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• W3087629206 abstract "To assess the effect of microfracture and biomimetic hydrogel scaffold on tendon-to-bone healing in a rabbit rotator cuff tear model.Gelatin and methacrylic anhydride were used to synthesize gelatin methacryloyl (GelMA). Then the GelMA were treated with ultraviolet rays and vacuum freeze-drying method to obtain a biomimetic hydrogel scaffold. The morphology of the scaffold was observed by gross observation and scanning electron microscope. Degradation of the scaffold was determined at different time points. Twenty-four adult New Zealand rabbits, weighting 2.8-3.5 kg and male or female, were surgically created the bilateral acute rotator cuff tear models. One shoulder was treated with microfractures on the footprint and transosseous suture (control group, n=24). The other shoulder was treated with the same way, except for putting the scaffold on the footprint before transosseous suture (experimental group, n=24). The general conditions of rabbits were observed postoperatively. Tendon-to-bone healing was evaluated by gross observation, Micro-CT, HE staining, and bio-mechanical testing at 4 and 8 weeks after operation.The scaffold was white and has a porous structure with pore size of 31.7-89.9 μm, which degraded slowly in PBS solution. The degradation rate was about 95% at 18 days. All the rabbits survived to the completion of the experiment. Micro-CT showed that there was no obvious defect and re-tear at the tendon-to-bone interface in both groups. No difference was found in bone mineral density (BMD), tissue mineral density (TMD), and bone volume/total volume (BV/TV) between the two groups at 4 and 8 weeks postoperatively ( P>0.05). HE staining showed that the fibrous scar tissue was the main component at the tendon-to-bone interface in the control group at 4 and 8 weeks postoperatively; the disorderly arranged mineralized cartilage and fibrocartilage formation were observed at the tendon-to-bone interface in the experimental group at 4 weeks, and the orderly arranged cartilage formation was observed at 8 weeks. Besides, the tendon maturation scores of the experimental group were significantly higher than those of the control group at 4 and 8 weeks ( P<0.05). There was no significant difference in the ultimate load to failure and stiffness between the two groups at 4 weeks ( P>0.05); the ultimate load to failure at 8 weeks was significantly higher in the experiment group than in the control group ( t=4.162, P=0.009), and no significant difference was found in stiffness between the two groups at 8 weeks ( t=2.286, P=0.071).Compared with microfracture alone, microfracture combined with biomimetic hydrogel scaffold can enhance tendon-to-bone healing and improve the ultimate load to failure in rabbits.探讨微骨折技术联合仿生水凝胶支架对兔肩袖损伤修补术后腱-骨愈合的影响。.利用明胶和甲基丙烯酸酐合成甲基丙烯酰胺基明胶，通过紫外光交联和真空冷冻干燥技术制备仿生水凝胶支架。大体观察支架颜色、性状后，扫描电镜观察其微观形貌，并行体外降解性能测试。取 24 只成年新西兰大白兔，雌雄不限，体质量 2.8～3.5 kg，建立双侧急性肩袖损伤模型后，随机取一侧行止点骨床微骨折处理联合穿骨肌腱修补术（对照组， n=24）；另一侧在微骨折处理后，将仿生水凝胶支架植入骨床，再行穿骨肌腱修补术（实验组， n=24）。术后观察动物一般情况，分别于术后 4、8 周取肩袖标本行大体观察、Micro-CT 检测、HE 染色和生物力学测试。.仿生水凝胶支架外观呈白色，具有丰富多孔结构，孔径为 31.7～89.9 μm，于 PBS 溶液中能缓慢降解，18 d 时降解率约为 95%。兔肩袖修补术后均存活至实验完成。大体观察示两组腱-骨界面未见明显缺损和再撕裂。Micro-CT 检测，术后 4、8 周两组骨密度、组织骨密度和骨体积分数差异均无统计学意义（ P>0.05）。HE 染色显示术后 4、8 周对照组腱-骨界面均以纤维瘢痕组织为主，而实验组术后 4 周腱-骨界面部分区域可见矿化软骨和纤维软骨形成，且术后 8 周软骨逐渐呈有序排列成过渡结构；术后 4、8 周，实验组肌腱成熟度评分均明显优于对照组（ P<0.05）。生物力学测试术后 4 周两组极限负荷和刚度差异无统计学意义（ P>0.05）；术后 8 周两组刚度差异无统计学意义（ t=2.286， P=0.071），但实验组极限负荷明显优于对照组（ t=4.162， P=0.009）。.与单纯微骨折技术相比，微骨折技术联合仿生水凝胶支架有利于兔肩袖腱-骨愈合，增强腱-骨界面抗拉性能。." @default.
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• W3087629206 date "2020-09-15" @default.
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• W3087629206 title "[Effect of microfracture combined with biomimetic hydrogel scaffold on rotator cuff tendon-to-bone healing in rabbits]." @default.
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• W3087629206 doi "https://doi.org/10.7507/1002-1892.202001029" @default.
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