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- W3087577251 abstract "Three-dimensional lung organoids (LOs) derived from pluripotent stem cells have the potential to enhance our understanding of disease mechanisms and to enable novel therapeutic approaches in neonates with pulmonary disorders. We established a reproducible ex vivo model of lung development using transgene-free human induced pluripotent stem cells generated from fetuses and infants with Bochdalek congenital diaphragmatic hernia (CDH), a polygenic disorder associated with fetal lung compression and pulmonary hypoplasia at birth. Molecular and cellular comparisons of CDH LOs revealed impaired generation of NKX2.1+ progenitors, type II alveolar epithelial cells, and PDGFRα+ myofibroblasts. We then subjected these LOs to disease relevant mechanical cues through ex vivo compression and observed significant changes in genes associated with pulmonary progenitors, alveolar epithelial cells, and mesenchymal fibroblasts. Collectively, these data suggest both primary cell-intrinsic and secondary mechanical causes of CDH lung hypoplasia and support the use of this stem cell-based approach for disease modeling in CDH." @default.
- W3087577251 created "2020-09-25" @default.
- W3087577251 creator A5013849551 @default.
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- W3087577251 creator A5076851220 @default.
- W3087577251 date "2020-09-19" @default.
- W3087577251 modified "2023-10-04" @default.
- W3087577251 title "Human induced pluripotent stem cell-derived lung organoids in an ex vivo model of the congenital diaphragmatic hernia fetal lung" @default.
- W3087577251 cites W1603508604 @default.
- W3087577251 cites W1607599317 @default.
- W3087577251 cites W166051137 @default.
- W3087577251 cites W1797883911 @default.
- W3087577251 cites W1967351154 @default.
- W3087577251 cites W1971817485 @default.
- W3087577251 cites W1973418722 @default.
- W3087577251 cites W1979119679 @default.
- W3087577251 cites W1980909153 @default.
- W3087577251 cites W1982542661 @default.
- W3087577251 cites W1983308656 @default.
- W3087577251 cites W1989687656 @default.
- W3087577251 cites W1992117973 @default.
- W3087577251 cites W1998344495 @default.
- W3087577251 cites W2001622142 @default.
- W3087577251 cites W2007835635 @default.
- W3087577251 cites W2014482130 @default.
- W3087577251 cites W2018493960 @default.
- W3087577251 cites W2018536236 @default.
- W3087577251 cites W2024931422 @default.
- W3087577251 cites W2032024477 @default.
- W3087577251 cites W2035997865 @default.
- W3087577251 cites W2037426808 @default.
- W3087577251 cites W2042024902 @default.
- W3087577251 cites W2043781335 @default.
- W3087577251 cites W2045474570 @default.
- W3087577251 cites W2050308681 @default.
- W3087577251 cites W2054572850 @default.
- W3087577251 cites W2054672459 @default.
- W3087577251 cites W2056784708 @default.
- W3087577251 cites W2056844005 @default.
- W3087577251 cites W2062664804 @default.
- W3087577251 cites W2065432305 @default.
- W3087577251 cites W2067377225 @default.
- W3087577251 cites W2068552004 @default.
- W3087577251 cites W2078930878 @default.
- W3087577251 cites W2088280078 @default.
- W3087577251 cites W2089397734 @default.
- W3087577251 cites W2097795961 @default.
- W3087577251 cites W2103075021 @default.
- W3087577251 cites W2103449067 @default.
- W3087577251 cites W2104561957 @default.
- W3087577251 cites W2107567984 @default.
- W3087577251 cites W2114501423 @default.
- W3087577251 cites W2115586501 @default.
- W3087577251 cites W2118576867 @default.
- W3087577251 cites W2124616538 @default.
- W3087577251 cites W2127121356 @default.
- W3087577251 cites W2139430128 @default.
- W3087577251 cites W2142766854 @default.
- W3087577251 cites W2143849836 @default.
- W3087577251 cites W2144302454 @default.
- W3087577251 cites W2145739182 @default.
- W3087577251 cites W2147132294 @default.
- W3087577251 cites W2147623970 @default.
- W3087577251 cites W2155579187 @default.
- W3087577251 cites W2156862506 @default.
- W3087577251 cites W2158934501 @default.
- W3087577251 cites W2164432347 @default.
- W3087577251 cites W2167107449 @default.
- W3087577251 cites W2279247140 @default.
- W3087577251 cites W2290215259 @default.
- W3087577251 cites W2294185515 @default.
- W3087577251 cites W2314447935 @default.
- W3087577251 cites W2334861188 @default.
- W3087577251 cites W2396863692 @default.
- W3087577251 cites W2414322945 @default.
- W3087577251 cites W2440232853 @default.
- W3087577251 cites W2489609710 @default.
- W3087577251 cites W2515333543 @default.
- W3087577251 cites W2527207446 @default.
- W3087577251 cites W2535716897 @default.
- W3087577251 cites W2543020994 @default.
- W3087577251 cites W2543445477 @default.
- W3087577251 cites W2562959508 @default.
- W3087577251 cites W2585861613 @default.
- W3087577251 cites W2606582949 @default.
- W3087577251 cites W2609587333 @default.
- W3087577251 cites W2609826259 @default.
- W3087577251 cites W2617381634 @default.
- W3087577251 cites W2743672430 @default.
- W3087577251 cites W2765689631 @default.
- W3087577251 cites W2884004971 @default.
- W3087577251 cites W2884005293 @default.
- W3087577251 cites W2899370851 @default.
- W3087577251 cites W2909592500 @default.