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- W3087549452 abstract "Thermo transient receptor potential (thermoTRP) channels are some of the most intensely pursued therapeutic targets of the past decade. They are considered promising targets of numerous diseases including chronic pain and cancer. Modulators of these proteins, in particular TRPV1-4, TRPM8 and TRPA1, have reached clinical development, but none has been approved for clinical practice yet.The therapeutic potential of targeting thermoTRP channels is discussed. The discussion is centered on our experience and on available data found in SciFinder, PubMed, and ClinicalTrials.gov database from the past decade. This review focuses on the therapeutic progress concerning this family of channels, including strategies to improve their therapeutic index for overcoming adverse effects.Although thermoTRPs are pivotal drug targets, translation to the clinic has faced two key problems, (i) unforeseen side effects in Phase I trials and, (ii) poor clinical efficacy in Phase II trials. Thus, there is a need for (i) an enhanced understanding of the physiological role of these channels in tissues and organs and (ii) the development of human-based pre-clinical models with higher clinical translation. Furthermore, progress in nanotechnology-based delivery strategies will positively impact thermoTRP human pharmacology." @default.
- W3087549452 created "2020-09-25" @default.
- W3087549452 creator A5032753448 @default.
- W3087549452 creator A5058686844 @default.
- W3087549452 creator A5071387984 @default.
- W3087549452 creator A5083885349 @default.
- W3087549452 date "2020-09-29" @default.
- W3087549452 modified "2023-10-18" @default.
- W3087549452 title "Investigational drugs in early phase clinical trials targeting thermotransient receptor potential (thermoTRP) channels" @default.
- W3087549452 cites W125614691 @default.
- W3087549452 cites W1495617953 @default.
- W3087549452 cites W1571837352 @default.
- W3087549452 cites W184383079 @default.
- W3087549452 cites W1965962126 @default.
- W3087549452 cites W1973619060 @default.
- W3087549452 cites W1974213802 @default.
- W3087549452 cites W1983271493 @default.
- W3087549452 cites W1985474963 @default.
- W3087549452 cites W1986697368 @default.
- W3087549452 cites W2007062738 @default.
- W3087549452 cites W2023578856 @default.
- W3087549452 cites W2023793701 @default.
- W3087549452 cites W2032462838 @default.
- W3087549452 cites W2033620602 @default.
- W3087549452 cites W2035526473 @default.
- W3087549452 cites W2040593216 @default.
- W3087549452 cites W2043088091 @default.
- W3087549452 cites W2047246302 @default.
- W3087549452 cites W2047475852 @default.
- W3087549452 cites W2051507271 @default.
- W3087549452 cites W2051511150 @default.
- W3087549452 cites W2054753975 @default.
- W3087549452 cites W2057154060 @default.
- W3087549452 cites W2069660291 @default.
- W3087549452 cites W2072890489 @default.
- W3087549452 cites W2076992552 @default.
- W3087549452 cites W2079720998 @default.
- W3087549452 cites W2082938503 @default.
- W3087549452 cites W2085446663 @default.
- W3087549452 cites W2094798729 @default.
- W3087549452 cites W2107705149 @default.
- W3087549452 cites W2108995593 @default.
- W3087549452 cites W2114933967 @default.
- W3087549452 cites W2121534390 @default.
- W3087549452 cites W2125674387 @default.
- W3087549452 cites W2129155568 @default.
- W3087549452 cites W2133738718 @default.
- W3087549452 cites W2135741627 @default.
- W3087549452 cites W2138376387 @default.
- W3087549452 cites W2146817455 @default.
- W3087549452 cites W2161011502 @default.
- W3087549452 cites W2194570164 @default.
- W3087549452 cites W2206256348 @default.
- W3087549452 cites W2303419544 @default.
- W3087549452 cites W2312180837 @default.
- W3087549452 cites W2412873074 @default.
- W3087549452 cites W2433496182 @default.
- W3087549452 cites W2472020357 @default.
- W3087549452 cites W2488287182 @default.
- W3087549452 cites W2491911250 @default.
- W3087549452 cites W2512337011 @default.
- W3087549452 cites W2514632948 @default.
- W3087549452 cites W2519510195 @default.
- W3087549452 cites W2562021066 @default.
- W3087549452 cites W2598062636 @default.
- W3087549452 cites W2611575983 @default.
- W3087549452 cites W2613884442 @default.
- W3087549452 cites W2618247170 @default.
- W3087549452 cites W2729902699 @default.
- W3087549452 cites W2736827087 @default.
- W3087549452 cites W2749617441 @default.
- W3087549452 cites W2766994258 @default.
- W3087549452 cites W2776648429 @default.
- W3087549452 cites W2782274917 @default.
- W3087549452 cites W2782814984 @default.
- W3087549452 cites W2787416181 @default.
- W3087549452 cites W2790248681 @default.
- W3087549452 cites W2796999552 @default.
- W3087549452 cites W2799833157 @default.
- W3087549452 cites W2800495671 @default.
- W3087549452 cites W2806670887 @default.
- W3087549452 cites W2808249077 @default.
- W3087549452 cites W2810796788 @default.
- W3087549452 cites W2889135197 @default.
- W3087549452 cites W2899445806 @default.
- W3087549452 cites W2901639929 @default.
- W3087549452 cites W2902034312 @default.
- W3087549452 cites W2911053863 @default.
- W3087549452 cites W2913311808 @default.
- W3087549452 cites W2915842172 @default.
- W3087549452 cites W2922164342 @default.
- W3087549452 cites W2946938349 @default.
- W3087549452 cites W2953112072 @default.
- W3087549452 cites W2962772776 @default.
- W3087549452 cites W2966310203 @default.
- W3087549452 cites W2978320165 @default.
- W3087549452 cites W2980339319 @default.
- W3087549452 cites W2981833214 @default.