Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087548944> ?p ?o ?g. }
- W3087548944 abstract "Tuberous sclerosis complex (TSC) represents the prototypic monogenic disorder of the mammalian target of rapamycin (mTOR) pathway dysregulation. It provides the rational mechanistic basis of a direct link between gene mutation and brain pathology (structural and functional abnormalities) associated with a complex clinical phenotype including epilepsy, autism and intellectual disability. So far, research conducted in TSC has been largely neuron-oriented. However, the neuropathological hallmarks of TSC and other malformations of cortical development also includes major morphological and functional changes in glial cells involving astrocytes, oligodendrocytes, NG2 glia, and microglia. These cells and their inter-glial crosstalk may offer new insights into the common neurobiological mechanisms underlying epilepsy and the complex cognitive and behavioral comorbidities that are characteristic of the spectrum of mTOR-associated neurodevelopmental disorders. This review will focus on the role of glial dysfunction, the interaction between glia related to mTOR hyperactivity and its contribution to epileptogenesis in TSC. Moreover, we will discuss how understanding glial abnormalities in TSC might give valuable insight into the pathophysiological mechanisms that could help to develop novel therapeutic approaches for TSC or other pathologies characterized by glial dysfunction and acquired mTOR hyperactivation." @default.
- W3087548944 created "2020-09-25" @default.
- W3087548944 creator A5002398450 @default.
- W3087548944 creator A5003646819 @default.
- W3087548944 creator A5031844504 @default.
- W3087548944 creator A5047746348 @default.
- W3087548944 creator A5073864628 @default.
- W3087548944 creator A5078879010 @default.
- W3087548944 date "2020-09-17" @default.
- W3087548944 modified "2023-10-14" @default.
- W3087548944 title "Tuberous Sclerosis Complex as Disease Model for Investigating mTOR-Related Gliopathy During Epileptogenesis" @default.
- W3087548944 cites W1486174444 @default.
- W3087548944 cites W1578183568 @default.
- W3087548944 cites W1590854724 @default.
- W3087548944 cites W1608451494 @default.
- W3087548944 cites W1618035875 @default.
- W3087548944 cites W1675182861 @default.
- W3087548944 cites W1768846296 @default.
- W3087548944 cites W1817666133 @default.
- W3087548944 cites W1859164056 @default.
- W3087548944 cites W1860574066 @default.
- W3087548944 cites W1867691379 @default.
- W3087548944 cites W1886226115 @default.
- W3087548944 cites W1912652862 @default.
- W3087548944 cites W1923381385 @default.
- W3087548944 cites W1938006959 @default.
- W3087548944 cites W1943645390 @default.
- W3087548944 cites W1953992154 @default.
- W3087548944 cites W1957339526 @default.
- W3087548944 cites W1965719749 @default.
- W3087548944 cites W1966141463 @default.
- W3087548944 cites W1966158216 @default.
- W3087548944 cites W1970840600 @default.
- W3087548944 cites W1972080457 @default.
- W3087548944 cites W1972958417 @default.
- W3087548944 cites W1973785682 @default.
- W3087548944 cites W1974666830 @default.
- W3087548944 cites W1975045883 @default.
- W3087548944 cites W1975954062 @default.
- W3087548944 cites W1976152949 @default.
- W3087548944 cites W1977481223 @default.
- W3087548944 cites W1979054538 @default.
- W3087548944 cites W1982574163 @default.
- W3087548944 cites W1983045666 @default.
- W3087548944 cites W1983100194 @default.
- W3087548944 cites W1985286185 @default.
- W3087548944 cites W1985950007 @default.
- W3087548944 cites W1988976106 @default.
- W3087548944 cites W1989756662 @default.
- W3087548944 cites W1991816820 @default.
- W3087548944 cites W1992509114 @default.
- W3087548944 cites W1992777106 @default.
- W3087548944 cites W1995291424 @default.
- W3087548944 cites W1996024251 @default.
- W3087548944 cites W1996556344 @default.
- W3087548944 cites W1999952543 @default.
- W3087548944 cites W2001056499 @default.
- W3087548944 cites W2002313452 @default.
- W3087548944 cites W2002327194 @default.
- W3087548944 cites W2003646464 @default.
- W3087548944 cites W2003674452 @default.
- W3087548944 cites W2004923472 @default.
- W3087548944 cites W2005387121 @default.
- W3087548944 cites W2006789916 @default.
- W3087548944 cites W2008195992 @default.
- W3087548944 cites W2010630035 @default.
- W3087548944 cites W2013796884 @default.
- W3087548944 cites W2014962014 @default.
- W3087548944 cites W2015778757 @default.
- W3087548944 cites W2016860846 @default.
- W3087548944 cites W2017245404 @default.
- W3087548944 cites W2018558728 @default.
- W3087548944 cites W2022633707 @default.
- W3087548944 cites W2024096360 @default.
- W3087548944 cites W2024191529 @default.
- W3087548944 cites W2026029720 @default.
- W3087548944 cites W2028230396 @default.
- W3087548944 cites W2029190354 @default.
- W3087548944 cites W2032285200 @default.
- W3087548944 cites W2033322963 @default.
- W3087548944 cites W2033581608 @default.
- W3087548944 cites W2034300348 @default.
- W3087548944 cites W2035220839 @default.
- W3087548944 cites W2035495486 @default.
- W3087548944 cites W2035784392 @default.
- W3087548944 cites W2040322783 @default.
- W3087548944 cites W2043919941 @default.
- W3087548944 cites W2044161108 @default.
- W3087548944 cites W2046323357 @default.
- W3087548944 cites W2049212652 @default.
- W3087548944 cites W2049264566 @default.
- W3087548944 cites W2049381107 @default.
- W3087548944 cites W2050382124 @default.
- W3087548944 cites W2052285428 @default.
- W3087548944 cites W2054201119 @default.
- W3087548944 cites W2056084345 @default.
- W3087548944 cites W2056111473 @default.
- W3087548944 cites W2056994440 @default.
- W3087548944 cites W2057496261 @default.
- W3087548944 cites W2059813092 @default.