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- W3087653162 abstract "Over the last two decades, the outcomes of patients with multiple myeloma (MM), a malignant plasma cells dyscrasia, have dramatically improved. The development and the introduction of the immunomodulatory drugs (IMiDs) which include thalidomide, lenalidomide, and pomalidomide, have contributed significantly to these improvements.The IMiDs have been shown a multitude of mechanisms of action, including antiangiogenic, cytotoxic and immunomodulatory. The more recent discoveries that the IMiDs bind to cereblon and thus regulate the ubiquitination of key transcription factors including IKZF1 and IKZF3, have provided new insight about their activities.The IMIDs are widely used in the treatment of the different setting of MM patients and particularly lenalidomide represents the backbone in the therapy of newly diagnosed transplant eligible and transplant ineligible patients, in the maintenance setting post-transplant and in the relapsed/refractory setting, while pomalidomide is currently utilized in the relapsed/refractory setting.Here the mechanisms of action, the clinical efficacy and the management of side effects are reviewed as well as the new classes of cereblon E3 ligase modulator (CELMoD) and their promising clinical data are described." @default.
- W3087653162 created "2020-09-25" @default.
- W3087653162 creator A5072331165 @default.
- W3087653162 creator A5073761054 @default.
- W3087653162 creator A5082831484 @default.
- W3087653162 creator A5083968415 @default.
- W3087653162 date "2021-01-01" @default.
- W3087653162 modified "2023-10-18" @default.
- W3087653162 title "Old and new generation immunomodulatory drugs in multiple myeloma" @default.
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