Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087536359> ?p ?o ?g. }
- W3087536359 endingPage "3010" @default.
- W3087536359 startingPage "3010" @default.
- W3087536359 abstract "Basal cell carcinoma (BCC) is the most common malignant skin tumor. BCC displays a different behavior compared with other neoplasms, has a slow evolution, and metastasizes very rarely, but sometimes it causes an important local destruction. Chronic ultraviolet exposure along with genetic factors are the most important risk factors involved in BCC development. Mutations in the PTCH1 gene are associated with Gorlin syndrome, an autosomal dominant disorder characterized by the occurrence of multiple BCCs, but are also the most frequent mutations observed in sporadic BCCs. PTCH1 encodes for PTCH1 protein, the most important negative regulator of the Hedgehog (Hh) pathway. There are numerous studies confirming Hh pathway involvement in BCC pathogenesis. Although Hh pathway has been intensively investigated, it remains incompletely elucidated. Recent studies on BCC tumorigenesis have shown that in addition to Hh pathway, there are other signaling pathways involved in BCC development. In this review, we present recent advances in BCC carcinogenesis." @default.
- W3087536359 created "2020-09-25" @default.
- W3087536359 creator A5006994736 @default.
- W3087536359 creator A5020193072 @default.
- W3087536359 creator A5021772618 @default.
- W3087536359 creator A5030012165 @default.
- W3087536359 creator A5072932195 @default.
- W3087536359 creator A5073876041 @default.
- W3087536359 creator A5074046600 @default.
- W3087536359 creator A5075398539 @default.
- W3087536359 date "2020-09-18" @default.
- W3087536359 modified "2023-09-26" @default.
- W3087536359 title "Recent Advances in Signaling Pathways Comprehension as Carcinogenesis Triggers in Basal Cell Carcinoma" @default.
- W3087536359 cites W140354049 @default.
- W3087536359 cites W1508615665 @default.
- W3087536359 cites W1554676002 @default.
- W3087536359 cites W1570350325 @default.
- W3087536359 cites W1829157304 @default.
- W3087536359 cites W1839148191 @default.
- W3087536359 cites W1870241156 @default.
- W3087536359 cites W1934272095 @default.
- W3087536359 cites W1943853957 @default.
- W3087536359 cites W1965766554 @default.
- W3087536359 cites W1970915933 @default.
- W3087536359 cites W1973133925 @default.
- W3087536359 cites W1979872069 @default.
- W3087536359 cites W1984752955 @default.
- W3087536359 cites W1987756097 @default.
- W3087536359 cites W1987774694 @default.
- W3087536359 cites W1989652769 @default.
- W3087536359 cites W2001994340 @default.
- W3087536359 cites W2002091909 @default.
- W3087536359 cites W2007073167 @default.
- W3087536359 cites W2042825747 @default.
- W3087536359 cites W2047141919 @default.
- W3087536359 cites W2048774760 @default.
- W3087536359 cites W2061047690 @default.
- W3087536359 cites W2065520466 @default.
- W3087536359 cites W2072702976 @default.
- W3087536359 cites W2075264134 @default.
- W3087536359 cites W2080423078 @default.
- W3087536359 cites W2085186792 @default.
- W3087536359 cites W2091113670 @default.
- W3087536359 cites W2094569187 @default.
- W3087536359 cites W2097117196 @default.
- W3087536359 cites W2101616608 @default.
- W3087536359 cites W2106525695 @default.
- W3087536359 cites W2108444995 @default.
- W3087536359 cites W2108961002 @default.
- W3087536359 cites W2110321605 @default.
- W3087536359 cites W2110705645 @default.
- W3087536359 cites W2114121264 @default.
- W3087536359 cites W2114882581 @default.
- W3087536359 cites W2119265590 @default.
- W3087536359 cites W2120010339 @default.
- W3087536359 cites W2126490517 @default.
- W3087536359 cites W2126602709 @default.
- W3087536359 cites W2126726246 @default.
- W3087536359 cites W2138305199 @default.
- W3087536359 cites W2139160260 @default.
- W3087536359 cites W2141453076 @default.
- W3087536359 cites W2153635433 @default.
- W3087536359 cites W2155312919 @default.
- W3087536359 cites W2156148020 @default.
- W3087536359 cites W2157305173 @default.
- W3087536359 cites W2157376707 @default.
- W3087536359 cites W2158011910 @default.
- W3087536359 cites W2162489686 @default.
- W3087536359 cites W2169624146 @default.
- W3087536359 cites W2209389920 @default.
- W3087536359 cites W2238774085 @default.
- W3087536359 cites W2267750090 @default.
- W3087536359 cites W2293178613 @default.
- W3087536359 cites W2303572252 @default.
- W3087536359 cites W2331641317 @default.
- W3087536359 cites W2341152357 @default.
- W3087536359 cites W2344752282 @default.
- W3087536359 cites W2493839764 @default.
- W3087536359 cites W2509014393 @default.
- W3087536359 cites W2526421941 @default.
- W3087536359 cites W2583439556 @default.
- W3087536359 cites W2594825839 @default.
- W3087536359 cites W2620716110 @default.
- W3087536359 cites W2744377419 @default.
- W3087536359 cites W2746951431 @default.
- W3087536359 cites W2749640902 @default.
- W3087536359 cites W2755269207 @default.
- W3087536359 cites W2757589713 @default.
- W3087536359 cites W2768236252 @default.
- W3087536359 cites W2786577426 @default.
- W3087536359 cites W2787477673 @default.
- W3087536359 cites W2789984671 @default.
- W3087536359 cites W2791430989 @default.
- W3087536359 cites W2792238344 @default.
- W3087536359 cites W2792568261 @default.
- W3087536359 cites W2805145386 @default.
- W3087536359 cites W2828515008 @default.
- W3087536359 cites W2854100840 @default.