Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087483314> ?p ?o ?g. }
- W3087483314 endingPage "10661" @default.
- W3087483314 startingPage "10648" @default.
- W3087483314 abstract "Abstract Cells rely on stress response pathways to uphold cellular homeostasis and limit the negative effects of harmful environmental stimuli. The stress- and mitogen-activated protein (MAP) kinases, p38 and JNK, are at the nexus of numerous stress responses, among these the ribotoxic stress response (RSR). Ribosomal impairment is detrimental to cell function as it disrupts protein synthesis, increase inflammatory signaling and, if unresolved, lead to cell death. In this review, we offer a general overview of the three main translation surveillance pathways; the RSR, Ribosome-associated Quality Control (RQC) and the Integrated Stress Response (ISR). We highlight recent advances made in defining activation mechanisms for these pathways and discuss their commonalities and differences. Finally, we reflect on the physiological role of the RSR and consider the therapeutic potential of targeting the sensing kinase ZAKα for treatment of ribotoxin exposure." @default.
- W3087483314 created "2020-09-25" @default.
- W3087483314 creator A5056486750 @default.
- W3087483314 creator A5061629751 @default.
- W3087483314 creator A5063029794 @default.
- W3087483314 date "2020-09-17" @default.
- W3087483314 modified "2023-10-16" @default.
- W3087483314 title "Ribosomal stress-surveillance: three pathways is a magic number" @default.
- W3087483314 cites W1530284699 @default.
- W3087483314 cites W1534382357 @default.
- W3087483314 cites W1547803736 @default.
- W3087483314 cites W1572174728 @default.
- W3087483314 cites W1751748906 @default.
- W3087483314 cites W1816379352 @default.
- W3087483314 cites W1964289196 @default.
- W3087483314 cites W1964785626 @default.
- W3087483314 cites W1965909642 @default.
- W3087483314 cites W1969830421 @default.
- W3087483314 cites W1970195253 @default.
- W3087483314 cites W1970480600 @default.
- W3087483314 cites W1973750030 @default.
- W3087483314 cites W1975974673 @default.
- W3087483314 cites W1977188969 @default.
- W3087483314 cites W1980272041 @default.
- W3087483314 cites W1982499214 @default.
- W3087483314 cites W1983859619 @default.
- W3087483314 cites W1984253264 @default.
- W3087483314 cites W1984903682 @default.
- W3087483314 cites W1985387528 @default.
- W3087483314 cites W1987185222 @default.
- W3087483314 cites W1989768108 @default.
- W3087483314 cites W1992657741 @default.
- W3087483314 cites W1995806196 @default.
- W3087483314 cites W1998487776 @default.
- W3087483314 cites W2000789682 @default.
- W3087483314 cites W2004143904 @default.
- W3087483314 cites W2005293659 @default.
- W3087483314 cites W2012072673 @default.
- W3087483314 cites W2013779315 @default.
- W3087483314 cites W2014194720 @default.
- W3087483314 cites W2014423141 @default.
- W3087483314 cites W2015730823 @default.
- W3087483314 cites W2020589362 @default.
- W3087483314 cites W2020675675 @default.
- W3087483314 cites W2020938653 @default.
- W3087483314 cites W2023831963 @default.
- W3087483314 cites W2028238593 @default.
- W3087483314 cites W2030900078 @default.
- W3087483314 cites W2032731042 @default.
- W3087483314 cites W2033320490 @default.
- W3087483314 cites W2035967893 @default.
- W3087483314 cites W2037786814 @default.
- W3087483314 cites W2037915962 @default.
- W3087483314 cites W2038291983 @default.
- W3087483314 cites W2044353042 @default.
- W3087483314 cites W2048012950 @default.
- W3087483314 cites W2048112210 @default.
- W3087483314 cites W2048551040 @default.
- W3087483314 cites W2048625405 @default.
- W3087483314 cites W2054586162 @default.
- W3087483314 cites W2058571520 @default.
- W3087483314 cites W2060618287 @default.
- W3087483314 cites W2062717825 @default.
- W3087483314 cites W2063208932 @default.
- W3087483314 cites W2068383544 @default.
- W3087483314 cites W2070330987 @default.
- W3087483314 cites W2071534068 @default.
- W3087483314 cites W2071849521 @default.
- W3087483314 cites W2076902656 @default.
- W3087483314 cites W2077880395 @default.
- W3087483314 cites W2078065785 @default.
- W3087483314 cites W2079308917 @default.
- W3087483314 cites W2079619202 @default.
- W3087483314 cites W2079749507 @default.
- W3087483314 cites W2082145206 @default.
- W3087483314 cites W2084472730 @default.
- W3087483314 cites W2086855617 @default.
- W3087483314 cites W2092013543 @default.
- W3087483314 cites W2095859714 @default.
- W3087483314 cites W2101525705 @default.
- W3087483314 cites W2104896634 @default.
- W3087483314 cites W2105015603 @default.
- W3087483314 cites W2107495112 @default.
- W3087483314 cites W2112967018 @default.
- W3087483314 cites W2114108194 @default.
- W3087483314 cites W2114111268 @default.
- W3087483314 cites W2116254970 @default.
- W3087483314 cites W2116669532 @default.
- W3087483314 cites W2118188078 @default.
- W3087483314 cites W2122033270 @default.
- W3087483314 cites W2122500419 @default.
- W3087483314 cites W2129532016 @default.
- W3087483314 cites W2130934136 @default.
- W3087483314 cites W2131632095 @default.
- W3087483314 cites W2136024858 @default.
- W3087483314 cites W2139139966 @default.
- W3087483314 cites W2140170107 @default.
- W3087483314 cites W2140796894 @default.