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- W3087756885 abstract "Mitochondria entail an incredible dynamism in their morphology, impacting death signalling and selective elimination of the damaged organelles. In turn, by recycling the superfluous or malfunctioning mitochondria, mostly prevalent during aging, mitophagy contributes to maintain a healthy mitochondrial network. Mitofusins locate at the outer mitochondrial membrane and control the plastic behaviour of mitochondria, by mediating fusion events. Besides deciding on mitochondrial interconnectivity, mitofusin 2 regulates physical contacts between mitochondria and the endoplasmic reticulum, but also serves as a decisive docking platform for mitophagy and apoptosis effectors. Thus, mitofusins integrate multiple bidirectional inputs from and into mitochondria and ensure proper energetic and metabolic cellular performance. Here, we review the role of mitofusins and mitophagy at the cross-road between life and apoptotic death decisions. Furthermore, we highlight the impact of this interplay on disease, focusing on how mitofusin 2 and mitophagy affect non-alcoholic fatty liver disease." @default.
- W3087756885 created "2020-09-25" @default.
- W3087756885 creator A5019988163 @default.
- W3087756885 creator A5077039103 @default.
- W3087756885 date "2020-09-22" @default.
- W3087756885 modified "2023-10-16" @default.
- W3087756885 title "Role of Mitofusins and Mitophagy in Life or Death Decisions" @default.
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