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• W3087594184 endingPage "105673" @default.
• W3087594184 startingPage "105673" @default.
• W3087594184 abstract "The main objective of the work was to investigate how the dynamics of inhalation affect aerosol release process in real-time, with an unsteady airflow through passive dry powder inhalers (DPIs) of comparable airflow resistance, but different principle of powder release. It consists of two complementary studies, concerning dynamics of controlled aerosol release (emission kinetics) and dynamics of aerosol generation (aerosol size characteristics in time series).Aerosol behavior of the powder was studied experimentally at the outlet of the inhalers: RS01 inhaler (Plastiape Spa, Osnago LC, Lombardy, Italy) and Turbospin (Ph&T, Milano, Lombardy, Italy). Two breathing profiles were analyzed throughout the study. Timing of aerosol emission was done by light scattering. Aerosol characterization was done by laser diffraction. It resulted in time evolution of volume concentration and volumetric particle size distribution.Both the design of the passive DPI inhaler and the dynamics of the inhalation (along with its intensification) influence the course of the aerosol generation and emission. The process of aerosol emission occurs only in the initial part of the inhalation process, before the peak inspiratory flow rate is established. This part is strongly responsible for the quality of the aerosol emitted from the device and consequently will potentially influence the drug delivery. • The study concerns dynamics of aerosol release (timing of emission event). • Aerosol emission occurs in the beginning of the inhalation, before the peak flow. • Time evolution of particle size characteristics at inhalers's outlet is studied. • DPI inhaler's design and inhalation dynamics affect quality of emitted aerosol. • DPI performance is discussed in terms of inspiratory effort (work of breathing)." @default.
• W3087594184 created "2020-09-25" @default.
• W3087594184 creator A5022552496 @default.
• W3087594184 creator A5030615263 @default.
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• W3087594184 date "2021-01-01" @default.
• W3087594184 modified "2023-10-17" @default.
• W3087594184 title "Dynamics of aerosol generation and release – Dry powder inhaler performance considerations" @default.
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• W3087594184 doi "https://doi.org/10.1016/j.jaerosci.2020.105673" @default.
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