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- W3087719639 abstract "The cytotoxic T-lymphocyte antigen-4 (CTLA-4) pathway acts as a negative immune regulator of T-cell activation and promotes self-tolerance.We report the first case of biopsy-proven central nervous system inflammatory demyelination in the context of primary immunodeficiency and a novel CTLA-4 variant.This case has significant implications for the development of novel treatments for autoimmune conditions including multiple sclerosis and further emphasises the need for caution with clinical use of CTLA-4 immune checkpoint inhibitors in those with a history of inflammatory demyelination." @default.
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- W3087719639 date "2021-06-07" @default.
- W3087719639 modified "2023-09-27" @default.
- W3087719639 title "CNS demyelination associated with immune dysregulation and a novel CTLA-4 variant" @default.
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- W3087719639 doi "https://doi.org/10.1177/1352458520963896" @default.
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