Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087754470> ?p ?o ?g. }
- W3087754470 endingPage "1251" @default.
- W3087754470 startingPage "1239" @default.
- W3087754470 abstract "The contribution of ribosome heterogeneity and ribosome-associated proteins to the molecular control of proteomes in health and disease remains unclear. Here, we demonstrate that survival motor neuron (SMN) protein-the loss of which causes the neuromuscular disease spinal muscular atrophy (SMA)-binds to ribosomes and that this interaction is tissue-dependent. SMN-primed ribosomes are preferentially positioned within the first five codons of a set of mRNAs that are enriched for translational enhancer sequences in the 5' untranslated region (UTR) and rare codons at the beginning of their coding sequence. These SMN-specific mRNAs are associated with neurogenesis, lipid metabolism, ubiquitination, chromatin regulation and translation. Loss of SMN induces ribosome depletion, especially at the beginning of the coding sequence of SMN-specific mRNAs, leading to impairment of proteins that are involved in motor neuron function and stability, including acetylcholinesterase. Thus, SMN plays a crucial role in the regulation of ribosome fluxes along mRNAs encoding proteins that are relevant to SMA pathogenesis." @default.
- W3087754470 created "2020-09-25" @default.
- W3087754470 creator A5002300255 @default.
- W3087754470 creator A5002934973 @default.
- W3087754470 creator A5016501395 @default.
- W3087754470 creator A5017062431 @default.
- W3087754470 creator A5026682469 @default.
- W3087754470 creator A5028629013 @default.
- W3087754470 creator A5034776035 @default.
- W3087754470 creator A5050472441 @default.
- W3087754470 creator A5054752160 @default.
- W3087754470 creator A5055362368 @default.
- W3087754470 creator A5056995428 @default.
- W3087754470 creator A5062391969 @default.
- W3087754470 creator A5065794329 @default.
- W3087754470 creator A5071937871 @default.
- W3087754470 creator A5074952586 @default.
- W3087754470 creator A5075560413 @default.
- W3087754470 creator A5080723488 @default.
- W3087754470 creator A5085732836 @default.
- W3087754470 date "2020-09-21" @default.
- W3087754470 modified "2023-10-10" @default.
- W3087754470 title "SMN-primed ribosomes modulate the translation of transcripts related to spinal muscular atrophy" @default.
- W3087754470 cites W1554872850 @default.
- W3087754470 cites W1805154234 @default.
- W3087754470 cites W1973854455 @default.
- W3087754470 cites W1980477780 @default.
- W3087754470 cites W1984680116 @default.
- W3087754470 cites W1987111650 @default.
- W3087754470 cites W1990393476 @default.
- W3087754470 cites W2006986579 @default.
- W3087754470 cites W2007030668 @default.
- W3087754470 cites W2021907284 @default.
- W3087754470 cites W2040885133 @default.
- W3087754470 cites W2047268435 @default.
- W3087754470 cites W2050163135 @default.
- W3087754470 cites W2052326665 @default.
- W3087754470 cites W2056032938 @default.
- W3087754470 cites W2066600362 @default.
- W3087754470 cites W2067177763 @default.
- W3087754470 cites W2068065584 @default.
- W3087754470 cites W2070413754 @default.
- W3087754470 cites W2082889233 @default.
- W3087754470 cites W2086157203 @default.
- W3087754470 cites W2104483488 @default.
- W3087754470 cites W2107257806 @default.
- W3087754470 cites W2108531896 @default.
- W3087754470 cites W2109273258 @default.
- W3087754470 cites W2112430789 @default.
- W3087754470 cites W2112515372 @default.
- W3087754470 cites W2116236963 @default.
- W3087754470 cites W2116831267 @default.
- W3087754470 cites W2119694662 @default.
- W3087754470 cites W2120949999 @default.
- W3087754470 cites W2122438081 @default.
- W3087754470 cites W2128551987 @default.
- W3087754470 cites W2131290038 @default.
- W3087754470 cites W2131651601 @default.
- W3087754470 cites W2139189662 @default.
- W3087754470 cites W2143443658 @default.
- W3087754470 cites W2144444443 @default.
- W3087754470 cites W2148071380 @default.
- W3087754470 cites W2153484644 @default.
- W3087754470 cites W2154357643 @default.
- W3087754470 cites W2159151202 @default.
- W3087754470 cites W2171323620 @default.
- W3087754470 cites W2177551914 @default.
- W3087754470 cites W2234324103 @default.
- W3087754470 cites W2329759634 @default.
- W3087754470 cites W2408947950 @default.
- W3087754470 cites W2511208856 @default.
- W3087754470 cites W2576909235 @default.
- W3087754470 cites W2605873159 @default.
- W3087754470 cites W2610457719 @default.
- W3087754470 cites W2625763766 @default.
- W3087754470 cites W2738059873 @default.
- W3087754470 cites W2741666038 @default.
- W3087754470 cites W2748301672 @default.
- W3087754470 cites W2765825678 @default.
- W3087754470 cites W2767992943 @default.
- W3087754470 cites W2770478930 @default.
- W3087754470 cites W2778932781 @default.
- W3087754470 cites W2787482106 @default.
- W3087754470 cites W2789689928 @default.
- W3087754470 cites W2791418880 @default.
- W3087754470 cites W2803950888 @default.
- W3087754470 cites W2809498556 @default.
- W3087754470 cites W2889147525 @default.
- W3087754470 cites W2894927071 @default.
- W3087754470 cites W2906559793 @default.
- W3087754470 cites W2911351489 @default.
- W3087754470 cites W2937330368 @default.
- W3087754470 cites W2951085267 @default.
- W3087754470 cites W269265229 @default.
- W3087754470 doi "https://doi.org/10.1038/s41556-020-00577-7" @default.
- W3087754470 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7610479" @default.
- W3087754470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32958857" @default.
- W3087754470 hasPublicationYear "2020" @default.