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• W3087680657 abstract "Proteins involved in the spaciotemporal regulation of GLUT4 trafficking represent potential therapeutic targets for the treatment of insulin resistance and type 2 diabetes. A key regulator of insulin- and exercise-stimulated glucose uptake and GLUT4 trafficking is TBC1D1. This study aimed to identify proteins that regulate GLUT4 trafficking and homeostasis via TBC1D1. Using an unbiased quantitative proteomics approach, we identified proteins that interact with TBC1D1 in C2C12 myotubes including VPS13A and VPS13C, the Rab binding proteins EHBP1L1 and MICAL1, and the calcium pump SERCA1. These proteins associate with TBC1D1 via its phosphotyrosine binding (PTB) domains and their interactions with TBC1D1 were unaffected by AMPK activation, distinguishing them from the AMPK regulated interaction between TBC1D1 and AMPKα1 complexes. Depletion of VPS13A or VPS13C caused a post-transcriptional increase in cellular GLUT4 protein and enhanced cell surface GLUT4 levels in response to AMPK activation. The phenomenon was specific to GLUT4 because other recycling proteins were unaffected. Our results provide further support for a role of the TBC1D1 PTB domains as a scaffold for a range of Rab regulators, and also the VPS13 family of proteins which have been previously linked to fasting glycaemic traits and insulin resistance in genome wide association studies." @default.
• W3087680657 created "2020-09-25" @default.
• W3087680657 creator A5017959452 @default.
• W3087680657 creator A5031087108 @default.
• W3087680657 creator A5034497460 @default.
• W3087680657 creator A5038362347 @default.
• W3087680657 creator A5043699942 @default.
• W3087680657 creator A5061020486 @default.
• W3087680657 creator A5064733533 @default.
• W3087680657 date "2020-10-21" @default.
• W3087680657 modified "2023-09-27" @default.
• W3087680657 title "TBC1D1 interacting proteins, VPS13A and VPS13C, regulate GLUT4 homeostasis in C2C12 myotubes" @default.
• W3087680657 cites W1517753349 @default.
• W3087680657 cites W1528723737 @default.
• W3087680657 cites W1537059497 @default.
• W3087680657 cites W1583005540 @default.
• W3087680657 cites W1596136472 @default.
• W3087680657 cites W1963848219 @default.
• W3087680657 cites W1965621126 @default.
• W3087680657 cites W1967821760 @default.
• W3087680657 cites W1973284660 @default.
• W3087680657 cites W1992233211 @default.
• W3087680657 cites W1994611191 @default.
• W3087680657 cites W1995353658 @default.
• W3087680657 cites W1997070642 @default.
• W3087680657 cites W1999720752 @default.
• W3087680657 cites W2000932082 @default.
• W3087680657 cites W2003991696 @default.
• W3087680657 cites W2009020864 @default.
• W3087680657 cites W2016455155 @default.
• W3087680657 cites W2024554906 @default.
• W3087680657 cites W2032026823 @default.
• W3087680657 cites W2038081709 @default.
• W3087680657 cites W2051702381 @default.
• W3087680657 cites W2051933513 @default.
• W3087680657 cites W2058860541 @default.
• W3087680657 cites W2063958537 @default.
• W3087680657 cites W2067803871 @default.
• W3087680657 cites W2074665385 @default.
• W3087680657 cites W2083580872 @default.
• W3087680657 cites W2085271514 @default.
• W3087680657 cites W2085692110 @default.
• W3087680657 cites W2086439115 @default.
• W3087680657 cites W2086500674 @default.
• W3087680657 cites W2094693414 @default.
• W3087680657 cites W2097210443 @default.
• W3087680657 cites W2101118920 @default.
• W3087680657 cites W2101990354 @default.
• W3087680657 cites W2105653570 @default.
• W3087680657 cites W2110219586 @default.
• W3087680657 cites W2115357041 @default.
• W3087680657 cites W2119748249 @default.
• W3087680657 cites W2119856031 @default.
• W3087680657 cites W2122953585 @default.
• W3087680657 cites W2123105928 @default.
• W3087680657 cites W2126090323 @default.
• W3087680657 cites W2126237420 @default.
• W3087680657 cites W2133470077 @default.
• W3087680657 cites W2136626081 @default.
• W3087680657 cites W2140442640 @default.
• W3087680657 cites W2141859364 @default.
• W3087680657 cites W2143902970 @default.
• W3087680657 cites W2145203464 @default.
• W3087680657 cites W2146213808 @default.
• W3087680657 cites W2147249344 @default.
• W3087680657 cites W2151339073 @default.
• W3087680657 cites W2151600164 @default.
• W3087680657 cites W2153554912 @default.
• W3087680657 cites W2153696855 @default.
• W3087680657 cites W2159422401 @default.
• W3087680657 cites W2164266826 @default.
• W3087680657 cites W2167698452 @default.
• W3087680657 cites W2171093928 @default.
• W3087680657 cites W2171750333 @default.
• W3087680657 cites W2181866290 @default.
• W3087680657 cites W2252412601 @default.
• W3087680657 cites W2252930819 @default.
• W3087680657 cites W2277100534 @default.
• W3087680657 cites W2292412857 @default.
• W3087680657 cites W2313579033 @default.
• W3087680657 cites W2329437993 @default.
• W3087680657 cites W2330505590 @default.
• W3087680657 cites W2434156456 @default.
• W3087680657 cites W2470281054 @default.
• W3087680657 cites W2531807162 @default.
• W3087680657 cites W2560140944 @default.
• W3087680657 cites W2606621683 @default.
• W3087680657 cites W2613232859 @default.
• W3087680657 cites W2750499077 @default.
• W3087680657 cites W2753690063 @default.
• W3087680657 cites W2754869062 @default.
• W3087680657 cites W2767694466 @default.
• W3087680657 cites W2790546752 @default.
• W3087680657 cites W2884390408 @default.
• W3087680657 cites W2885910759 @default.
• W3087680657 cites W2888538512 @default.
• W3087680657 cites W2895433806 @default.
• W3087680657 cites W2902365759 @default.
• W3087680657 cites W2911548071 @default.
• W3087680657 cites W2917079005 @default.

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