FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087656522> ?p ?o ?g. }

• W3087656522 endingPage "e000406" @default.
• W3087656522 startingPage "e000406" @default.
• W3087656522 abstract "Background Craniopharyngioma (CP) is a common refractory tumor of the central nervous system. However, little is known about the expression and clinical significance of B7 family ligands/receptors in CP patients. Thus, we conducted the present study to address this issue in a cohort of 132 CP cases. Methods We mapped and quantified the expression of B7 family ligands/receptors molecules programmed cell death ligand 1 (PD-L1), B7-H3, B7-H4 and V-domain Ig-containing suppressor of T cell activation (VISTA) in 89 adamantinomatous-type CP and 43 papillary-type CP samples using immunohistochemistry and immunofluorescence. Associations between the marker levels, clinicopathological variables and survival were evaluated. Results The positive rates of PD-L1, B7-H3, B7-H4 and VISTA in the cohort of 132 CP cases were 76.5%, 100%, 40.2% and 80.3%, respectively. The cut-off values of PD-L1, B7-H3, B7-H4 and PD-L1 expression were determined by survival receiver operating characteristic (ROC) package, which was 70, 182, 0 and 20, respectively. Elevated expressions of PD-L1, B7-H3, B7-H4 and VISTA were significantly associated with some clinicopathological characteristics. Kaplan-Meier analysis indicated that higher VISTA expressions correlated with better overall survival (OS) and progression-free survival (PFS) (p=0.0053 and p=0.0066, respectively). Multivariate Cox regression analysis indicated that VISTA was an independent prognostic factor for OS (p=0.018) but not for PFS (p=0.898). Conclusions We found variable expression of PD-L1, B7-H3, B7-H4 and VISTA proteins in CPs. The results suggest that the expression level of VISTA may be used as an important indicator to predict the OS and PFS of CPs. B7 family ligands/receptors could be potential immunotherapeutic targets when treating CPs." @default.
• W3087656522 created "2020-09-25" @default.
• W3087656522 creator A5004040364 @default.
• W3087656522 creator A5009606065 @default.
• W3087656522 creator A5017214879 @default.
• W3087656522 creator A5019429833 @default.
• W3087656522 creator A5041123392 @default.
• W3087656522 creator A5053275663 @default.
• W3087656522 creator A5074160443 @default.
• W3087656522 creator A5075546886 @default.
• W3087656522 creator A5076413653 @default.
• W3087656522 creator A5078512784 @default.
• W3087656522 creator A5090168066 @default.
• W3087656522 creator A5090533727 @default.
• W3087656522 creator A5091298949 @default.
• W3087656522 date "2020-09-01" @default.
• W3087656522 modified "2023-10-17" @default.
• W3087656522 title "Expression and clinical significance of PD-L1, B7-H3, B7-H4 and VISTA in craniopharyngioma" @default.
• W3087656522 cites W1964540534 @default.
• W3087656522 cites W2052727153 @default.
• W3087656522 cites W2060070314 @default.
• W3087656522 cites W2145756448 @default.
• W3087656522 cites W2166932124 @default.
• W3087656522 cites W2464921739 @default.
• W3087656522 cites W2505238445 @default.
• W3087656522 cites W2520062967 @default.
• W3087656522 cites W2559007087 @default.
• W3087656522 cites W2577007969 @default.
• W3087656522 cites W2585476654 @default.
• W3087656522 cites W2591674407 @default.
• W3087656522 cites W2592413467 @default.
• W3087656522 cites W2603526557 @default.
• W3087656522 cites W2612857312 @default.
• W3087656522 cites W2619198663 @default.
• W3087656522 cites W2728083530 @default.
• W3087656522 cites W2774416127 @default.
• W3087656522 cites W2788593837 @default.
• W3087656522 cites W2790470415 @default.
• W3087656522 cites W2790574591 @default.
• W3087656522 cites W2802324828 @default.
• W3087656522 cites W2883970691 @default.
• W3087656522 cites W2899296444 @default.
• W3087656522 cites W2915684185 @default.
• W3087656522 cites W2917853396 @default.
• W3087656522 cites W2925446385 @default.
• W3087656522 cites W2941917665 @default.
• W3087656522 cites W2942215178 @default.
• W3087656522 cites W2946242397 @default.
• W3087656522 cites W2980858589 @default.
• W3087656522 cites W2999304916 @default.
• W3087656522 cites W3011504450 @default.
• W3087656522 cites W3013600101 @default.
• W3087656522 cites W4211228754 @default.
• W3087656522 cites W4233777048 @default.
• W3087656522 cites W4243991213 @default.
• W3087656522 doi "https://doi.org/10.1136/jitc-2019-000406" @default.
• W3087656522 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7507895" @default.
• W3087656522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32958683" @default.
• W3087656522 hasPublicationYear "2020" @default.
• W3087656522 type Work @default.
• W3087656522 sameAs 3087656522 @default.
• W3087656522 citedByCount "22" @default.
• W3087656522 countsByYear W30876565222021 @default.
• W3087656522 countsByYear W30876565222022 @default.
• W3087656522 countsByYear W30876565222023 @default.
• W3087656522 crossrefType "journal-article" @default.
• W3087656522 hasAuthorship W3087656522A5004040364 @default.
• W3087656522 hasAuthorship W3087656522A5009606065 @default.
• W3087656522 hasAuthorship W3087656522A5017214879 @default.
• W3087656522 hasAuthorship W3087656522A5019429833 @default.
• W3087656522 hasAuthorship W3087656522A5041123392 @default.
• W3087656522 hasAuthorship W3087656522A5053275663 @default.
• W3087656522 hasAuthorship W3087656522A5074160443 @default.
• W3087656522 hasAuthorship W3087656522A5075546886 @default.
• W3087656522 hasAuthorship W3087656522A5076413653 @default.
• W3087656522 hasAuthorship W3087656522A5078512784 @default.
• W3087656522 hasAuthorship W3087656522A5090168066 @default.
• W3087656522 hasAuthorship W3087656522A5090533727 @default.
• W3087656522 hasAuthorship W3087656522A5091298949 @default.
• W3087656522 hasBestOaLocation W30876565221 @default.
• W3087656522 hasConcept C10515644 @default.
• W3087656522 hasConcept C121608353 @default.
• W3087656522 hasConcept C126322002 @default.
• W3087656522 hasConcept C134018914 @default.
• W3087656522 hasConcept C142724271 @default.
• W3087656522 hasConcept C143998085 @default.
• W3087656522 hasConcept C170493617 @default.
• W3087656522 hasConcept C204232928 @default.
• W3087656522 hasConcept C2777047896 @default.
• W3087656522 hasConcept C2777701055 @default.
• W3087656522 hasConcept C2781053074 @default.
• W3087656522 hasConcept C50382708 @default.
• W3087656522 hasConcept C63363279 @default.
• W3087656522 hasConcept C71924100 @default.
• W3087656522 hasConcept C72563966 @default.
• W3087656522 hasConcept C90924648 @default.
• W3087656522 hasConceptScore W3087656522C10515644 @default.
• W3087656522 hasConceptScore W3087656522C121608353 @default.

• next