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- W3087738933 abstract "Abstract Background It is unclear whether depression is linked to nonalcoholic fatty liver disease (NAFLD). The purpose of this study was to examine the association between depression and NAFLD and whether the association is partly explained by insulin resistance or inflammation. Methods Subjects consisted of 4,688 adults who participated in the 2016 Korea National Health and Nutrition Examination Survey. Depression was defined by Patient Health Questionnaire-9 score ≥ 10 or a previous diagnosis of depression. NAFLD was defined by hepatic steatosis index >36. Insulin resistance was assessed by triglycerides and glucose (TyG) index. Inflammation was measured with C-reactive protein (CRP). Results Depression had a significant association with TyG index (p = 0.005), but not with CRP. Depression was a significant predictor of NAFLD (OR = 1.63; 95% CI, 1.26–2.10; p Limitations The absence of a structured diagnostic interview for depression and histological diagnosis of NAFLD. Conclusions These data support an association of depression with NAFLD. Insulin resistance seems to play a major role in modulating the association between depression and NAFLD risk." @default.
- W3087738933 created "2020-09-25" @default.
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- W3087738933 date "2021-01-01" @default.
- W3087738933 modified "2023-09-23" @default.
- W3087738933 title "Association between depression and nonalcoholic fatty liver disease: Contributions of insulin resistance and inflammation" @default.
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- W3087738933 doi "https://doi.org/10.1016/j.jad.2020.09.073" @default.
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