Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087665932> ?p ?o ?g. }
- W3087665932 endingPage "2949" @default.
- W3087665932 startingPage "2940" @default.
- W3087665932 abstract "In a continuing search for potential inhibitors against human carboxylesterases 1A1 and 2A1 (hCES1A1 and hCES2A1), an EtOAc extract of the roots of Paeonia lactiflora showed strong hCES inhibition activity. Bioassay-guided fractionation led to the isolation of 26 terpenoids including 12 new ones (1–5, 7–12, and 26). Among these, sesquiterpenoids 1 and 6, monoterpenoids 10, 11, and 13–15, and triterpenoids 18–20, 22, and 24–26 contributed to the hCES2A1 inhibition, in the IC50 range of 1.9–14.5 μM, while the pentacyclic triterpenoids 18–26 were responsible for the potent inhibitory activity against hCES1A1, with IC50 values less than 5.0 μM. The structures of all the compounds were elucidated using MS and 1D and 2D NMR data, and the absolute configurations of the new compounds were resolved via specific rotation, experimental and calculated ECD spectra, and single-crystal X-ray diffraction analysis. The structure–activity relationship analysis highlighted that the free HO-3 group in the pentacyclic triterpenoids is crucial for their potent inhibitory activity against hCES1A1." @default.
- W3087665932 created "2020-09-25" @default.
- W3087665932 creator A5002490161 @default.
- W3087665932 creator A5043073852 @default.
- W3087665932 creator A5049459334 @default.
- W3087665932 creator A5056195164 @default.
- W3087665932 creator A5063216264 @default.
- W3087665932 creator A5072621212 @default.
- W3087665932 creator A5088680050 @default.
- W3087665932 creator A5089846519 @default.
- W3087665932 date "2020-09-21" @default.
- W3087665932 modified "2023-10-15" @default.
- W3087665932 title "Bioactivity-Guided Discovery of Human Carboxylesterase Inhibitors from the Roots of <i>Paeonia lactiflora</i>" @default.
- W3087665932 cites W1855949869 @default.
- W3087665932 cites W1945098908 @default.
- W3087665932 cites W1970872077 @default.
- W3087665932 cites W1989543622 @default.
- W3087665932 cites W1996095828 @default.
- W3087665932 cites W2001429802 @default.
- W3087665932 cites W2002005058 @default.
- W3087665932 cites W2006475517 @default.
- W3087665932 cites W2007648291 @default.
- W3087665932 cites W2011724151 @default.
- W3087665932 cites W2013636869 @default.
- W3087665932 cites W2025049476 @default.
- W3087665932 cites W2026588863 @default.
- W3087665932 cites W2042844942 @default.
- W3087665932 cites W2053175558 @default.
- W3087665932 cites W2063529880 @default.
- W3087665932 cites W2066778593 @default.
- W3087665932 cites W2092736436 @default.
- W3087665932 cites W2093896299 @default.
- W3087665932 cites W2098870463 @default.
- W3087665932 cites W2170156136 @default.
- W3087665932 cites W2322016009 @default.
- W3087665932 cites W2331010997 @default.
- W3087665932 cites W2414279676 @default.
- W3087665932 cites W2528122878 @default.
- W3087665932 cites W2557800206 @default.
- W3087665932 cites W2569994165 @default.
- W3087665932 cites W2581780524 @default.
- W3087665932 cites W2653602624 @default.
- W3087665932 cites W2772017860 @default.
- W3087665932 cites W2782729957 @default.
- W3087665932 cites W2799413702 @default.
- W3087665932 cites W2810653208 @default.
- W3087665932 cites W2950061157 @default.
- W3087665932 cites W2951957510 @default.
- W3087665932 cites W2995049970 @default.
- W3087665932 cites W2995654812 @default.
- W3087665932 cites W3004491662 @default.
- W3087665932 cites W3005716447 @default.
- W3087665932 doi "https://doi.org/10.1021/acs.jnatprod.0c00464" @default.
- W3087665932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32951423" @default.
- W3087665932 hasPublicationYear "2020" @default.
- W3087665932 type Work @default.
- W3087665932 sameAs 3087665932 @default.
- W3087665932 citedByCount "7" @default.
- W3087665932 countsByYear W30876659322021 @default.
- W3087665932 countsByYear W30876659322022 @default.
- W3087665932 countsByYear W30876659322023 @default.
- W3087665932 crossrefType "journal-article" @default.
- W3087665932 hasAuthorship W3087665932A5002490161 @default.
- W3087665932 hasAuthorship W3087665932A5043073852 @default.
- W3087665932 hasAuthorship W3087665932A5049459334 @default.
- W3087665932 hasAuthorship W3087665932A5056195164 @default.
- W3087665932 hasAuthorship W3087665932A5063216264 @default.
- W3087665932 hasAuthorship W3087665932A5072621212 @default.
- W3087665932 hasAuthorship W3087665932A5088680050 @default.
- W3087665932 hasAuthorship W3087665932A5089846519 @default.
- W3087665932 hasConcept C116073593 @default.
- W3087665932 hasConcept C142724271 @default.
- W3087665932 hasConcept C185592680 @default.
- W3087665932 hasConcept C19549132 @default.
- W3087665932 hasConcept C202751555 @default.
- W3087665932 hasConcept C204787440 @default.
- W3087665932 hasConcept C206103511 @default.
- W3087665932 hasConcept C2776710815 @default.
- W3087665932 hasConcept C2778913362 @default.
- W3087665932 hasConcept C2780527577 @default.
- W3087665932 hasConcept C44937612 @default.
- W3087665932 hasConcept C55493867 @default.
- W3087665932 hasConcept C71240020 @default.
- W3087665932 hasConcept C71924100 @default.
- W3087665932 hasConceptScore W3087665932C116073593 @default.
- W3087665932 hasConceptScore W3087665932C142724271 @default.
- W3087665932 hasConceptScore W3087665932C185592680 @default.
- W3087665932 hasConceptScore W3087665932C19549132 @default.
- W3087665932 hasConceptScore W3087665932C202751555 @default.
- W3087665932 hasConceptScore W3087665932C204787440 @default.
- W3087665932 hasConceptScore W3087665932C206103511 @default.
- W3087665932 hasConceptScore W3087665932C2776710815 @default.
- W3087665932 hasConceptScore W3087665932C2778913362 @default.
- W3087665932 hasConceptScore W3087665932C2780527577 @default.
- W3087665932 hasConceptScore W3087665932C44937612 @default.
- W3087665932 hasConceptScore W3087665932C55493867 @default.
- W3087665932 hasConceptScore W3087665932C71240020 @default.
- W3087665932 hasConceptScore W3087665932C71924100 @default.