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• W308778881 abstract "Research Article1 January 1990free access Induction of a variety of tumors by c-erbB2 and clonal nature of lymphomas even with the mutated gene (Val659----Glu659). Y. Suda Y. Suda Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author S. Aizawa S. Aizawa Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author Y. Furuta Y. Furuta Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author T. Yagi T. Yagi Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author Y. Ikawa Y. Ikawa Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author K. Saitoh K. Saitoh Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author Y. Yamada Y. Yamada Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author K. Toyoshima K. Toyoshima Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author T. Yamamoto T. Yamamoto Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author Y. Suda Y. Suda Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author S. Aizawa S. Aizawa Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author Y. Furuta Y. Furuta Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author T. Yagi T. Yagi Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author Y. Ikawa Y. Ikawa Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author K. Saitoh K. Saitoh Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author Y. Yamada Y. Yamada Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author K. Toyoshima K. Toyoshima Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author T. Yamamoto T. Yamamoto Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author Author Information Y. Suda1, S. Aizawa1, Y. Furuta1, T. Yagi1, Y. Ikawa1, K. Saitoh1, Y. Yamada1, K. Toyoshima1 and T. Yamamoto1 1Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. The EMBO Journal (1990)9:181-190https://doi.org/10.1002/j.1460-2075.1990.tb08094.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The c-erbB2 gene is expressed uniquely in fetal epithelium in vivo and has been suggested to contribute to the development and/or progression of adenocarcinomas in man. In order to assess the oncogenicity of the c-erbB2 gene in vivo, normal c-erbB2 and mutant c-erbB2 encoding glutamic acid instead of valine at position 659 within the transmembrane domain were introduced into mice under the transcriptional regulatory unit of mouse mammary tumor virus long terminal repeat (MMTV-LTR) or immunoglobulin enhancer--SV40 early gene promoter (Ig/Tp). In transgenic mice with normal c-erbB2 under MMTV-LTR, not only adenocarcinomas but also a variety of tumors including B lymphomas were induced at relatively late onset. Induction of pre-B cell lymphomas with normal c-erbB2 was also observed using the Ig/Tp regulatory unit within 6-10 months in some members of one transgenic family among seven lines established. In contrast, with the mutant c-erbB2 under the Ig/Tp regulatory unit, the lymphoma was induced neonatally in all members of four transgenic families among ten lines obtained. However, the immunoglobulin heavy chain gene rearrangement pattern indicated that even with the mutant c-erbB2 the induced lymphomas were clonal. Previous ArticleNext Article Volume 9Issue 11 January 1990In this issue RelatedDetailsLoading ..." @default.
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• W308778881 title "Induction of a variety of tumors by c-erbB2 and clonal nature of lymphomas even with the mutated gene (Val659----Glu659)." @default.
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• W308778881 cites W158850611 @default.
• W308778881 cites W1589525182 @default.
• W308778881 cites W1598175600 @default.
• W308778881 cites W1713048017 @default.
• W308778881 cites W1794613013 @default.
• W308778881 cites W1807228574 @default.
• W308778881 cites W1830988894 @default.
• W308778881 cites W1957044910 @default.
• W308778881 cites W1965372133 @default.
• W308778881 cites W1966683022 @default.
• W308778881 cites W1966823692 @default.
• W308778881 cites W1968075576 @default.
• W308778881 cites W1973033337 @default.
• W308778881 cites W1978580469 @default.
• W308778881 cites W1987905586 @default.
• W308778881 cites W1989193912 @default.
• W308778881 cites W1990367849 @default.
• W308778881 cites W2001627828 @default.
• W308778881 cites W2007256480 @default.
• W308778881 cites W2007647936 @default.
• W308778881 cites W2010527163 @default.
• W308778881 cites W2015394676 @default.
• W308778881 cites W2028387622 @default.
• W308778881 cites W2033618020 @default.
• W308778881 cites W2034442000 @default.
• W308778881 cites W2037722366 @default.
• W308778881 cites W2041354540 @default.
• W308778881 cites W2043711125 @default.
• W308778881 cites W2045220494 @default.
• W308778881 cites W2046439112 @default.
• W308778881 cites W2049214213 @default.
• W308778881 cites W2060333964 @default.
• W308778881 cites W2062059447 @default.
• W308778881 cites W2063450941 @default.
• W308778881 cites W2068901208 @default.
• W308778881 cites W2072140252 @default.
• W308778881 cites W2074610333 @default.
• W308778881 cites W2076892293 @default.
• W308778881 cites W2077077811 @default.
• W308778881 cites W2079561662 @default.
• W308778881 cites W2079816467 @default.
• W308778881 cites W2089723533 @default.
• W308778881 cites W2092229345 @default.
• W308778881 cites W2094929090 @default.
• W308778881 cites W2097563956 @default.
• W308778881 cites W2117237148 @default.
• W308778881 cites W2118929543 @default.
• W308778881 cites W2119244587 @default.
• W308778881 cites W2141393790 @default.
• W308778881 cites W2159363679 @default.
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• W308778881 cites W2418347202 @default.
• W308778881 cites W2431756740 @default.
• W308778881 cites W2440561310 @default.
• W308778881 cites W2443929111 @default.
• W308778881 cites W53637493 @default.
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• W308778881 doi "https://doi.org/10.1002/j.1460-2075.1990.tb08094.x" @default.
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