FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087619077> ?p ?o ?g. }

• W3087619077 endingPage "71" @default.
• W3087619077 startingPage "64" @default.
• W3087619077 abstract "Objective Polypharmacy (PP) is a common problem among the older adults and has a potential effect on health-related problems. However, the significance of PP in older advanced non–small cell lung cancer (NSCLC) patients and those on oral molecular-targeted anticancer agents is unclear. Materials and methods This retrospective, nonrandomized study reviewed the records of 334 advanced NSCLC patients who underwent epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) treatment. PP was defined as ≥ 5 concomitant medications. Potentially inappropriate medication (PIM) use was measured using the updated screening tool of older people's prescriptions (STOPP) ver. 2 criteria. We also estimated survival distributions using the Kaplan–Meier method, compared between–group differences using the log-rank test, explored potential predictors of survival using Cox regression, and performed cluster analysis to identify factors affecting multiple-medication use. Results The PP and PIM use prevalence was 38.4% and 31.9%, respectively. The median overall survival (OS) for PP(+) and PP(−) patients was 19.4 and 27.3 months, respectively. Multivariate analysis revealed a significant correlation between PP and OS. The frequency of unexpected hospitalization during EGFR-TKI treatment was higher in PP(+) patients compared to PP(−) patients (49.4% vs. 29.4%; odds ratio = 2.34). Conclusion PP is an independent prognostic factor in older advanced NSCLC patients taking EGFR-TKIs. PP can be used as a simple indicator of such patients' comorbidities and symptoms or as a predictive marker of unexpected hospitalization during treatment." @default.
• W3087619077 created "2020-09-25" @default.
• W3087619077 creator A5025868058 @default.
• W3087619077 creator A5049861151 @default.
• W3087619077 creator A5054884728 @default.
• W3087619077 creator A5055738561 @default.
• W3087619077 creator A5062162291 @default.
• W3087619077 date "2021-01-01" @default.
• W3087619077 modified "2023-09-25" @default.
• W3087619077 title "Polypharmacy among older advanced lung cancer patients taking EGFR tyrosine kinase inhibitors" @default.
• W3087619077 cites W1538368282 @default.
• W3087619077 cites W1865977567 @default.
• W3087619077 cites W1967113409 @default.
• W3087619077 cites W1972148020 @default.
• W3087619077 cites W1985556537 @default.
• W3087619077 cites W2000445173 @default.
• W3087619077 cites W2022908826 @default.
• W3087619077 cites W2029922515 @default.
• W3087619077 cites W2030460251 @default.
• W3087619077 cites W2038982031 @default.
• W3087619077 cites W2057780602 @default.
• W3087619077 cites W2064470295 @default.
• W3087619077 cites W2070498739 @default.
• W3087619077 cites W2071498651 @default.
• W3087619077 cites W2074522232 @default.
• W3087619077 cites W2105871302 @default.
• W3087619077 cites W2107243894 @default.
• W3087619077 cites W2109678955 @default.
• W3087619077 cites W2110941552 @default.
• W3087619077 cites W2130510785 @default.
• W3087619077 cites W2148659963 @default.
• W3087619077 cites W2154692607 @default.
• W3087619077 cites W2159091303 @default.
• W3087619077 cites W2166584341 @default.
• W3087619077 cites W2167600867 @default.
• W3087619077 cites W2172038537 @default.
• W3087619077 cites W2225150008 @default.
• W3087619077 cites W2479908431 @default.
• W3087619077 cites W2484071785 @default.
• W3087619077 cites W2515885770 @default.
• W3087619077 cites W2559732081 @default.
• W3087619077 cites W2560717039 @default.
• W3087619077 cites W2593089142 @default.
• W3087619077 cites W2595272838 @default.
• W3087619077 cites W2743717700 @default.
• W3087619077 cites W2748446166 @default.
• W3087619077 cites W2793612529 @default.
• W3087619077 cites W2794077735 @default.
• W3087619077 cites W2794687272 @default.
• W3087619077 cites W2805354595 @default.
• W3087619077 cites W2808310641 @default.
• W3087619077 cites W2917504199 @default.
• W3087619077 cites W2933418685 @default.
• W3087619077 cites W2937223370 @default.
• W3087619077 cites W2978533908 @default.
• W3087619077 cites W2987053327 @default.
• W3087619077 cites W2989811796 @default.
• W3087619077 cites W2990041408 @default.
• W3087619077 cites W4256661845 @default.
• W3087619077 doi "https://doi.org/10.1016/j.jgo.2020.09.011" @default.
• W3087619077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32952094" @default.
• W3087619077 hasPublicationYear "2021" @default.
• W3087619077 type Work @default.
• W3087619077 sameAs 3087619077 @default.
• W3087619077 citedByCount "12" @default.
• W3087619077 countsByYear W30876190772021 @default.
• W3087619077 countsByYear W30876190772022 @default.
• W3087619077 countsByYear W30876190772023 @default.
• W3087619077 crossrefType "journal-article" @default.
• W3087619077 hasAuthorship W3087619077A5025868058 @default.
• W3087619077 hasAuthorship W3087619077A5049861151 @default.
• W3087619077 hasAuthorship W3087619077A5054884728 @default.
• W3087619077 hasAuthorship W3087619077A5055738561 @default.
• W3087619077 hasAuthorship W3087619077A5062162291 @default.
• W3087619077 hasBestOaLocation W30876190772 @default.
• W3087619077 hasConcept C121608353 @default.
• W3087619077 hasConcept C126322002 @default.
• W3087619077 hasConcept C143998085 @default.
• W3087619077 hasConcept C156957248 @default.
• W3087619077 hasConcept C2776256026 @default.
• W3087619077 hasConcept C2778820342 @default.
• W3087619077 hasConcept C2779384505 @default.
• W3087619077 hasConcept C36434225 @default.
• W3087619077 hasConcept C38180746 @default.
• W3087619077 hasConcept C50382708 @default.
• W3087619077 hasConcept C63363279 @default.
• W3087619077 hasConcept C71924100 @default.
• W3087619077 hasConceptScore W3087619077C121608353 @default.
• W3087619077 hasConceptScore W3087619077C126322002 @default.
• W3087619077 hasConceptScore W3087619077C143998085 @default.
• W3087619077 hasConceptScore W3087619077C156957248 @default.
• W3087619077 hasConceptScore W3087619077C2776256026 @default.
• W3087619077 hasConceptScore W3087619077C2778820342 @default.
• W3087619077 hasConceptScore W3087619077C2779384505 @default.
• W3087619077 hasConceptScore W3087619077C36434225 @default.
• W3087619077 hasConceptScore W3087619077C38180746 @default.
• W3087619077 hasConceptScore W3087619077C50382708 @default.
• W3087619077 hasConceptScore W3087619077C63363279 @default.

• next