Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087518312> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W3087518312 endingPage "1201" @default.
- W3087518312 startingPage "1195" @default.
- W3087518312 abstract "Polypharmacy poses risks associated with drug-drug interactions, increased adverse effects, pill burden, poor compliance and unfavorable treatment outcomes. Whether polypharmacy affects treatment outcomes among people living with HIV (PLHIV) is largely unknown. A prospective study was conducted among PLHIV followed-up at a tertiary-care clinic of an academic medical center during January 2012 to December 2017. The clinic provided comprehensive HIV care with multidisciplinary team approach focusing on treatment adherence. Polypharmacy was defined as concurrent use of 5 or more non-antiretroviral (ARV) drugs for at least one year. Of the 248 PLHIV included, 23 (9%) received polypharmacy. PLHIV with polypharmacy were older (median age 45 vs. 36 years), were more likely to have underlying diseases (65% vs. 18%) and had lower median initial CD4 counts (40 vs. 214 cells/mm 3 ). The rates of virologic suppression at 12 months after ARV therapy were 96% and 92% in polypharmacy and non-polypharmacy groups, respectively (P = 0.70), while the median CD4 cell count increase was higher among the non-polypharmacy group at 12 months (207 vs. 403 cells/mm 3 ; P < 0.001). There were no differences in rates of adverse effects and experienced drug-drug interactions. Hospitalization due to HIV-related diseases within 12 months after ARV initiation [adjusted odds ratio (aOR) 11.63, P = 0.004] and lower 3-item score for ARV adherence (aOR 0.49, P = 0.01) were independently associated with failure of virologic suppression at 12 months. These findings suggest that polypharmacy did not affect the virological outcomes among our PLHIV. Patients with the characteristics associated with virological failure should be closely monitored." @default.
- W3087518312 created "2020-09-25" @default.
- W3087518312 creator A5076729437 @default.
- W3087518312 creator A5091719582 @default.
- W3087518312 date "2020-09-14" @default.
- W3087518312 modified "2023-09-23" @default.
- W3087518312 title "Does polypharmacy affect treatment outcomes of people living with HIV starting antiretroviral therapy?" @default.
- W3087518312 cites W1963867953 @default.
- W3087518312 cites W1968241317 @default.
- W3087518312 cites W2040185843 @default.
- W3087518312 cites W2112289092 @default.
- W3087518312 cites W2791013669 @default.
- W3087518312 cites W2969787155 @default.
- W3087518312 cites W3008667093 @default.
- W3087518312 cites W3021216415 @default.
- W3087518312 doi "https://doi.org/10.1177/0956462420949798" @default.
- W3087518312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32928055" @default.
- W3087518312 hasPublicationYear "2020" @default.
- W3087518312 type Work @default.
- W3087518312 sameAs 3087518312 @default.
- W3087518312 citedByCount "4" @default.
- W3087518312 countsByYear W30875183122023 @default.
- W3087518312 crossrefType "journal-article" @default.
- W3087518312 hasAuthorship W3087518312A5076729437 @default.
- W3087518312 hasAuthorship W3087518312A5091719582 @default.
- W3087518312 hasConcept C126322002 @default.
- W3087518312 hasConcept C138885662 @default.
- W3087518312 hasConcept C156957248 @default.
- W3087518312 hasConcept C197934379 @default.
- W3087518312 hasConcept C2776035688 @default.
- W3087518312 hasConcept C36434225 @default.
- W3087518312 hasConcept C41895202 @default.
- W3087518312 hasConcept C71924100 @default.
- W3087518312 hasConcept C81603835 @default.
- W3087518312 hasConcept C98274493 @default.
- W3087518312 hasConceptScore W3087518312C126322002 @default.
- W3087518312 hasConceptScore W3087518312C138885662 @default.
- W3087518312 hasConceptScore W3087518312C156957248 @default.
- W3087518312 hasConceptScore W3087518312C197934379 @default.
- W3087518312 hasConceptScore W3087518312C2776035688 @default.
- W3087518312 hasConceptScore W3087518312C36434225 @default.
- W3087518312 hasConceptScore W3087518312C41895202 @default.
- W3087518312 hasConceptScore W3087518312C71924100 @default.
- W3087518312 hasConceptScore W3087518312C81603835 @default.
- W3087518312 hasConceptScore W3087518312C98274493 @default.
- W3087518312 hasIssue "12" @default.
- W3087518312 hasLocation W30875183121 @default.
- W3087518312 hasOpenAccess W3087518312 @default.
- W3087518312 hasPrimaryLocation W30875183121 @default.
- W3087518312 hasRelatedWork W1993876728 @default.
- W3087518312 hasRelatedWork W2064322231 @default.
- W3087518312 hasRelatedWork W2112289092 @default.
- W3087518312 hasRelatedWork W2360070380 @default.
- W3087518312 hasRelatedWork W2590324011 @default.
- W3087518312 hasRelatedWork W2766670173 @default.
- W3087518312 hasRelatedWork W3094466850 @default.
- W3087518312 hasRelatedWork W4238528222 @default.
- W3087518312 hasRelatedWork W4378549226 @default.
- W3087518312 hasRelatedWork W2955764874 @default.
- W3087518312 hasVolume "31" @default.
- W3087518312 isParatext "false" @default.
- W3087518312 isRetracted "false" @default.
- W3087518312 magId "3087518312" @default.
- W3087518312 workType "article" @default.