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- W3087638535 endingPage "2135" @default.
- W3087638535 startingPage "2135" @default.
- W3087638535 abstract "Aggregation and deposition of β-amyloid and/or tau protein are the key neuropathological features in neurodegenerative disorders such as Alzheimer’s disease (AD) and other tauopathies including frontotemporal dementia (FTD). The interaction between oxidative stress, mitochondrial dysfunction and the impairment of calcium ions (Ca2+) homeostasis induced by misfolded tau and β-amyloid plays an important role in the progressive neuronal loss occurring in specific areas of the brain. In addition to the control of bioenergetics and ROS production, mitochondria are fine regulators of the cytosolic Ca2+ homeostasis that induce vital signalling mechanisms in excitable cells such as neurons. Impairment in the mitochondrial Ca2+ uptake through the mitochondrial Ca2+ uniporter (MCU) or release through the Na+/Ca2+ exchanger may lead to mitochondrial Ca2+ overload and opening of the permeability transition pore inducing neuronal death. Recent evidence suggests an important role for these mechanisms as the underlying causes for neuronal death in β-amyloid and tau pathology. The present review will focus on the mechanisms that lead to cytosolic and especially mitochondrial Ca2+ disturbances occurring in AD and tau-induced FTD, and propose possible therapeutic interventions for these disorders." @default.
- W3087638535 created "2020-09-25" @default.
- W3087638535 creator A5038020678 @default.
- W3087638535 creator A5055353781 @default.
- W3087638535 date "2020-09-21" @default.
- W3087638535 modified "2023-10-10" @default.
- W3087638535 title "Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology" @default.
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