FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087687319> ?p ?o ?g. }

• W3087687319 endingPage "263" @default.
• W3087687319 startingPage "245" @default.
• W3087687319 abstract "Background: Cerebrospinal fluid (CSF) microRNA (miRNA) biomarkers of Alzheimer’s disease (AD) have been identified, but have not been evaluated in prodromal AD, including mild cognitive impairment (MCI). Objective: To assess whether a set of validated AD miRNA biomarkers in CSF are also sensitive to early-stage pathology as exemplified by MCI diagnosis. Methods: We measured the expression of 17 miRNA biomarkers for AD in CSF samples from AD, MCI, and cognitively normal controls (NC). We then examined classification performance of the miRNAs individually and in combination. For each miRNA, we assessed median expression in each diagnostic group and classified markers as trending linearly, nonlinearly, or lacking any trend across the three groups. For trending miRNAs, we assessed multimarker classification performance alone and in combination with apolipoprotein E ɛ4 allele (APOE ɛ4) genotype and amyloid-β42 to total tau ratio (Aβ42:T-Tau). We identified predicted targets of trending miRNAs using pathway analysis. Results: Five miRNAs showed a linear trend of decreasing median expression across the ordered diagnoses (control to MCI to AD). The trending miRNAs jointly predicted AD with area under the curve (AUC) of 0.770, and MCI with AUC of 0.705. Aβ42:T-Tau alone predicted MCI with AUC of 0.758 and the AUC improved to 0.813 (p = 0.051) after adding the trending miRNAs. Multivariate correlation of the five trending miRNAs with Aβ42:T-Tau was weak. Conclusion: Selected miRNAs combined with Aβ42:T-Tau improved classification performance (relative to protein biomarkers alone) for MCI, despite a weak correlation with Aβ42:T-Tau. Together these data suggest that that these miRNAs carry novel information relevant to AD, even at the MCI stage. Preliminary target prediction analysis suggests novel roles for these biomarkers." @default.
• W3087687319 created "2020-09-25" @default.
• W3087687319 creator A5008138486 @default.
• W3087687319 creator A5014611420 @default.
• W3087687319 creator A5024704957 @default.
• W3087687319 creator A5030130178 @default.
• W3087687319 creator A5039543650 @default.
• W3087687319 creator A5040775859 @default.
• W3087687319 creator A5049904624 @default.
• W3087687319 creator A5072592799 @default.
• W3087687319 creator A5085009648 @default.
• W3087687319 creator A5087439965 @default.
• W3087687319 creator A5088497772 @default.
• W3087687319 date "2020-10-27" @default.
• W3087687319 modified "2023-10-16" @default.
• W3087687319 title "Performance of Validated MicroRNA Biomarkers for Alzheimer’s Disease in Mild Cognitive Impairment" @default.
• W3087687319 cites W1487838396 @default.
• W3087687319 cites W1605551280 @default.
• W3087687319 cites W1735913208 @default.
• W3087687319 cites W1905297489 @default.
• W3087687319 cites W1912095687 @default.
• W3087687319 cites W1920972969 @default.
• W3087687319 cites W1996807233 @default.
• W3087687319 cites W2002385808 @default.
• W3087687319 cites W2007696560 @default.
• W3087687319 cites W2010643121 @default.
• W3087687319 cites W2014635051 @default.
• W3087687319 cites W2029085167 @default.
• W3087687319 cites W2052226124 @default.
• W3087687319 cites W2083381199 @default.
• W3087687319 cites W2093923054 @default.
• W3087687319 cites W2105071925 @default.
• W3087687319 cites W2111774300 @default.
• W3087687319 cites W2115017507 @default.
• W3087687319 cites W2127983258 @default.
• W3087687319 cites W2129497119 @default.
• W3087687319 cites W2134629862 @default.
• W3087687319 cites W2134975289 @default.
• W3087687319 cites W2156220037 @default.
• W3087687319 cites W2162674813 @default.
• W3087687319 cites W2517412327 @default.
• W3087687319 cites W2548823238 @default.
• W3087687319 cites W2559923253 @default.
• W3087687319 cites W2582524520 @default.
• W3087687319 cites W2586834816 @default.
• W3087687319 cites W2587485759 @default.
• W3087687319 cites W2614523924 @default.
• W3087687319 cites W2625896810 @default.
• W3087687319 cites W2734510557 @default.
• W3087687319 cites W2767546566 @default.
• W3087687319 cites W2770316150 @default.
• W3087687319 cites W2771168010 @default.
• W3087687319 cites W2780732598 @default.
• W3087687319 cites W2789457069 @default.
• W3087687319 cites W2789650455 @default.
• W3087687319 cites W2795207192 @default.
• W3087687319 cites W2801831966 @default.
• W3087687319 cites W2809499549 @default.
• W3087687319 cites W2884780489 @default.
• W3087687319 cites W2897379107 @default.
• W3087687319 cites W2911681407 @default.
• W3087687319 cites W2915433652 @default.
• W3087687319 cites W2963082003 @default.
• W3087687319 cites W2970358232 @default.
• W3087687319 cites W2972635775 @default.
• W3087687319 cites W32204808 @default.
• W3087687319 doi "https://doi.org/10.3233/jad-200396" @default.
• W3087687319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32955460" @default.
• W3087687319 hasPublicationYear "2020" @default.
• W3087687319 type Work @default.
• W3087687319 sameAs 3087687319 @default.
• W3087687319 citedByCount "4" @default.
• W3087687319 countsByYear W30876873192021 @default.
• W3087687319 countsByYear W30876873192022 @default.
• W3087687319 crossrefType "journal-article" @default.
• W3087687319 hasAuthorship W3087687319A5008138486 @default.
• W3087687319 hasAuthorship W3087687319A5014611420 @default.
• W3087687319 hasAuthorship W3087687319A5024704957 @default.
• W3087687319 hasAuthorship W3087687319A5030130178 @default.
• W3087687319 hasAuthorship W3087687319A5039543650 @default.
• W3087687319 hasAuthorship W3087687319A5040775859 @default.
• W3087687319 hasAuthorship W3087687319A5049904624 @default.
• W3087687319 hasAuthorship W3087687319A5072592799 @default.
• W3087687319 hasAuthorship W3087687319A5085009648 @default.
• W3087687319 hasAuthorship W3087687319A5087439965 @default.
• W3087687319 hasAuthorship W3087687319A5088497772 @default.
• W3087687319 hasBestOaLocation W30876873192 @default.
• W3087687319 hasConcept C104317684 @default.
• W3087687319 hasConcept C126322002 @default.
• W3087687319 hasConcept C143998085 @default.
• W3087687319 hasConcept C145059251 @default.
• W3087687319 hasConcept C146357865 @default.
• W3087687319 hasConcept C151730666 @default.
• W3087687319 hasConcept C2779134260 @default.
• W3087687319 hasConcept C2781197716 @default.
• W3087687319 hasConcept C2984915365 @default.
• W3087687319 hasConcept C3017616150 @default.
• W3087687319 hasConcept C3020132585 @default.

• next