Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087714301> ?p ?o ?g. }
- W3087714301 abstract "Early adversity is a risk factor for the development of adult psychopathology. Common across multiple rodent models of early adversity is increased signaling via forebrain Gq-coupled neurotransmitter receptors. We addressed whether enhanced Gq-mediated signaling in forebrain excitatory neurons during postnatal life can evoke persistent mood-related behavioral changes. Excitatory hM3Dq DREADD-mediated chemogenetic activation of forebrain excitatory neurons during postnatal life (P2–14), but not in juvenile or adult windows, increased anxiety-, despair-, and schizophrenia-like behavior in adulthood. This was accompanied by an enhanced metabolic rate of cortical and hippocampal glutamatergic and GABAergic neurons. Furthermore, we observed reduced activity and plasticity-associated marker expression, and perturbed excitatory/inhibitory currents in the hippocampus. These results indicate that Gq-signaling-mediated activation of forebrain excitatory neurons during the critical postnatal window is sufficient to program altered mood-related behavior, as well as functional changes in forebrain glutamate and GABA systems, recapitulating aspects of the consequences of early adversity." @default.
- W3087714301 created "2020-09-25" @default.
- W3087714301 creator A5008766466 @default.
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- W3087714301 date "2020-09-21" @default.
- W3087714301 modified "2023-10-17" @default.
- W3087714301 title "Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior" @default.
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