FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087735823> ?p ?o ?g. }

• W3087735823 endingPage "3009" @default.
• W3087735823 startingPage "3001" @default.
• W3087735823 abstract "Abstract Background Individuals with hereditary hemochromatosis (HH) receive frequent blood withdrawals (ie, venesections) as part of their primary treatment to assist in normalizing blood iron levels. It remains unclear whether this source of blood is suitable for use in blood product development, as current data indicate that red blood cell (RBC) deformability, both before and after shear stress exposure, is impaired in individuals with HH, relative to healthy controls. Given that venesection therapy is known to significantly reduce circulating iron levels in individuals with HH, the current study examined whether venesection therapy is effective at improving RBC mechanical properties, both before and after shear stress exposure, in individuals with HH. Study Design and Methods Blood samples were initially collected from untreated HH patients (age, 61 ± 9 years; 14% female) undergoing their first venesection, and then again during their second (approx. 9 weeks later) and third (approx. 16 weeks later) venesections. RBC deformability was measured at each time point with a commercial ektacytometer. Moreover, to determine cell responses to mechanical stimuli, the mechanical sensitivity of blood samples was determined at each time point. Results The salient findings indicate that venesection therapy used for managing plasma ferritin concentration significantly improves the cellular deformability of RBC in individuals with HH. Further, the sensitivity of RBC to supraphysiological mechanical stress is decreased (ie, improved) in a dose‐response fashion with routine venesection. Conclusion While cellular mechanics of RBC from individuals with HH are impaired when untreated, venesection therapy significantly improves cellular properties of RBC, supporting the use of venesections in blood product development from individuals with well‐managed HH." @default.
• W3087735823 created "2020-09-25" @default.
• W3087735823 creator A5014369845 @default.
• W3087735823 creator A5026610040 @default.
• W3087735823 creator A5049560493 @default.
• W3087735823 date "2020-09-17" @default.
• W3087735823 modified "2023-09-26" @default.
• W3087735823 title "Mechanical sensitivity of red blood cells improves in individuals with hemochromatosis following venesection therapy" @default.
• W3087735823 cites W1597550155 @default.
• W3087735823 cites W1957052033 @default.
• W3087735823 cites W1964787909 @default.
• W3087735823 cites W1979923361 @default.
• W3087735823 cites W1993466365 @default.
• W3087735823 cites W2016394352 @default.
• W3087735823 cites W2026774674 @default.
• W3087735823 cites W2046829645 @default.
• W3087735823 cites W2048706423 @default.
• W3087735823 cites W2052023508 @default.
• W3087735823 cites W2084282023 @default.
• W3087735823 cites W2097654356 @default.
• W3087735823 cites W2103433121 @default.
• W3087735823 cites W2107504607 @default.
• W3087735823 cites W2109973294 @default.
• W3087735823 cites W2152429066 @default.
• W3087735823 cites W2155381328 @default.
• W3087735823 cites W2178608565 @default.
• W3087735823 cites W2226956563 @default.
• W3087735823 cites W2305251701 @default.
• W3087735823 cites W2346503820 @default.
• W3087735823 cites W2411250814 @default.
• W3087735823 cites W2521366834 @default.
• W3087735823 cites W2548255891 @default.
• W3087735823 cites W2558688385 @default.
• W3087735823 cites W2586684442 @default.
• W3087735823 cites W2616808188 @default.
• W3087735823 cites W2751808077 @default.
• W3087735823 cites W2792287949 @default.
• W3087735823 cites W2796900727 @default.
• W3087735823 cites W2887007395 @default.
• W3087735823 cites W2896362348 @default.
• W3087735823 cites W2930677652 @default.
• W3087735823 cites W2995109242 @default.
• W3087735823 doi "https://doi.org/10.1111/trf.16080" @default.
• W3087735823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32939772" @default.
• W3087735823 hasPublicationYear "2020" @default.
• W3087735823 type Work @default.
• W3087735823 sameAs 3087735823 @default.
• W3087735823 citedByCount "1" @default.
• W3087735823 countsByYear W30877358232023 @default.
• W3087735823 crossrefType "journal-article" @default.
• W3087735823 hasAuthorship W3087735823A5014369845 @default.
• W3087735823 hasAuthorship W3087735823A5026610040 @default.
• W3087735823 hasAuthorship W3087735823A5049560493 @default.
• W3087735823 hasConcept C126322002 @default.
• W3087735823 hasConcept C2776557347 @default.
• W3087735823 hasConcept C2776590208 @default.
• W3087735823 hasConcept C2777357209 @default.
• W3087735823 hasConcept C2778917026 @default.
• W3087735823 hasConcept C2780959883 @default.
• W3087735823 hasConcept C3018783601 @default.
• W3087735823 hasConcept C42407357 @default.
• W3087735823 hasConcept C71924100 @default.
• W3087735823 hasConcept C90924648 @default.
• W3087735823 hasConceptScore W3087735823C126322002 @default.
• W3087735823 hasConceptScore W3087735823C2776557347 @default.
• W3087735823 hasConceptScore W3087735823C2776590208 @default.
• W3087735823 hasConceptScore W3087735823C2777357209 @default.
• W3087735823 hasConceptScore W3087735823C2778917026 @default.
• W3087735823 hasConceptScore W3087735823C2780959883 @default.
• W3087735823 hasConceptScore W3087735823C3018783601 @default.
• W3087735823 hasConceptScore W3087735823C42407357 @default.
• W3087735823 hasConceptScore W3087735823C71924100 @default.
• W3087735823 hasConceptScore W3087735823C90924648 @default.
• W3087735823 hasIssue "12" @default.
• W3087735823 hasLocation W30877358231 @default.
• W3087735823 hasOpenAccess W3087735823 @default.
• W3087735823 hasPrimaryLocation W30877358231 @default.
• W3087735823 hasRelatedWork W1895112193 @default.
• W3087735823 hasRelatedWork W1966181510 @default.
• W3087735823 hasRelatedWork W2052836594 @default.
• W3087735823 hasRelatedWork W2170450081 @default.
• W3087735823 hasRelatedWork W2404944273 @default.
• W3087735823 hasRelatedWork W2406544060 @default.
• W3087735823 hasRelatedWork W2513098452 @default.
• W3087735823 hasRelatedWork W2566019316 @default.
• W3087735823 hasRelatedWork W4238350606 @default.
• W3087735823 hasRelatedWork W75990048 @default.
• W3087735823 hasVolume "60" @default.
• W3087735823 isParatext "false" @default.
• W3087735823 isRetracted "false" @default.
• W3087735823 magId "3087735823" @default.
• W3087735823 workType "article" @default.