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- W3087672172 abstract "Delirium is a syndrome characterized by acute brain failure resulting in neurocognitive disturbances affecting attention, awareness, and cognition. It is highly prevalent among critically ill patients and is associated with increased morbidity and mortality. A core domain of delirium is represented by behavioral disturbances in sleep-wake cycle probably related to circadian rhythm disruption. The relationship between sleep, circadian rhythm and intensive care unit (ICU)-acquired delirium is complex and likely bidirectional. In this review, we explore the proposed pathophysiological mechanisms of sleep disruption and circadian dysrhythmia as possible contributing factors in transitioning to delirium in the ICU and highlight some of the most relevant caveats for understanding the relationship between these complex phenomena. Specifically, we will (1) review the physiological consequences of poor sleep quality and efficiency; (2) explore how the neural substrate underlying the circadian clock functions may be disrupted in delirium; (3) discuss the role of sedative drugs as contributors to delirium and chrono-disruption; and, (4) describe the association between abnormal sleep-pathological wakefulness, circadian dysrhythmia, delirium and critical illness. Opportunities to improve sleep and readjust circadian rhythmicity to realign the circadian clock may exist as therapeutic targets in both the prevention and treatment of delirium in the ICU. Further research is required to better define these conditions and understand the underlying physiologic relationship to develop effective prevention and therapeutic strategies." @default.
- W3087672172 created "2020-09-25" @default.
- W3087672172 creator A5020449907 @default.
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- W3087672172 creator A5036877502 @default.
- W3087672172 creator A5062306514 @default.
- W3087672172 creator A5082185641 @default.
- W3087672172 date "2020-09-18" @default.
- W3087672172 modified "2023-10-10" @default.
- W3087672172 title "Abnormal Sleep, Circadian Rhythm Disruption, and Delirium in the ICU: Are They Related?" @default.
- W3087672172 cites W1488974332 @default.
- W3087672172 cites W1491094168 @default.
- W3087672172 cites W1556267441 @default.
- W3087672172 cites W1973706152 @default.
- W3087672172 cites W1975797644 @default.
- W3087672172 cites W1976673986 @default.
- W3087672172 cites W1977711623 @default.
- W3087672172 cites W1978965816 @default.
- W3087672172 cites W1981435384 @default.
- W3087672172 cites W1981836382 @default.
- W3087672172 cites W1983474575 @default.
- W3087672172 cites W1984524952 @default.
- W3087672172 cites W1994384365 @default.
- W3087672172 cites W1995972463 @default.
- W3087672172 cites W2006577184 @default.
- W3087672172 cites W2011960741 @default.
- W3087672172 cites W2012677452 @default.
- W3087672172 cites W2014238635 @default.
- W3087672172 cites W2017608370 @default.
- W3087672172 cites W2019379984 @default.
- W3087672172 cites W2020829878 @default.
- W3087672172 cites W2022002113 @default.
- W3087672172 cites W2022326132 @default.
- W3087672172 cites W2022599471 @default.
- W3087672172 cites W2028429075 @default.
- W3087672172 cites W2040415650 @default.
- W3087672172 cites W2044727916 @default.
- W3087672172 cites W2047282951 @default.
- W3087672172 cites W2058450217 @default.
- W3087672172 cites W2069022962 @default.
- W3087672172 cites W2073196382 @default.
- W3087672172 cites W2073875901 @default.
- W3087672172 cites W2082311304 @default.
- W3087672172 cites W2082409982 @default.
- W3087672172 cites W2087085939 @default.
- W3087672172 cites W2088951207 @default.
- W3087672172 cites W2094761105 @default.
- W3087672172 cites W2095527556 @default.
- W3087672172 cites W2100322905 @default.
- W3087672172 cites W2107632000 @default.
- W3087672172 cites W2111613011 @default.
- W3087672172 cites W2112787900 @default.
- W3087672172 cites W2126204966 @default.
- W3087672172 cites W2126787863 @default.
- W3087672172 cites W2130271602 @default.
- W3087672172 cites W2135672238 @default.
- W3087672172 cites W2144829518 @default.
- W3087672172 cites W2145859699 @default.
- W3087672172 cites W2146233711 @default.
- W3087672172 cites W2147313917 @default.
- W3087672172 cites W2147364251 @default.
- W3087672172 cites W2155622676 @default.
- W3087672172 cites W2158946857 @default.
- W3087672172 cites W2159784527 @default.
- W3087672172 cites W2163420132 @default.
- W3087672172 cites W2164824098 @default.
- W3087672172 cites W2178589601 @default.
- W3087672172 cites W2183269475 @default.
- W3087672172 cites W2236052756 @default.
- W3087672172 cites W2301769892 @default.
- W3087672172 cites W2330320745 @default.
- W3087672172 cites W2338789749 @default.
- W3087672172 cites W2342243277 @default.
- W3087672172 cites W2346602317 @default.
- W3087672172 cites W2468972555 @default.
- W3087672172 cites W2512525260 @default.
- W3087672172 cites W2521371801 @default.
- W3087672172 cites W2569417094 @default.
- W3087672172 cites W2586478317 @default.
- W3087672172 cites W2593459947 @default.
- W3087672172 cites W2599810930 @default.
- W3087672172 cites W2605324106 @default.
- W3087672172 cites W2611988532 @default.
- W3087672172 cites W2754147990 @default.
- W3087672172 cites W2776604856 @default.
- W3087672172 cites W2789428095 @default.
- W3087672172 cites W2789602753 @default.
- W3087672172 cites W2792551132 @default.
- W3087672172 cites W2806201669 @default.
- W3087672172 cites W2809044807 @default.
- W3087672172 cites W2885896746 @default.
- W3087672172 cites W2886033986 @default.
- W3087672172 cites W2893646816 @default.
- W3087672172 cites W2894823415 @default.
- W3087672172 cites W2920333616 @default.
- W3087672172 cites W2924639884 @default.
- W3087672172 cites W2969971968 @default.
- W3087672172 cites W2980809634 @default.
- W3087672172 cites W2980962832 @default.
- W3087672172 cites W2994312058 @default.