FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087776181> ?p ?o ?g. }

• W3087776181 abstract "Since its discovery 30 years ago, α-synuclein (α-syn) has been one of the most studied proteins in the field of neuroscience. Dozens of groups worldwide have tried to reveal not only its role in the CNS but also in other organs. α-syn has been linked to several processes essential in brain homeostasis such as neurotransmitter release, synaptic function, and plasticity. However, despite the efforts made in this direction, the main function of α-syn is still unknown. Moreover, α-syn became a protein of interest for neurologists and neuroscientists when mutations in its gene were found associated with Parkinson's disease (PD) and even more when α-syn protein deposits were observed in the brain of PD, dementia with Lewy bodies (DLB), and multiple system atrophy (MSA) patients. At present, the abnormal accumulation of α-syn constitutes one of the pathological hallmarks of these disorders, also referred to as α-synucleinopathies, and it is used for post-mortem diagnostic criteria. Whether α-syn aggregation is cause or consequence of the pathogenic events underlying α-synucleinopathies remains unclear and under discussion. Recently, different in vitro and in vivo studies have shown the ability of pathogenic α-syn to spread between cells, not only within the CNS but also from peripheral locations such as the gut, salivary glands, and through the olfactory network into the CNS, inducing abnormal misfolding of endogenous α-syn and leading to neurodegeneration and motor and cognitive impairment in animal models. Thus, it has been suggested that α-syn should be considered a prion protein. Here we present an update of what we know about α-syn function, aggregation and spreading, and its role in neurodegeneration. We also discuss the rationale and findings supporting the hypothetical prion nature of α-syn, its weaknesses, and future perspectives for research and the development of disease-modifying therapies." @default.
• W3087776181 created "2020-10-01" @default.
• W3087776181 creator A5061678972 @default.
• W3087776181 creator A5087478041 @default.
• W3087776181 date "2020-09-21" @default.
• W3087776181 modified "2023-10-18" @default.
• W3087776181 title "From Synaptic Protein to Prion: The Long and Controversial Journey of α-Synuclein" @default.
• W3087776181 cites W1479935944 @default.
• W3087776181 cites W1505478984 @default.
• W3087776181 cites W1527671059 @default.
• W3087776181 cites W1531667149 @default.
• W3087776181 cites W1535963221 @default.
• W3087776181 cites W1550083773 @default.
• W3087776181 cites W1564387586 @default.
• W3087776181 cites W1637321639 @default.
• W3087776181 cites W1675275370 @default.
• W3087776181 cites W1744659906 @default.
• W3087776181 cites W1786270771 @default.
• W3087776181 cites W1822935226 @default.
• W3087776181 cites W1844422703 @default.
• W3087776181 cites W1853679464 @default.
• W3087776181 cites W1943919857 @default.
• W3087776181 cites W1965095016 @default.
• W3087776181 cites W1965624208 @default.
• W3087776181 cites W1965888147 @default.
• W3087776181 cites W1967640115 @default.
• W3087776181 cites W1967659552 @default.
• W3087776181 cites W1968251608 @default.
• W3087776181 cites W1968957266 @default.
• W3087776181 cites W1969541118 @default.
• W3087776181 cites W1971116939 @default.
• W3087776181 cites W1972601084 @default.
• W3087776181 cites W1972939055 @default.
• W3087776181 cites W1973166472 @default.
• W3087776181 cites W1974433124 @default.
• W3087776181 cites W1974924674 @default.
• W3087776181 cites W1977267085 @default.
• W3087776181 cites W1977576077 @default.
• W3087776181 cites W1977977555 @default.
• W3087776181 cites W1979323586 @default.
• W3087776181 cites W1979591162 @default.
• W3087776181 cites W1979933659 @default.
• W3087776181 cites W1984766678 @default.
• W3087776181 cites W1987744512 @default.
• W3087776181 cites W1989111476 @default.
• W3087776181 cites W1990195639 @default.
• W3087776181 cites W1990473626 @default.
• W3087776181 cites W1992471237 @default.
• W3087776181 cites W1995281235 @default.
• W3087776181 cites W1997604339 @default.
• W3087776181 cites W1999385317 @default.
• W3087776181 cites W1999893655 @default.
• W3087776181 cites W2001176185 @default.
• W3087776181 cites W2008748100 @default.
• W3087776181 cites W2010155317 @default.
• W3087776181 cites W2011332000 @default.
• W3087776181 cites W2011476386 @default.
• W3087776181 cites W2013679718 @default.
• W3087776181 cites W2014413787 @default.
• W3087776181 cites W2017841165 @default.
• W3087776181 cites W2018112212 @default.
• W3087776181 cites W2019863741 @default.
• W3087776181 cites W2024182439 @default.
• W3087776181 cites W2025153638 @default.
• W3087776181 cites W2026717532 @default.
• W3087776181 cites W2028803408 @default.
• W3087776181 cites W2029000167 @default.
• W3087776181 cites W2029241688 @default.
• W3087776181 cites W2035787181 @default.
• W3087776181 cites W2040006951 @default.
• W3087776181 cites W2041134571 @default.
• W3087776181 cites W2042853840 @default.
• W3087776181 cites W2044407202 @default.
• W3087776181 cites W2044908785 @default.
• W3087776181 cites W2046957687 @default.
• W3087776181 cites W2049612563 @default.
• W3087776181 cites W2050235993 @default.
• W3087776181 cites W2050375429 @default.
• W3087776181 cites W2050647292 @default.
• W3087776181 cites W2050786534 @default.
• W3087776181 cites W2052011437 @default.
• W3087776181 cites W2052029809 @default.
• W3087776181 cites W2052222339 @default.
• W3087776181 cites W2055437008 @default.
• W3087776181 cites W2057720588 @default.
• W3087776181 cites W2058631833 @default.
• W3087776181 cites W2061471792 @default.
• W3087776181 cites W2061995199 @default.
• W3087776181 cites W2064963539 @default.
• W3087776181 cites W2066594212 @default.
• W3087776181 cites W2067214698 @default.
• W3087776181 cites W2072427499 @default.
• W3087776181 cites W2073449985 @default.
• W3087776181 cites W2075225622 @default.
• W3087776181 cites W2075793841 @default.
• W3087776181 cites W2076042026 @default.
• W3087776181 cites W2076204506 @default.
• W3087776181 cites W2077044335 @default.
• W3087776181 cites W2077881833 @default.
• W3087776181 cites W2079286281 @default.

• next