Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087571605> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W3087571605 abstract "Betamethasone (BET) is prohibited in sports competitions when administered by systemic routes, and it is allowed by other routes for therapeutic purposes. In out-of-competition periods, there is no restriction of use. The present work aimed to assess the urinary excretion of BET and its metabolites after allowed and prohibited administrations to verify the suitability of the current reporting level of 30 ng/ml used to distinguish allowed and prohibited administrations and to establish washout periods for oral and intramuscular (IM) administrations when out-of-competition treatments are needed. BET was administered to healthy volunteers by different routes: topical (10 mg/day for 5 days, n = 6 males), intranasal (320 μg/day for 3 days, n = 4 males and 4 females), oral (0.5 mg, n = 8 males) or IM (6 mg, n = 6 males, or 12 mg, n = 4 males and 4 females). Urine and plasma samples collected before and after administration were analysed using liquid chromatography-tandem mass spectrometry. Among all studied metabolites, the parent drug was selected as the best discriminatory marker. After topical administration, BET concentrations were lower than 6.6 ng/ml. However, after intranasal treatment, some samples at concentrations close to or higher than 30 ng/ml were detected, suggesting the need to revise the current reporting level. Urinary concentrations after oral and intranasal administrations were similar, and after IM administration, concentrations were much higher. Taking into account all information, a urinary reporting level of 60 ng/ml is proposed. Washout periods of at least 48 and 96 h are recommended after oral and IM administrations, respectively." @default.
- W3087571605 created "2020-09-25" @default.
- W3087571605 creator A5010854293 @default.
- W3087571605 creator A5033049869 @default.
- W3087571605 creator A5043814428 @default.
- W3087571605 creator A5060663068 @default.
- W3087571605 creator A5066941946 @default.
- W3087571605 creator A5083373223 @default.
- W3087571605 date "2020-10-20" @default.
- W3087571605 modified "2023-10-17" @default.
- W3087571605 title "Elimination profiles of betamethasone after different administration routes: Evaluation of the reporting level and washout periods to ensure safe therapeutic administrations" @default.
- W3087571605 cites W1574594312 @default.
- W3087571605 cites W1947306180 @default.
- W3087571605 cites W1964645074 @default.
- W3087571605 cites W1970303549 @default.
- W3087571605 cites W1979798926 @default.
- W3087571605 cites W1984546189 @default.
- W3087571605 cites W2014224511 @default.
- W3087571605 cites W2021540071 @default.
- W3087571605 cites W2071308799 @default.
- W3087571605 cites W2078032440 @default.
- W3087571605 cites W2086409607 @default.
- W3087571605 cites W2116283753 @default.
- W3087571605 cites W2116446494 @default.
- W3087571605 cites W2133744202 @default.
- W3087571605 cites W2145864819 @default.
- W3087571605 cites W2171491618 @default.
- W3087571605 cites W2275153714 @default.
- W3087571605 cites W2275931631 @default.
- W3087571605 cites W2293356638 @default.
- W3087571605 cites W2320702531 @default.
- W3087571605 cites W2520503986 @default.
- W3087571605 cites W2945423696 @default.
- W3087571605 cites W2949097357 @default.
- W3087571605 cites W2958573663 @default.
- W3087571605 cites W2963042124 @default.
- W3087571605 cites W2987778123 @default.
- W3087571605 cites W2991836328 @default.
- W3087571605 doi "https://doi.org/10.1002/dta.2928" @default.
- W3087571605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32949107" @default.
- W3087571605 hasPublicationYear "2020" @default.
- W3087571605 type Work @default.
- W3087571605 sameAs 3087571605 @default.
- W3087571605 citedByCount "7" @default.
- W3087571605 countsByYear W30875716052021 @default.
- W3087571605 countsByYear W30875716052022 @default.
- W3087571605 countsByYear W30875716052023 @default.
- W3087571605 crossrefType "journal-article" @default.
- W3087571605 hasAuthorship W3087571605A5010854293 @default.
- W3087571605 hasAuthorship W3087571605A5033049869 @default.
- W3087571605 hasAuthorship W3087571605A5043814428 @default.
- W3087571605 hasAuthorship W3087571605A5060663068 @default.
- W3087571605 hasAuthorship W3087571605A5066941946 @default.
- W3087571605 hasAuthorship W3087571605A5083373223 @default.
- W3087571605 hasConcept C10146269 @default.
- W3087571605 hasConcept C126322002 @default.
- W3087571605 hasConcept C2777056448 @default.
- W3087571605 hasConcept C2777288759 @default.
- W3087571605 hasConcept C2780026642 @default.
- W3087571605 hasConcept C2781162121 @default.
- W3087571605 hasConcept C71839028 @default.
- W3087571605 hasConcept C71924100 @default.
- W3087571605 hasConcept C77411442 @default.
- W3087571605 hasConcept C85663871 @default.
- W3087571605 hasConcept C98274493 @default.
- W3087571605 hasConceptScore W3087571605C10146269 @default.
- W3087571605 hasConceptScore W3087571605C126322002 @default.
- W3087571605 hasConceptScore W3087571605C2777056448 @default.
- W3087571605 hasConceptScore W3087571605C2777288759 @default.
- W3087571605 hasConceptScore W3087571605C2780026642 @default.
- W3087571605 hasConceptScore W3087571605C2781162121 @default.
- W3087571605 hasConceptScore W3087571605C71839028 @default.
- W3087571605 hasConceptScore W3087571605C71924100 @default.
- W3087571605 hasConceptScore W3087571605C77411442 @default.
- W3087571605 hasConceptScore W3087571605C85663871 @default.
- W3087571605 hasConceptScore W3087571605C98274493 @default.
- W3087571605 hasFunder F4320321049 @default.
- W3087571605 hasLocation W30875716051 @default.
- W3087571605 hasLocation W30875716052 @default.
- W3087571605 hasOpenAccess W3087571605 @default.
- W3087571605 hasPrimaryLocation W30875716051 @default.
- W3087571605 hasRelatedWork W10927703 @default.
- W3087571605 hasRelatedWork W12104161 @default.
- W3087571605 hasRelatedWork W1233682 @default.
- W3087571605 hasRelatedWork W13031665 @default.
- W3087571605 hasRelatedWork W14438563 @default.
- W3087571605 hasRelatedWork W16407613 @default.
- W3087571605 hasRelatedWork W17559820 @default.
- W3087571605 hasRelatedWork W18252752 @default.
- W3087571605 hasRelatedWork W3425159 @default.
- W3087571605 hasRelatedWork W9635424 @default.
- W3087571605 isParatext "false" @default.
- W3087571605 isRetracted "false" @default.
- W3087571605 magId "3087571605" @default.
- W3087571605 workType "article" @default.