FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087688857> ?p ?o ?g. }

• W3087688857 abstract "Previous study has identified Ziyu II as a potent anti-tumor agent, but limited data on the efficacy and potential mechanism of Ziyu II in the treatment of CRC. In this study, Ziyu II exhibits antitumor activity against CRC cells both in vitro and in vivo. It demonstrated that treatment with Ziyu II induced apoptosis via accumulation of reactive oxygen species (ROS). Intriguingly, Ziyu II treatment triggered complete autophagic flux in CRC cells. Inhibition of autophagy partially reversed Ziyu II-induced growth inhibition in CRC cells, suggesting a cytotoxic role of Ziyu II-induced autophagy. Mechanistic studies showed that Ziyu II induced autophagy by inhibiting Akt/mTOR pathway, and Akt reactivation partially reduced Ziyu II-induced autophagy. Notably, Ziyu II improves the sensitivity of CRC cells to the first-line chemotherapeutic drugs 5-fluorouracil. This study provides new insights into the molecular mechanisms of Ziyu II-mediated CRC suppression involving induction of both apoptosis and autophagy, and establishes potential applications of Ziyu II for clinical CRC treatment." @default.
• W3087688857 created "2020-09-25" @default.
• W3087688857 creator A5014943822 @default.
• W3087688857 creator A5044102799 @default.
• W3087688857 creator A5044808423 @default.
• W3087688857 creator A5053586953 @default.
• W3087688857 creator A5087859400 @default.
• W3087688857 creator A5091885695 @default.
• W3087688857 date "2020-09-18" @default.
• W3087688857 modified "2023-10-02" @default.
• W3087688857 title "Repurposing Ziyuglycoside II Against Colorectal Cancer via Orchestrating Apoptosis and Autophagy" @default.
• W3087688857 cites W2012856926 @default.
• W3087688857 cites W2024889845 @default.
• W3087688857 cites W2034786597 @default.
• W3087688857 cites W2044389093 @default.
• W3087688857 cites W2052419480 @default.
• W3087688857 cites W2075290185 @default.
• W3087688857 cites W2080116307 @default.
• W3087688857 cites W2140912399 @default.
• W3087688857 cites W2147293632 @default.
• W3087688857 cites W2149270714 @default.
• W3087688857 cites W2426965800 @default.
• W3087688857 cites W2476132284 @default.
• W3087688857 cites W2489207582 @default.
• W3087688857 cites W2551179784 @default.
• W3087688857 cites W2588451433 @default.
• W3087688857 cites W2592649907 @default.
• W3087688857 cites W2594373254 @default.
• W3087688857 cites W2601754404 @default.
• W3087688857 cites W2604527271 @default.
• W3087688857 cites W2607112478 @default.
• W3087688857 cites W2611224317 @default.
• W3087688857 cites W2617642067 @default.
• W3087688857 cites W2626025027 @default.
• W3087688857 cites W2725933288 @default.
• W3087688857 cites W2737828313 @default.
• W3087688857 cites W2770940099 @default.
• W3087688857 cites W2789397582 @default.
• W3087688857 cites W2799473901 @default.
• W3087688857 cites W2883036698 @default.
• W3087688857 cites W2889646458 @default.
• W3087688857 cites W2895302001 @default.
• W3087688857 cites W2896002881 @default.
• W3087688857 cites W2897995161 @default.
• W3087688857 cites W2901014197 @default.
• W3087688857 cites W2908666122 @default.
• W3087688857 cites W2913389688 @default.
• W3087688857 cites W2928431398 @default.
• W3087688857 cites W2940098492 @default.
• W3087688857 cites W2958926637 @default.
• W3087688857 cites W2982127187 @default.
• W3087688857 cites W3158292791 @default.
• W3087688857 cites W4211001330 @default.
• W3087688857 doi "https://doi.org/10.3389/fphar.2020.576547" @default.
• W3087688857 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7533566" @default.
• W3087688857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33071789" @default.
• W3087688857 hasPublicationYear "2020" @default.
• W3087688857 type Work @default.
• W3087688857 sameAs 3087688857 @default.
• W3087688857 citedByCount "11" @default.
• W3087688857 countsByYear W30876888572021 @default.
• W3087688857 countsByYear W30876888572022 @default.
• W3087688857 countsByYear W30876888572023 @default.
• W3087688857 crossrefType "journal-article" @default.
• W3087688857 hasAuthorship W3087688857A5014943822 @default.
• W3087688857 hasAuthorship W3087688857A5044102799 @default.
• W3087688857 hasAuthorship W3087688857A5044808423 @default.
• W3087688857 hasAuthorship W3087688857A5053586953 @default.
• W3087688857 hasAuthorship W3087688857A5087859400 @default.
• W3087688857 hasAuthorship W3087688857A5091885695 @default.
• W3087688857 hasBestOaLocation W30876888571 @default.
• W3087688857 hasConcept C121608353 @default.
• W3087688857 hasConcept C150903083 @default.
• W3087688857 hasConcept C154317977 @default.
• W3087688857 hasConcept C185592680 @default.
• W3087688857 hasConcept C190283241 @default.
• W3087688857 hasConcept C202751555 @default.
• W3087688857 hasConcept C203522944 @default.
• W3087688857 hasConcept C207001950 @default.
• W3087688857 hasConcept C48349386 @default.
• W3087688857 hasConcept C502942594 @default.
• W3087688857 hasConcept C526805850 @default.
• W3087688857 hasConcept C54355233 @default.
• W3087688857 hasConcept C55493867 @default.
• W3087688857 hasConcept C75217442 @default.
• W3087688857 hasConcept C81885089 @default.
• W3087688857 hasConcept C86554907 @default.
• W3087688857 hasConcept C86803240 @default.
• W3087688857 hasConcept C95444343 @default.
• W3087688857 hasConceptScore W3087688857C121608353 @default.
• W3087688857 hasConceptScore W3087688857C150903083 @default.
• W3087688857 hasConceptScore W3087688857C154317977 @default.
• W3087688857 hasConceptScore W3087688857C185592680 @default.
• W3087688857 hasConceptScore W3087688857C190283241 @default.
• W3087688857 hasConceptScore W3087688857C202751555 @default.
• W3087688857 hasConceptScore W3087688857C203522944 @default.
• W3087688857 hasConceptScore W3087688857C207001950 @default.
• W3087688857 hasConceptScore W3087688857C48349386 @default.
• W3087688857 hasConceptScore W3087688857C502942594 @default.
• W3087688857 hasConceptScore W3087688857C526805850 @default.

• next