing risk of transition from sepsis into septic shock. Risk trajectories diverge into four clusters following early prediction of septic shock, stratifying by outcome: the highest-risk and lowest-risk groups have a 76.5% and 10.4% prevalence of septic shock, and 43% and 18% mortality, respectively. These clusters differ also in treatments received and median time to shock onset. Analyses reveal the existence of a rapid (30–60 min) transition in risk at the time of threshold crossing. We hypothesize that this transition occurs as a result of the failure of compensatory biological systems to cope with infection, resulting in a bifurcation of low to high risk. Such a collapse, we believe, represents the true onset of septic shock. Thus, this rapid elevation in risk represents a potential new data-driven definition of septic shock." @default.
• W3087473460 created "2020-09-25" @default.
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• W3087473460 date "2020-09-22" @default.
• W3087473460 modified "2023-10-14" @default.
• W3087473460 title "Spectral clustering of risk score trajectories stratifies sepsis patients by clinical outcome and interventions received" @default.
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• W3087473460 doi "https://doi.org/10.7554/elife.58142" @default.
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