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• W3087624096 abstract "Abstract Background Microglial function is vital for maintaining the health of the brain, and their activation is an essential component of neurodegeneration. There is significant research on factors that provoke “reactive” or “inflammatory” phenotypes in conditions of injury or disease. One such factor, exposure to the aggregated or oligomeric forms of α-synuclein, an abundant brain protein, plays an essential role in driving microglial activation; including chemotactic migration and production of inflammatory mediators in Lewy body (LB) diseases such as Parkinson’s disease. On the other hand, it is increasingly recognized that microglia also undergo changes, dependent on the cellular environment, that promote mainly reconstructive and anti-inflammatory functions, i.e., mostly desirable functions of microglia in a physiological state. What maintains microglia in this physiological state is essentially unknown. Methods In this study, using in vitro and in vivo models, we challenged primary microglia or BV2 microglia with LPS + IFN-γ, IL-4 + IL-13, α-synuclein monomer, and α-synuclein oligomer, and examined microglia phenotype and the underlying mechanism by RT-PCR, Western blot, ELISA, IF, IHC, Co-IP. Results We described a novel physiological function of α-synuclein, in which it modulates microglia toward an anti-inflammatory phenotype by interaction with extracellular signal-regulated kinase (ERK) and recruitment of the ERK, nuclear factor kappa B (NF-κB), and peroxisome proliferator-activated receptor γ (PPARγ) pathways. Conclusions These findings suggest a previously unrecognized function of monomeric α-synuclein that likely gives new insights into the pathogenesis and potential therapies for Lewy body-related diseases and beyond, given the abundance and multiple functions of α-synuclein in brain tissue." @default.
• W3087624096 created "2020-09-25" @default.
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• W3087624096 date "2020-09-17" @default.
• W3087624096 modified "2023-10-15" @default.
• W3087624096 title "Immunoregulation of microglial polarization: an unrecognized physiological function of α-synuclein" @default.
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• W3087624096 cites W1587360940 @default.
• W3087624096 cites W1588992473 @default.
• W3087624096 cites W1801221773 @default.
• W3087624096 cites W1841354354 @default.
• W3087624096 cites W1970553224 @default.
• W3087624096 cites W1974924674 @default.
• W3087624096 cites W1983808867 @default.
• W3087624096 cites W1984436706 @default.
• W3087624096 cites W1990473626 @default.
• W3087624096 cites W1993506756 @default.
• W3087624096 cites W1995590349 @default.
• W3087624096 cites W1998051691 @default.
• W3087624096 cites W2011361113 @default.
• W3087624096 cites W2014627341 @default.
• W3087624096 cites W2015283405 @default.
• W3087624096 cites W2019933368 @default.
• W3087624096 cites W2026717532 @default.
• W3087624096 cites W2031315586 @default.
• W3087624096 cites W2036606290 @default.
• W3087624096 cites W2046784631 @default.
• W3087624096 cites W2047585900 @default.
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• W3087624096 cites W2056990133 @default.
• W3087624096 cites W2065048465 @default.
• W3087624096 cites W2069893872 @default.
• W3087624096 cites W2076019198 @default.
• W3087624096 cites W2086050354 @default.
• W3087624096 cites W2094660330 @default.
• W3087624096 cites W2095376584 @default.
• W3087624096 cites W2097989918 @default.
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• W3087624096 cites W2128631317 @default.
• W3087624096 cites W2161163550 @default.
• W3087624096 cites W2167485774 @default.
• W3087624096 cites W2171281715 @default.
• W3087624096 cites W2313098434 @default.
• W3087624096 cites W2323768961 @default.
• W3087624096 cites W2336534940 @default.
• W3087624096 cites W2470741179 @default.
• W3087624096 cites W2497241389 @default.
• W3087624096 cites W2517534055 @default.
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• W3087624096 cites W2531001783 @default.
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• W3087624096 doi "https://doi.org/10.1186/s12974-020-01940-z" @default.
• W3087624096 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7500012" @default.
• W3087624096 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32943057" @default.
• W3087624096 hasPublicationYear "2020" @default.
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