FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087719424> ?p ?o ?g. }

• W3087719424 endingPage "7854" @default.
• W3087719424 startingPage "7837" @default.
• W3087719424 abstract "As one of the thalamic midline nuclei, the thalamic paraventricular nucleus (PVT) is considered to be an important signal integration site for many descending and ascending pathways that modulate a variety of behaviors, including feeding, emotions, and drug-seeking. A recent study has demonstrated that the PVT is implicated in the acute visceral pain response, but it is unclear whether the PVT plays a critical role in the central processing of chronic pain. Here, we report that the neurons in the posterior portion of the PVT (pPVT) and their downstream pathway are involved in descending nociceptive facilitation regarding the development of neuropathic pain conditions in male rats. Lesions or inhibition of pPVT neurons alleviated mechanical allodynia induced by spared nerve injury (SNI). The excitability of pPVT-central amygdala (CeA) projection neurons was significantly increased in SNI rats. Importantly, selective optogenetic activation of the pPVT-CeA pathway induced obvious mechanical hypersensitivity in naive rats. In addition, we used rabies virus (RV)-based and cell-type-specific retrograde transsynaptic tracing techniques to define a novel neuronal circuit in which glutamatergic neurons in the vlPAG were the target of the pPVT-CeA descending facilitation pathway. Our data suggest that this pPVT Glu+ -CeA-vlPAG Glu+ circuit mediates central mechanisms of descending pain facilitation underlying persistent pain conditions. SIGNIFICANCE STATEMENT Studies have shown that the interactions between the posterior portion of the thalamic paraventricular nucleus (pPVT) and central amygdala (CeA) play a critical role in pain-related emotional regulation. However, most reports have associated this circuit with fear and anxiety behaviors. Here, an integrative approach of behavioral tests, electrophysiology, and immunohistochemistry was used to advance the novel concept that the pPVT-CeA pathway activation facilitates neuropathic pain processing. Using rabies virus (RV)-based and cell-type-specific retrograde transsynaptic tracing techniques, we found that glutamatergic neurons in the vlPAG were the target of the pPVT-CeA pathway. Thus, this study indicates the involvement of a pPVT Glu+ -CeA-vlPAG Glu+ pathway in a descending facilitatory mechanism underlying neuropathic pain." @default.
• W3087719424 created "2020-09-25" @default.
• W3087719424 creator A5005657798 @default.
• W3087719424 creator A5025384599 @default.
• W3087719424 creator A5028344363 @default.
• W3087719424 creator A5032764121 @default.
• W3087719424 creator A5035861923 @default.
• W3087719424 creator A5045859930 @default.
• W3087719424 creator A5058888901 @default.
• W3087719424 creator A5059254359 @default.
• W3087719424 creator A5075762469 @default.
• W3087719424 creator A5085469203 @default.
• W3087719424 date "2020-09-21" @default.
• W3087719424 modified "2023-10-18" @default.
• W3087719424 title "A Neural Circuit from Thalamic Paraventricular Nucleus to Central Amygdala for the Facilitation of Neuropathic Pain" @default.
• W3087719424 cites W1463791314 @default.
• W3087719424 cites W1521382255 @default.
• W3087719424 cites W1862521538 @default.
• W3087719424 cites W1963819476 @default.
• W3087719424 cites W1966403223 @default.
• W3087719424 cites W1968714114 @default.
• W3087719424 cites W1972768039 @default.
• W3087719424 cites W1983257841 @default.
• W3087719424 cites W1992384753 @default.
• W3087719424 cites W1994046434 @default.
• W3087719424 cites W1997369702 @default.
• W3087719424 cites W2003549933 @default.
• W3087719424 cites W2003617049 @default.
• W3087719424 cites W2004551214 @default.
• W3087719424 cites W2008106418 @default.
• W3087719424 cites W2012068152 @default.
• W3087719424 cites W2014731714 @default.
• W3087719424 cites W2015980149 @default.
• W3087719424 cites W2022297536 @default.
• W3087719424 cites W2029035945 @default.
• W3087719424 cites W2030155402 @default.
• W3087719424 cites W2034736385 @default.
• W3087719424 cites W2040847356 @default.
• W3087719424 cites W2046389491 @default.
• W3087719424 cites W2047010161 @default.
• W3087719424 cites W2047376385 @default.
• W3087719424 cites W2049678062 @default.
• W3087719424 cites W2050251142 @default.
• W3087719424 cites W2050750919 @default.
• W3087719424 cites W2056240232 @default.
• W3087719424 cites W2056492757 @default.
• W3087719424 cites W2059635921 @default.
• W3087719424 cites W2062700118 @default.
• W3087719424 cites W2064896421 @default.
• W3087719424 cites W2066231624 @default.
• W3087719424 cites W2073775590 @default.
• W3087719424 cites W2083155159 @default.
• W3087719424 cites W2086714775 @default.
• W3087719424 cites W2087454739 @default.
• W3087719424 cites W2088688806 @default.
• W3087719424 cites W2089900318 @default.
• W3087719424 cites W2096879872 @default.
• W3087719424 cites W2098925781 @default.
• W3087719424 cites W2100693671 @default.
• W3087719424 cites W2101653246 @default.
• W3087719424 cites W2128823555 @default.
• W3087719424 cites W2130557233 @default.
• W3087719424 cites W2145062794 @default.
• W3087719424 cites W2145926148 @default.
• W3087719424 cites W2152069469 @default.
• W3087719424 cites W2154413133 @default.
• W3087719424 cites W2159259673 @default.
• W3087719424 cites W2162328280 @default.
• W3087719424 cites W2164826784 @default.
• W3087719424 cites W2170241325 @default.
• W3087719424 cites W2271643048 @default.
• W3087719424 cites W2296576025 @default.
• W3087719424 cites W2337538708 @default.
• W3087719424 cites W2399670039 @default.
• W3087719424 cites W2415217866 @default.
• W3087719424 cites W2471199430 @default.
• W3087719424 cites W2583553931 @default.
• W3087719424 cites W2616069238 @default.
• W3087719424 cites W2888414703 @default.
• W3087719424 cites W792393746 @default.
• W3087719424 doi "https://doi.org/10.1523/jneurosci.2487-19.2020" @default.
• W3087719424 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7548696" @default.
• W3087719424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32958568" @default.
• W3087719424 hasPublicationYear "2020" @default.
• W3087719424 type Work @default.
• W3087719424 sameAs 3087719424 @default.
• W3087719424 citedByCount "38" @default.
• W3087719424 countsByYear W30877194242021 @default.
• W3087719424 countsByYear W30877194242022 @default.
• W3087719424 countsByYear W30877194242023 @default.
• W3087719424 crossrefType "journal-article" @default.
• W3087719424 hasAuthorship W3087719424A5005657798 @default.
• W3087719424 hasAuthorship W3087719424A5025384599 @default.
• W3087719424 hasAuthorship W3087719424A5028344363 @default.
• W3087719424 hasAuthorship W3087719424A5032764121 @default.
• W3087719424 hasAuthorship W3087719424A5035861923 @default.
• W3087719424 hasAuthorship W3087719424A5045859930 @default.
• W3087719424 hasAuthorship W3087719424A5058888901 @default.

• next