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• W3087520133 abstract "Milking speed (MS) and temperament (MT) are 2 workability traits of great importance in dairy cattle production and breeding. This is mainly due to an increased intensification of the worldwide production systems and greater adoption of precision technologies with less human-cattle interaction. Both MS and MT are heritable traits and thus, genomic selection is a promising tool to expedite their genetic progress. However, the genetic architecture and biological mechanisms underlying the phenotypic expression of these traits remain underexplored. In this study, we investigated the association of >5.7 million imputed whole-genome sequence variants with MT and MS in 4,381 and 4,219 North American Holstein cattle, respectively. The statistical analyses were performed using a mixed linear model fitting a polygenic effect. We detected 40 and 35 significant SNPs independently associated with MT and MS, respectively, which were distributed across 26 chromosomes. Eight candidate genes (GRIN3A, KCNJ3, BOSTAUV1R417, BOSTAUV1R419, MAP2K5, KCTD3, GAP43, and LSAMP) were suggested to play an important role in MT as they are involved in biologically relevant pathways, such as glutamatergic synapse, vomeronasal receptor and oxytocin signaling. Within their coding and upstream sequences, we used an independent data set to further detect or validate significantly differentiated SNP between cattle breeds with known differences in MT. There were fewer candidate genes potentially implicated in MS, but immunity-related genes (e.g., BOLA-NC1 and LOC512672), also identified in other populations, were validated in this study. The significant SNP and novel candidate genes identified contribute to a better understanding of the biological mechanisms underlying both traits in dairy cattle. This information will also be useful for the optimization of prediction of genomic breeding values by giving greater weights to SNP located in the genomic regions identified." @default.
• W3087520133 created "2020-09-25" @default.
• W3087520133 creator A5015894671 @default.
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• W3087520133 creator A5057705536 @default.
• W3087520133 creator A5087146975 @default.
• W3087520133 date "2020-11-01" @default.
• W3087520133 modified "2023-09-27" @default.
• W3087520133 title "Using imputed whole-genome sequence variants to uncover candidate mutations and genes affecting milking speed and temperament in Holstein cattle" @default.
• W3087520133 cites W1607760198 @default.
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• W3087520133 cites W1963753281 @default.
• W3087520133 cites W1976958395 @default.
• W3087520133 cites W1982590641 @default.
• W3087520133 cites W1987724561 @default.
• W3087520133 cites W1988476404 @default.
• W3087520133 cites W1989969076 @default.
• W3087520133 cites W1995727920 @default.
• W3087520133 cites W2011904222 @default.
• W3087520133 cites W2012825954 @default.
• W3087520133 cites W2013247879 @default.
• W3087520133 cites W2013739323 @default.
• W3087520133 cites W2016451430 @default.
• W3087520133 cites W2018509395 @default.
• W3087520133 cites W2023158153 @default.
• W3087520133 cites W2027881175 @default.
• W3087520133 cites W2033151532 @default.
• W3087520133 cites W2040402447 @default.
• W3087520133 cites W2041545035 @default.
• W3087520133 cites W2048596365 @default.
• W3087520133 cites W2049370727 @default.
• W3087520133 cites W2053588621 @default.
• W3087520133 cites W2056058534 @default.
• W3087520133 cites W2058792575 @default.
• W3087520133 cites W2061661359 @default.
• W3087520133 cites W2079098929 @default.
• W3087520133 cites W2090075367 @default.
• W3087520133 cites W2102004744 @default.
• W3087520133 cites W2108183636 @default.
• W3087520133 cites W2110787179 @default.
• W3087520133 cites W2125439972 @default.
• W3087520133 cites W2125816301 @default.
• W3087520133 cites W2127209187 @default.
• W3087520133 cites W2128749543 @default.
• W3087520133 cites W2129605594 @default.
• W3087520133 cites W2131280774 @default.
• W3087520133 cites W2131968372 @default.
• W3087520133 cites W2158217645 @default.
• W3087520133 cites W2161633633 @default.
• W3087520133 cites W2164148960 @default.
• W3087520133 cites W2170621766 @default.
• W3087520133 cites W2171471617 @default.
• W3087520133 cites W2227733920 @default.
• W3087520133 cites W2511106168 @default.
• W3087520133 cites W2511378584 @default.
• W3087520133 cites W2567335054 @default.
• W3087520133 cites W2612591211 @default.
• W3087520133 cites W2725988230 @default.
• W3087520133 cites W2736745869 @default.
• W3087520133 cites W2737196618 @default.
• W3087520133 cites W2767206797 @default.
• W3087520133 cites W2767310212 @default.
• W3087520133 cites W2770094547 @default.
• W3087520133 cites W2778821701 @default.
• W3087520133 cites W2779918837 @default.
• W3087520133 cites W2784085354 @default.
• W3087520133 cites W2788939605 @default.
• W3087520133 cites W2794076441 @default.
• W3087520133 cites W2794694102 @default.
• W3087520133 cites W2800852647 @default.
• W3087520133 cites W2803750243 @default.
• W3087520133 cites W2807877716 @default.
• W3087520133 cites W2808328764 @default.
• W3087520133 cites W2808382008 @default.
• W3087520133 cites W2894166334 @default.
• W3087520133 cites W2899867539 @default.
• W3087520133 cites W2902196707 @default.
• W3087520133 cites W2921929133 @default.
• W3087520133 cites W2944363101 @default.
• W3087520133 cites W2949539428 @default.
• W3087520133 cites W2950644483 @default.
• W3087520133 cites W2952431387 @default.
• W3087520133 cites W3006406963 @default.
• W3087520133 cites W3008400109 @default.
• W3087520133 cites W3010769717 @default.
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• W3087520133 doi "https://doi.org/10.3168/jds.2020-18897" @default.
• W3087520133 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32952011" @default.
• W3087520133 hasPublicationYear "2020" @default.
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