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• W3087671657 endingPage "182" @default.
• W3087671657 startingPage "182" @default.
• W3087671657 abstract "Human fungal pathogens often encounter fungicidal stress upon host invasion, but they can swiftly adapt by transcriptional reprogramming that enables pathogen survival. Fungal immune evasion is tightly connected to chromatin regulation. Hence, fungal chromatin modifiers pose alternative treatment options to combat fungal infections. Here, we present an assay for transposase-accessible chromatin using sequencing (ATAC-seq) protocol adapted for the opportunistic pathogen Candida albicans to gain further insight into the interplay of chromatin accessibility and gene expression mounted during fungal adaptation to oxidative stress. The ATAC-seq workflow not only facilitates the robust detection of genomic regions with accessible chromatin but also allows for the precise modeling of nucleosome positions in C. albicans. Importantly, the data reveal genes with altered chromatin accessibility in upstream regulatory regions, which correlate with transcriptional regulation during oxidative stress. Interestingly, many genes show increased chromatin accessibility without change in gene expression upon stress exposure. Such chromatin signatures could predict yet unknown regulatory factors under highly dynamic transcriptional control. Additionally, de novo motif analysis in genomic regions with increased chromatin accessibility upon H2O2 treatment shows significant enrichment for Cap1 binding sites, a major factor of oxidative stress responses in C. albicans. Taken together, the ATAC-seq workflow enables the identification of chromatin signatures and highlights the dynamics of regulatory mechanisms mediating environmental adaptation of C. albicans." @default.
• W3087671657 created "2020-09-25" @default.
• W3087671657 creator A5004290346 @default.
• W3087671657 creator A5016873011 @default.
• W3087671657 creator A5018410383 @default.
• W3087671657 creator A5046539939 @default.
• W3087671657 date "2020-09-21" @default.
• W3087671657 modified "2023-10-09" @default.
• W3087671657 title "ATAC-Seq Identifies Chromatin Landscapes Linked to the Regulation of Oxidative Stress in the Human Fungal Pathogen Candida albicans" @default.
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• W3087671657 doi "https://doi.org/10.3390/jof6030182" @default.
• W3087671657 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7559329" @default.

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